Q6P1E8

PR
Gene name
Efcab6 (Djbp, Kiaa1672)
Protein name
EF-hand calcium-binding domain-containing protein 6
Names
DJ-1-binding protein, DJBP
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:77627
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1260-1355 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for Q6P1E8

Entry ID Method Resolution Chain Position Source
8I7O EM 450 A Q1/Q2 1-1516 PDB
8I7R EM 650 A Q1/Q2/Q3 1-1516 PDB
8IYJ EM 350 A i2/i3/i4 1-1516 PDB
8TO0 EM 770 A Ez 1-1516 PDB
AF-Q6P1E8-F1 Predicted AlphaFoldDB

96 variants for Q6P1E8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs263171788 8 L>P No EVA
rs214116925 31 S>A No EVA
rs250786682 41 S>P No EVA
rs3389379632 60 R>S No EVA
rs232589423 75 A>T No EVA
rs248683068 91 A>S No EVA
rs3389330687 113 N>I No EVA
rs31736732 115 M>T No EVA
rs3389393781 136 Q>H No EVA
rs265027590 165 I>T No EVA
rs259212768 184 R>G No EVA
rs31737467 186 V>L No EVA
rs229668983 197 R>Q No EVA
rs3389387760 204 K>* No EVA
rs3406237360 228 T>P No EVA
rs3389375337 246 N>I No EVA
rs249839079 247 I>L No EVA
rs3389349034 248 D>N No EVA
rs215450906 256 N>I No EVA
rs31734013 293 L>P No EVA
rs3389359848 323 Y>* No EVA
rs31738570 362 F>L No EVA
rs3389330734 372 K>* No EVA
rs3389387713 383 L>P No EVA
rs3389372946 390 Q>R No EVA
rs3389372977 402 K>Q No EVA
rs3389359831 423 K>R No EVA
rs3389381844 433 K>N No EVA
rs3389369114 465 D>N No EVA
rs3389359817 496 T>I No EVA
rs3389330682 543 R>S No EVA
rs3389371864 553 F>I No EVA
rs3389371868 596 G>S No EVA
rs3389387711 597 I>M No EVA
rs231342178 601 T>I No EVA
rs265620645 603 P>L No EVA
rs247173540 607 P>L No EVA
rs222422144 617 I>T No EVA
rs253800643 624 D>G No EVA
rs260597553 629 P>S No EVA
rs242103681 632 E>D No EVA
rs3389359880 634 T>N No EVA
rs223535677 637 I>L No EVA
rs31737196 648 G>S No EVA
rs238244436 658 P>S No EVA
rs3389381872 696 Y>N No EVA
rs214494304 697 A>S No EVA
rs3389381902 712 S>N No EVA
rs221186929 726 S>R No EVA
rs253901214 741 T>M No EVA
rs242405118 742 N>S No EVA
rs258758502 788 F>L No EVA
rs3389342121 803 E>D No EVA
rs3389375288 850 A>G No EVA
rs3389372969 851 D>G No EVA
rs3389387766 855 A>V No EVA
rs3389297661 874 L>M No EVA
rs215056133 932 H>Q No EVA
rs3389297673 943 H>P No EVA
rs3389381740 948 E>G No EVA
rs3389379674 976 R>K No EVA
rs3389372983 1048 S>N No EVA
rs31735605 1054 R>H No EVA
rs218467944 1054 R>S No EVA
rs232036884 1071 V>L No EVA
rs216001749 1093 E>K No EVA
rs1132934753 1096 S>F No EVA
rs1132437054 1098 L>M No EVA
rs1135092143 1099 D>E No EVA
rs229244810 1101 E>V No EVA
rs3389371846 1109 M>V No EVA
rs215723472 1161 D>E No EVA
rs31730165 1161 D>N No EVA
rs3389393722 1170 P>T No EVA
rs254126348 1173 M>T No EVA
rs31730164 1181 R>K No EVA
rs3389378557 1196 H>Y No EVA
rs230184911 1210 S>N No EVA
rs3389375327 1213 V>F No EVA
rs3389297676 1250 K>T No EVA
rs233629151 1278 M>I No EVA
rs3389378555 1282 G>E No EVA
rs3389379649 1287 E>D No EVA
rs3389378585 1317 V>E No EVA
rs237932408 1352 T>M No EVA
rs3389372941 1413 S>Y No EVA
rs247449125 1419 R>K No EVA
rs3389371830 1428 E>D No EVA
rs3389393793 1446 K>M No EVA
rs238682504 1463 K>E No EVA
rs3389393726 1467 G>* No EVA
rs3389387802 1484 N>K No EVA
rs3389369111 1486 S>* No EVA
rs3389387758 1497 Y>* No EVA
rs3389369092 1509 D>E No EVA
rs3389372949 1515 L>R No EVA

