Q80TA9
PR
Gene name |
Epg5 (Kiaa1632) |
Protein name |
Ectopic P granules protein 5 homolog |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:100502841 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q80TA9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q80TA9-F1 | Predicted | AlphaFoldDB |
110 variants for Q80TA9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs29873372 | 34 | G>A | No | EVA | |
| rs29873372 | 34 | G>V | No | EVA | |
| rs215221775 | 36 | L>V | No | EVA | |
| rs233678296 | 41 | R>S | No | EVA | |
| rs252750129 | 53 | K>I | No | EVA | |
| rs227411820 | 59 | S>A | No | EVA | |
| rs234866559 | 61 | A>S | No | EVA | |
| rs260761032 | 62 | D>A | No | EVA | |
| rs221320614 | 94 | V>I | No | EVA | |
| rs238793256 | 109 | G>S | No | EVA | |
| rs258346648 | 112 | D>N | No | EVA | |
| rs3408416785 | 172 | H>R | No | EVA | |
| rs248977213 | 206 | P>L | No | EVA | |
| rs46425996 | 248 | T>A | No | EVA | |
| rs1133602892 | 275 | D>N | No | EVA | |
| rs3408984587 | 314 | H>Q | No | EVA | |
| rs260144486 | 341 | Y>H | No | EVA | |
| rs864276321 | 471 | H>Y | No | EVA | |
| rs37260038 | 478 | V>I | No | EVA | |
| rs3406873605 | 540 | P>* | No | EVA | |
| rs36284428 | 584 | Q>K | No | EVA | |
| rs218170723 | 660 | S>N | No | EVA | |
| rs37478539 | 701 | F>L | No | EVA | |
| rs37845802 | 783 | T>N | No | EVA | |
| rs3408622992 | 838 | Q>K | No | EVA | |
| rs238221005 | 877 | N>Y | No | EVA | |
| rs3389511921 | 977 | F>V | No | EVA | |
| rs3389520552 | 987 | F>Y | No | EVA | |
| rs3389515513 | 1015 | C>W | No | EVA | |
| rs3389523491 | 1022 | T>I | No | EVA | |
| rs3389512757 | 1050 | A>T | No | EVA | |
| rs3389510613 | 1086 | D>E | No | EVA | |
| rs3389510680 | 1126 | C>Y | No | EVA | |
| rs3389520551 | 1138 | A>T | No | EVA | |
| rs3389520527 | 1166 | L>F | No | EVA | |
| rs3389490539 | 1171 | F>S | No | EVA | |
| rs3389510655 | 1202 | S>C | No | EVA | |
| rs3389512829 | 1262 | Q>R | No | EVA | |
| rs3389523475 | 1271 | L>R | No | EVA | |
| rs3408701848 | 1272 | K>Q | No | EVA | |
| rs3389504860 | 1276 | V>L | No | EVA | |
| rs3389515489 | 1282 | L>P | No | EVA | |
| rs3389510622 | 1348 | R>C | No | EVA | |
| rs232844317 | 1376 | G>R | No | EVA | |
| rs3389469900 | 1378 | A>S | No | EVA | |
| rs3389419493 | 1384 | L>R | No | EVA | |
| rs3389490616 | 1440 | M>I | No | EVA | |
| rs3389511879 | 1475 | A>V | No | EVA | |
| rs3389460022 | 1485 | A>T | No | EVA | |
| rs3389523538 | 1486 | K>R | No | EVA | |
| rs264785175 | 1519 | A>V | No | EVA | |
| rs3389520497 | 1527 | T>I | No | EVA | |
| rs3389490534 | 1606 | V>I | No | EVA | |
| rs3389523521 | 1615 | K>I | No | EVA | |
| rs36313644 | 1671 | D>N | No | EVA | |
| rs260845908 | 1699 | V>I | No | EVA | |
| rs3389490548 | 1705 | E>* | No | EVA | |
| rs3389419511 | 1732 | A>V | No | EVA | |
| rs3389504037 | 1751 | N>I | No | EVA | |
| rs3389520532 | 1800 | I>N | No | EVA | |
| rs3389477835 | 1804 | F>C | No | EVA | |
| rs3389490562 | 1806 | L>P | No | EVA | |
| rs3389515450 | 1807 | F>I | No | EVA | |
| rs3413128368 | 1824 | S>I | No | EVA | |
| rs3389527226 | 1843 | C>* | No | EVA | |
| rs3389511934 | 1845 | K>T | No | EVA | |
| rs37893178 | 1875 | R>G | No | EVA | |
| rs244484183 | 1878 | L>M | No | EVA | |
| rs3407798911 | 1882 | Q>H | No | EVA | |
| rs38564758 | 1884 | M>T | No | EVA | |
| rs3389490574 | 1913 | W>* | No | EVA | |
| rs3389477848 | 1940 | S>P | No | EVA | |
| rs3408814417 | 1958 | I>N | No | EVA | |
| rs37146659 | 1963 | K>T | No | EVA | |
| rs3407722550 | 1964 | P>T | No | EVA | |
| rs3389510693 | 1977 | Q>* | No | EVA | |
| rs3389515528 | 2007 | S>N | No | EVA | |
| rs3389520490 | 2054 | K>T | No | EVA | |
| rs3389419530 | 2079 | L>M | No | EVA | |
| rs244530598 | 2108 | S>N | No | EVA | |
| rs263115036 | 2130 | P>A | No | EVA | |
