A5WUT8

PR
Gene name
epg5 (si:dkey-165i4.3)
Protein name
Ectopic P granules protein 5 homolog
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:569543
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-163 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A5WUT8

Entry ID Method Resolution Chain Position Source
AF-A5WUT8-F1 Predicted AlphaFoldDB

No variants for A5WUT8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5WUT8

No associated diseases with A5WUT8

No regional properties for A5WUT8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A5WUT8

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
autophagosome maturation Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
autophagosome-lysosome fusion The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome.
intestinal epithelial cell development The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.
intestinal stem cell homeostasis Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9HCE0 EPG5 Ectopic P granules protein 5 homolog Homo sapiens (Human) PR
Q80TA9 Epg5 Ectopic P granules protein 5 homolog Mus musculus (Mouse) PR
10 20 30 40 50 60
MLHLQVKKER QSESVRQPSG SSKAVNEPEF TDVPLSLPHV PPDLNTAASQ TSLDHHDKAE
70 80 90 100 110 120
NEQQHVLLCE KPEVVQKSTC HEDKEHELPS QDAAPRLDQT SVLAPSSQSD PKPLSAKLEP
130 140 150 160 170 180
FSVPSIYPSI PASLSQPQLS EDSYSISYEL LDGSLMPAAS ERLVAPAVLT LANQESSPPS
190 200 210 220 230 240
LVPVEVVDVE RSRERLYPEL PKTCQSVKPF TSEQLRMWEP GSWLENVELH EAEFQNLAHQ
250 260 270 280 290 300
EGHELYELLL SYWRCRKQLT QAQTELQAAN SDCKNVQNRL WSFKDERLSL QGICADQNKV
310 320 330 340 350 360
YGYHCYQQVT LNEAALAELK HLFSAKAEIL HQTVALHSYT SILSRLQVES YLYRLLSSNP
370 380 390 400 410 420
TTKSVAVQDT SAGNPKSQPS SLQPLKESIS VLFIFTRRVL DDSQFQADIH LWLQRLVSVL
430 440 450 460 470 480
HQVGSTGDHL FILNHLLCCP AGVGKWAVPF LQIKVLDNPS GVYHFMQALA ILMSPARHRP
490 500 510 520 530 540
DFLGHMKPSD ARGNNSLTEP ASGNWTLVDE GGEEDEDPET SWMLLSEDDL VSLFSQFPFD
550 560 570 580 590 600
ELFKHLLGIC SKGDYQPLAT TSQKMMKIFA FASSLVELLA VGLQTYNRAR YRQFVKRIGH
610 620 630 640 650 660
MIRMTLCYVS DHWAQYISLT GVSRTTVQEQ SFSMEKLQVE FDHLFLRAVL HVLKAKRLGI
670 680 690 700 710 720
WLFMSEMPYG TLSSSMLWKI FYIMQCAETD GLEKLSCSLS AEDCIQRLRE SSHQERFQLW
730 740 750 760 770 780
LSEINSSDGI CLLTTFAHMA QPRRTDVDPE FVRNIVLEIY EVSYVSVTTR EIFSKVGREL
790 800 810 820 830 840
LAAIAAAHPH IISVLLERLR ETIERVGMVS LYLFKELPLH LWMPAQEEVG LIRDWLMNFS
850 860 870 880 890 900
LTAVENRLAC IILEGLNWGF QPNGCLILPA PLHSDVALLV IEAYQKYLTD KPYGGILSEG
910 920 930 940 950 960
IKQVSYLANV VRLGQTPESS FNQWAWDIVL RLKLHANERS PQDAWCPLPS SSAPSVPEIT
