Q80UU9

PR
Gene name
Pgrmc2
Protein name
Membrane-associated progesterone receptor component 2
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:70804
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

50-125 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q80UU9

Entry ID Method Resolution Chain Position Source
AF-Q80UU9-F1 Predicted AlphaFoldDB

7 variants for Q80UU9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3392916088 18 E>V No EVA
rs235774741 22 D>N No EVA
rs3392881269 165 D>E No EVA
rs3388629619 170 N>D No EVA
rs3388625760 207 E>K No EVA
rs3388631838 210 T>I No EVA
rs13466299 211 K>R No EVA

No associated diseases with Q80UU9

1 regional properties for Q80UU9

Type Name Position InterPro Accession
domain Cytochrome b5-like heme/steroid binding domain 97 - 195 IPR001199

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
  • Nucleus envelope
  • Endoplasmic reticulum
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

3 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
heme transmembrane transporter activity Enables the transfer of heme from one side of a membrane to the other.
steroid binding Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.

2 GO annotations of biological process

Name Definition
adipose tissue development The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.
heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5XIU9 Pgrmc2 Membrane-associated progesterone receptor component 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAAGDGDVKL STLGSGGESG GDGSPGGAGA TAARSSWVAA LLATGGEMLL NVALVALVLL
70 80 90 100 110 120
GAYRLWVRWG RRGLCSGPGA GEESPAATLP RMKKRDFSLE QLRQYDGART PRILLAVNGK
130 140 150 160 170 180
VFDVTKGSKF YGPAGPYGIF AGRDASRGLA TFCLDKDALR DEYDDLSDLN AVQMESVREW
190 200 210
EMQFKEKYDY VGRLLKPGEE PSEYTDEEDT KDHSKQD