| rs3389504046 | 2139 | G>E | No | EVA | |
| rs232068544 | 2167 | P>L | No | EVA | |
| rs37610982 | 2169 | V>I | No | EVA | |
| rs236832873 | 2233 | R>Q | No | EVA | |
| rs38691907 | 2252 | S>N | No | EVA | |
| rs3389477867 | 2261 | S>R | No | EVA | |
| rs3408814435 | 2276 | P>A | No | EVA | |
| rs3408701852 | 2276 | P>R | No | EVA | |
| rs3413106960 | 2289 | I>F | No | EVA | |
| rs3389511890 | 2315 | M>I | No | EVA | |
| rs38181749 | 2318 | I>T | No | EVA | |
| rs3408814373 | 2340 | P>S | No | EVA | |
| rs235914343 | 2341 | V>I | No | EVA | |
| rs262329018 | 2349 | Q>E | No | EVA | |
| rs224427448 | 2352 | A>T | No | EVA | |
| rs585985293 | 2352 | A>V | No | EVA | |
| rs241529584 | 2353 | R>Q | No | EVA | |
| rs260924963 | 2354 | D>E | No | EVA | |
| rs3389506800 | 2384 | N>Y | No | EVA | |
| rs237263300 | 2385 | D>E | No | EVA | |
| rs261960077 | 2394 | G>S | No | EVA | |
| rs3408893347 | 2403 | S>P | No | EVA | |
| rs36851141 | 2436 | V>I | No | EVA | |
| rs3389419460 | 2503 | E>D | No | EVA | |
| rs3389506815 | 2503 | E>Q | No | EVA | |
| rs3389506768 | 2504 | L>S | No | EVA | |
| rs36791004 | 2535 | H>P | No | EVA | |
| rs262103436 | 2536 | A>V | No | EVA | |
| rs3389510659 | 2546 | C>F | No | EVA |
No associated diseases with Q80TA9
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome maturation | Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. |
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| cellular response to dsDNA | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus. |
| endocytic recycling | The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. |
| endosome to lysosome transport | The directed movement of substances from endosomes to lysosomes. |
| nucleotide transport | The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell. |
| toll-like receptor 9 signaling pathway | The series of molecular signals initiated by a ligand binding to toll-like receptor 9. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAEAVKPRRA | KAKASRTKGK | EKKKHEALQT | CDAGPLPETC | REQESPCPAS | ELKGDDLKSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ADPQLHSDVC | GWNESEMFDI | PLTSLTIGDE | GPPVQDTEDL | KERGEVTAGD | GDDEMELKVD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PGDNVIAKGE | PCKNFPEVED | HTLIQCGPPE | STLQPDFPCT | QQAVEGSHAR | EHPTRKQDEA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ALGCSKVFQN | VSLHSSYEAK | EVSQPPRVKK | LYPELPAEIA | EVPALVAVKP | LLRSERLYPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPSQPEVTPF | TKEQLKLLEP | GSWLENVASY | VEEFDNIAHQ | DRHEFYELLL | NYSRCRKQLL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAEAELLTLM | SDCHSAKSRL | WHFKDEQMAV | QGICADQVKV | YGHHHYQRVE | MNENVLGELK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KLFDAKSEHL | HQTLTLHSYT | SVLSRLQVES | YIFTLLNSSA | ALRSLAVYQA | DQVPKLTESI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PSDVCQLKEC | ISVLFMFTRR | VSEDAQFHED | ILLWLQKLVS | VLQRVGCPGD | HFFLLNHVLR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| CPAGIRKWAV | PFIQIKVLNN | PSGVFHFMQS | LALLMSPVKN | RAEFMCHMKP | SEWKPSSSGP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ASGNWTLVDE | AGEEDEDPET | SWILLNEDDL | VTLLSQFPFQ | ELFQHLLGFK | AKGDYLPETT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RPQEMMKIFA | FANSLVELLA | VGLDTFNRAR | YRQFVKRIGY | LIRMTLGYVS | DHWAQYVSHS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TGAGLTPQPY | SMEKLQVEFD | ELFLRAVLHV | LKAKRLGIWL | FMSEMPFGTL | SVQMLWKLLY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LMHQVESGDL | QQLCASLQPA | ECKRRLQDPE | HFASFEKCLS | SINSSEEICL | LTAFAQMARA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RRTNVDEDFI | KIIVLEIYEV | SYVTLSTRET | FSKVGRELLG | AIAAVHPEII | SVLLDRVQET |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IDQVGMVSLY | LFKELPLYLW | RPSAPEIAVI | RDWLLNNNLT | AVKNKLACVI | LEGLNWGFTE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QGTLHLDQAL | HTEVALLVLE | AYQKYLAQKP | YTGLISESMK | QVSYLASIVR | YGETPETSFN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| QWAWNLILRL | KLHKNDFGRQ | NFPVIPFCST | VPDMTESSMF | HPLLKAVKSG | LPIGCYLALA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VTAVGHSLEK | FCAEGIPLLG | VLVQSRHLRA | VVHALDKILP | VFYPYQCYLL | KNEQFLSNLL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LFLQLDSGVP | QGVTQQVTHR | VAQHLTGAVH | GDNVKLLSSM | IQAHICVSTQ | PDGVGPVAVL |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| EFWVQALISQ | HLWYREQPIL | FLMDHLCKTA | FHLMQEDCVQ | KLLYQQHKNA | LGYHCDRSLL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SSLVNWIVAG | NITPSFVEGL | STSTQVWFAW | TVLNMESIFE | EDSQLRRVVE | RELVINAFSP |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| DQALKKAQVQ | LKLPIVPSLQ | RLLIYRWAHQ | ALVTPSDHPL | LPLIWQKFFL | LYLHRPGPQY |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| GLPVDGCIGR | RFFQSPSHVN | LLKDMKRRLT | EVADFHYAAS | KALRVPAEGS | EGTPEGQAGT |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| PGFLTSPELH | RELVRLFNVY | VLWLEDENFQ | KGDTYIPSLP | KHYDVHRLAK | VMQNQQDLWM |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| EYVNMERIQH | EFQETVALWT | QAKLESHAAP | CSSSAQLDFT | DPLLAKARVL | SNLEKHEAPH |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| PPLLLHPVRP | PVPLIPSAAL | LTQKDSTQLM | CTDLNLLQQQ | ARSATLRESQ | QVALDGELLE |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| TMPKQYVNRE | DQATLHLECR | GSSGKKCQGA | AVVTVQFEGM | NKNEAVSQQI | HVLQKEVRQL |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| QAEAAQPPAL | NVVEAAVHAE | NLITALVNTY | KLQPTPGVQK | LGISLFFTVV | DHVSDETQRH |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| PPTRQFFTSC | IEILGQVFVS | GTKSECRKLL | QTILKNRRLC | SLLAPFFTPN | AAPAEFIQLY |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| ERVVTCLRED | NSDVIFMLLT | KFDIQQWLNS | TKPPLSDRTR | LLESIHLALT | AWGLEPEEDI |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| LMPFNLFCKH | WTHLLLYQFP | DQYSDVLRLL | VQSSAEQLLS | PECWKATLRA | LGCYAPSSQQ |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| GAASVESSGL | HSASRVLLSD | KQVMETVQWL | SDFFYKLRLS | KLDFKSFGLF | SKWSPYMADV |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| KTFLGYLVKR | LTDLEIASLS | QDPTASSKEV | LRSLHAQIIQ | LFKPWILVLE | DAESSHQRHY |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| PWLESDTAVA | SSIVQLFSDC | VGSLHTSFKD | RLLPGDEGAL | RLHLLHYCET | CTAPKMPEFI |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| LYAFHSAYQR | LEWKDLHPDQ | RLMEAFFKVE | RGSPKSCFLF | LGSVLCRVNW | VSVLSDAWNP |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| SPLPETQSMA | VCLLFMMVLL | AKEAQLVDEP | DSPLLSLLGQ | TSSLSWHLVD | LVSYQSVLGY |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| FSSHYPPSVV | LANDCSSELI | VKLLKVSAGL | SAHADGRKHV | DIVPKCQAFT | HQMVQFLSAL |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| EQTGKITFPA | LEREISKLLD | DIIIFNPPDM | DSQTRHMALS | SFFVEVLMMM | NNAAVPTAEF |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| LAVSIRTWIG | QRVHGLIVLP | LLTAACQSLA | SVRHMAEITE | ACIMAYFKES | SLDQNLGWGP |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| VLVSLQVPQL | TARDFLEECL | ALGSCLTLYV | YLLQCLNSEQ | TVKNDMKMLL | VVSGWLEQVY |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| PSSAQEEAKL | FLWWHQILQL | SLIQLEQNDS | VLTESVIRIL | LMLQSRQSLM | AEERLSSGIL |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| GAIGLGRRSP | LSNRFRVAAR | SMAAFLLVQV | PAEDQIRLKP | SSELHLAPKA | QQVLTALESM |
| 2530 | 2540 | 2550 | 2560 | 2570 | |
| TLSKQYVEYQ | DQILHALQFI | RHPGHCLQNG | KSFLALLVNR | LYPEVHYLDN | IR |