970 980 990 1000 1010 1020
DSPIMHPVFK AVKAGIPIGC FLAIEMTTIG HSLEKFCSEG ISLLKTLIQS RHLRAAVHIL
1030 1040 1050 1060 1070 1080
ENILPLVYNC QFYLLKNEQF LSCVQLFLQL DSGTQGVTQQ VTQKVAQHLI GPATCENIKL
1090 1100 1110 1120 1130 1140
LNSVIQAHVL ESSRNGRVGA VAVLEFWLQV LTEQSLWYRD RAVLFLLDHM CRSAFLHQQE
1150 1160 1170 1180 1190 1200
ECLQKILYQQ HKSALGYHGD KGLLSSIMGW IVAGNVTPSF IEGSSLTGEV WFAWMILNME
1210 1220 1230 1240 1250 1260
TMFEEDSQLR RCVEHELLSN PACTPDQALK KAQVRLKLQV VPSLQRLMIY RWAQQALATP
1270 1280 1290 1300 1310 1320
ADHPILPLVW QKFFQLYLRQ PGPEFGLEVK GCIGRRYFHS AAHLSLLKSL RQRLVEVSDF
1330 1340 1350 1360 1370 1380
HHAASKALKV PCASGDSGDG LLTPGTPITQ YMTSPDLHTE IVRLFTVFAL WLDDENLQKQ
1390 1400 1410 1420 1430 1440
EIYLPSLPKQ YDTHRLAKIM QRQQEVWMEH VDIERVQHEL QEVLDLWSKV KSEPAVSQNS
1450 1460 1470 1480 1490 1500
SSSIFTDFIN PLAARERILT HLRKHDAPQG SLLPVPMKAP VPDIPTASLT DEKISTTLIQ
1510 1520 1530 1540 1550 1560
EDLTKLQHQA KLATVRETQQ VALDNELLEV LPQLYINRED QLSMQLECRG KSGQPCQGPA
1570 1580 1590 1600 1610 1620
NITVKYSSMH KLEPVQNQIQ SLKSDIKQLQ ADGIKAPPQS LAEAAVHTEN FITALVNVFK
1630 1640 1650 1660 1670 1680
QNPSPGVLKV GITAFYQIVS FVCEDTQRHP PTRQFFTSCI EILGQVFIRD VQSECKHMLK
1690 1700 1710 1720 1730 1740
TILLNRRLCN LLSPYFTPNA SPSELVSLYE EVVNTLHIDS GDVIFMLLTK FDLFQWLSTT
1750 1760 1770 1780 1790 1800
QPPFSERSRL MTVIHQALCT CGLEPEPEVL MPFNIFCKHW TELLLYQFPD HYSDFLRLLM
1810 1820 1830 1840 1850 1860
QSSSDQLLSP DCWRTSLKAL GCSPQTKNKT NKSRSMLLSP QQVDETIEWL SKYFLKLRLS
1870 1880 1890 1900 1910 1920
NGDFRSFGLL SKWGPYIEEV KVFWEDLITY VIDLELNHCG KEPVGSPRLL KALENLHRKM
1930 1940 1950 1960 1970 1980
AKLFEPWILV LDTDNTSHPR CSPWLESDAA VAASLVGLYT RLTETLHEKF KDRLLPGQRG
1990 2000 2010 2020 2030 2040
ALWLHLMFYC ETCTSPKMPE YLLYTYHTEY SRLPWKDLHP DQTLMNQFFN VERGSPKSCF
2050 2060 2070 2080 2090 2100
VFMGELLCEV NWVSVLSDSL SPQLNPSTHT MVVSVLHLMV FLAKEDLSKP ESSVLSLLDQ
2110 2120 2130 2140 2150 2160
SASLPWNLVD FSSYQNVTRY VSTHYPASLV LSHDTSSQQV VRLLRMAAGF EPTTQVLHHK
2170 2180 2190 2200 2210 2220
DMTLKCQAFL HLMVQFLTSL DQNGNISLAS LETEMEKLLE NIVIFNPPET DLQQRHMATC
2230 2240 2250 2260 2270 2280
SLFAEMLTLL NEAGISTAEG LGTKLHCWVE KRARGPLLLP LLTAACRCLA SVRHMTRTTE
2290 2300 2310 2320 2330 2340
ACILSYFTDG CVDQYSGWGP ILVSLQVPEL TVEDFIQESL SLGSFLTLYV YILQRLNLEQ
2350 2360 2370 2380 2390 2400
TLLNEKKTLM LLNTWISQVF PSGPADEAKL FLWWHKFLEL LQIQVDQEDA CSLDTLILTL
2410 2420 2430 2440 2450 2460
MAFQNRLVQL GEERLNSGIL GAIGLGRKSP LSNRFRVVAR SMSAFLLVQV PSENQLRLHP
2470 2480 2490 2500 2510 2520
GTELQLSAKA QQALSALEAM ASNKQYSELH VSVNQACQFI KYPNHCLRDA NTLLTLLVNA
2530
LYTDLHYLDI IR