Q80X60
Gene name |
Efcab3 |
Protein name |
EF-hand calcium-binding domain-containing protein 3 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70894 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80X60
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80X60-F1 | Predicted | AlphaFoldDB |
17 variants for Q80X60
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs223223299 | 27 | L>F | No | EVA | |
| rs256018218 | 27 | L>S | No | EVA | |
| rs3389209751 | 108 | N>D | No | EVA | |
| rs3389179330 | 166 | R>G | No | EVA | |
| rs3389220278 | 171 | H>Y | No | EVA | |
| rs227203999 | 175 | M>L | No | EVA | |
| rs27005391 | 177 | S>N | No | EVA | |
| rs3389224477 | 252 | F>C | No | EVA | |
| rs3389224457 | 256 | Q>H | No | EVA | |
| rs3389183602 | 283 | Q>H | No | EVA | |
| rs227713257 | 291 | K>R | No | EVA | |
| rs3389179246 | 310 | K>R | No | EVA | |
| rs3389196661 | 374 | W>* | No | EVA | |
| rs3389210157 | 381 | E>D | No | EVA | |
| rs3402069940 | 395 | M>I | No | EVA | |
| rs3402719800 | 395 | M>L | No | EVA | |
| rs3389207728 | 415 | D>E | No | EVA |
No associated diseases with Q80X60
6 regional properties for Q80X60
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 53 - 304 | IPR000719 |
| domain | Kinase associated domain 1 (KA1) | 739 - 788 | IPR001772 |
| active_site | Serine/threonine-protein kinase, active site | 171 - 183 | IPR008271 |
| domain | Ubiquitin-associated domain | 323 - 362 | IPR015940 |
| binding_site | Protein kinase, ATP binding site | 59 - 82 | IPR017441 |
| domain | Serine/threonine-protein kinase MARK 1-4, catalytic domain | 52 - 304 | IPR049508 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6P1E8 | Efcab6 | EF-hand calcium-binding domain-containing protein 6 | Mus musculus (Mouse) | PR |
| Q66HC0 | Efcab3 | EF-hand calcium-binding domain-containing protein 3 | Rattus norvegicus (Rat) | PR |
| Q0JC44 | CML22 | Probable calcium-binding protein CML22 | Oryza sativa subsp japonica (Rice) | PR |
| Q9FYK2 | CML25 | Probable calcium-binding protein CML25 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRN6 | CML22 | Probable calcium-binding protein CML22 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVSEIKATM | KLKPLKAPVF | HKRDKDLRGS | FSDHLKHKES | KLSPAQLEAF | RNAYNFFTKD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RTGCIDSHGL | ISTIAKLGMN | LNTYDIYNEL | KCADLDRDGK | INFSDFINVL | TDKKLFLKAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPEKKICLDL | ANNPGILLFE | ILSKFVETSS | LHRKDIIELV | SYFRKRFQES | HSEIMWSSYG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RRGLKSEICS | PPRSSTAAFA | NSARISIMKE | RDLYKFLEAL | KRCNLRTDSP | YSKIPVFPLF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PDVDGTVMGK | PFKDTQKIEM | LRRKEPLTFF | EDYFFNKRDW | KTQAMNVKPL | KSASGYSDDI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAIDHLFKKK | QHWTVTDAAA | IKQHVKKATE | SYNLGIALDH | RKEMLNLWKK | IRGDLVGIES |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NNESFYNTFS | TYTWSWNVCQ | ELLSAKDLRL | HDASMNKSSP | SNSGLSSPSD | FSESDPETGR |
| 430 | |||||
| KRKRKSSRGF | RQ |