No associated diseases with Q6P1E8

3 regional properties for Q6P1E8

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 258 IPR000719
active_site Serine/threonine-protein kinase, active site 125 - 137 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytoskeleton, cilium axoneme
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q80X60 Efcab3 EF-hand calcium-binding domain-containing protein 3 Mus musculus (Mouse) PR
Q66HC0 Efcab3 EF-hand calcium-binding domain-containing protein 3 Rattus norvegicus (Rat) PR
Q0JC44 CML22 Probable calcium-binding protein CML22 Oryza sativa subsp japonica (Rice) PR
Q9FYK2 CML25 Probable calcium-binding protein CML25 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRN6 CML22 Probable calcium-binding protein CML22 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKRNGTRLNF AKANSTKSGS TRARDLMNKM SIIPEWHSLY SNTRKLPCSR PHSSPCKMQR
70 80 90 100 110 120
TIFQDLCRPS SSTTAIANPV LSYLDIERIL AQKISSRRDD IKKVFQILDR NHNQMVTKGD
130 140 150 160 170 180
LKRVITAFLI PLTKDQFQDL LAQIPISSLG NVPYLEFLSR FGGGIDININ GIKRVNENEV
190 200 210 220 230 240
DNRRTVKEVQ LTEKIFRNMR SIRKVFQVMD VNNTGLVQPQ ELRRVLETFC LRMQDGDYEK
250 260 270 280 290 300
FLEQYNIDKT TAVDYNAFLK NLSVKNDASF KYLLSNAAEL SRETQQGKNG KRLLDTGSSE
310 320 330 340 350 360
DVWKNYSLDD LEKTFCQEFS KSYEKIEKAL SAGDPSKGGY ISLNYLKVVL DTFIYRLPRR
370 380 390 400 410 420
IFIQLIRRFG LKTSTKINWK QFLTAIYERQ KLEVSKTLPL KKRSSTEARN RSRKENIIKK
430 440 450 460 470 480
LFKYSEDRYT ALKKTLLIIS STPSGHITWE ELRHILNCMV AKLNDSEFSE LKQTFDPEGT
490 500 510 520 530 540
GAVRVNSLLD VLDDSTKVRK MSPSTDTKTP LPVAWDSVEE LVLDSITRNL QAFYSMLQSY
550 560 570 580 590 600
DLRDTGTIGK NNFRKVMRVF CPYLSNEHLV RFSSKFQEAG SGRILYKKFL LSIGVGIPPP
610 620 630 640 650 660
TPPLSSPKVQ LSDQFQIEEP GQQDERTQPS GEKTSEINNM TKEEVIDGLK HRIQQKDPVF
670 680 690 700 710 720
RKQFLSISKE PDVKINQEEF RKVLERSGMP MNDCQYAMLA SKLGFKNEEG MSYQDFTMGF
730 740 750 760 770 780
EDCMLSGLET VPLQSRTASR TNMDEHFISA EECLRIFPKK LKESFRDVYS AFFRIDLDRD
790 800 810 820 830 840
GIISMHDFHR LLQYLQLNMV DLEFERFLSL LGLRLSVTLN FREFQNLCEK RPWKSDEAPQ
850 860 870 880 890 900
RLIRCKQKVA DSELACEQAH QYLIMKAKTR WADLSKNFIE TDNEGNGILR RRDIKNSLYG
910 920 930 940 950 960
FDIPLTPREF EKLWQNYDTE GRGYITYQEF LHRLGIRYSP KVHRPYKEDY FNFLGHFTKP
970 980 990 1000 1010 1020
KQVQEEIQEL QQISEREKLM NHYEEISKAF NAMEKSKPVA LCRVQKVLQE CGCPLKEEEL
1030 1040 1050 1060 1070 1080
ISLLKSLDVS VHNNHIDPVE FLRALEISWA SKARPKEKEE SSPPPISFSK VTPDEVIKTM
1090 1100 1110 1120 1130 1140
QEVVESSQPA LVEAFSALDK EDTGFVKAME FGDVLRSVCQ KLTDNQYHYF LRRLRLHLTP
1150 1160 1170 1180 1190 1200
NIHWKYFLEN FSTFQDETAD DWAENMPKAP PPMSPKETAH RDIVARVQKA VASHYHTIVQ
1210 1220 1230 1240 1250 1260
EFENFDTLKS NTVSRDEFRS ICTRHIQILT DEQFDRLWSE LPVNAKGRLK YQDFLSKLSI
1270 1280 1290 1300 1310 1320
ERVPSPPMAA GDSGESTMAQ RGSSAPEFSQ GTRSNLYSPP RDSRVGLKSR SHPCTPVGTP
1330 1340 1350 1360 1370 1380
PLQNCEPIES RLRKQIQGCW RELLRECKEK DTDKQGTISA AEFLALVEKF KLDISREESQ
1390 1400 1410 1420 1430 1440
QLIVKYDLKN NGKFAYCDFI QSCVLLLKAK ETSLMRRMRI QNADKMKEAG METPSFYSAL
1450 1460 1470 1480 1490 1500
LRIQPKIVHC WRPMRRSFKT YDKNGTGLLS VADFRKVLRQ YSINLSEEEF FHVLEYYDKS
1510
LSSKISYNDF LRAFLQ