Q5XIU9
Gene name |
Pgrmc2 |
Protein name |
Membrane-associated progesterone receptor component 2 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:361940 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5XIU9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5XIU9-F1 | Predicted | AlphaFoldDB |
No variants for Q5XIU9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5XIU9 | |||||
No associated diseases with Q5XIU9
1 regional properties for Q5XIU9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cytochrome b5-like heme/steroid binding domain | 97 - 195 | IPR001199 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endomembrane system | A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| heme transmembrane transporter activity | Enables the transfer of heme from one side of a membrane to the other. |
| steroid binding | Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| adipose tissue development | The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. |
| heme transport | The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q80UU9 | Pgrmc2 | Membrane-associated progesterone receptor component 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAGDGDVKL | STLGSGGERG | GDGSPGGAGA | TAARSSWVAA | LLATGGEMLL | NVALVALVLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GAYRLWVRWG | RRGLCSGPGA | GEESPAATLP | RMKKRDFSLE | QLRQYDGART | PRILLAVNGK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VFDVTKGSKF | YGPAGPYGIF | AGRDASRGLA | TFCLDKDALR | DEYDDLSDLN | AVQMESVREW |
| 190 | 200 | 210 | |||
| EMQFKEKYDY | VGRLLKPGEE | PSEYTDEEDT | KDHSKQD |