Q7ZVE6

PR
Gene name
poglut2 (kdelc1, si:dkey-22a1.1, zgc:56065)
Protein name
Protein O-glucosyltransferase 2
Names
KDEL motif-containing protein 1, Protein O-xylosyltransferase POGLUT2
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:393905
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7ZVE6

Entry ID Method Resolution Chain Position Source
AF-Q7ZVE6-F1 Predicted AlphaFoldDB

No variants for Q7ZVE6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7ZVE6

No associated diseases with Q7ZVE6

3 regional properties for Q7ZVE6

Type Name Position InterPro Accession
repeat Filamin/ABP280 repeat 27 - 132 IPR001298
domain Glycosyl transferase CAP10 domain 148 - 480 IPR006598
repeat Filamin/ABP280 repeat-like 23 - 125 IPR017868

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum lumen
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum.

5 GO annotations of molecular function

Name Definition
EGF-domain serine glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + -3-O-(beta-D-glucosyl)-L-serine.
EGF-domain serine xylosyltransferase activity Catalyses the reaction: UDP-alpha-D-xylose + -3-O-(beta-D-xylosyl)-L-serine.
glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.
UDP-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule.
UDP-xylosyltransferase activity Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule.

1 GO annotations of biological process

Name Definition
protein O-linked glycosylation via serine The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9Q1 POGLUT1 Protein O-glucosyltransferase 1 Bos taurus (Bovine) PR
Q8NBL1 POGLUT1 Protein O-glucosyltransferase 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MLRKLLLLLM SCIIFLTRRS KAAAAASASK TLVWGPGLET NAVLPARFFF IQTVDTTGTN
70 80 90 100 110 120
FTTSPGENTF EVKITSPTEP YARIWIQILD RNDGSFLVRY RMYASYTDLH VEVLLKDKLV
130 140 150 160 170 180
GKSPYVLRGA VYHESCDCPE PDGALWEKNM HCPASFSQIE SDLSIFQSVD PDRNAHEIIQ
190 200 210 220 230 240
RFGKSHSLCH YTIKNNQVYI KTHGEHVGFR IFMDAFLLSL TRKVKLPDIE FFVNLGDWPL
250 260 270 280 290 300
EKRRASQNPS PVFSWCGSND TRDIVMPTYD LTESVLETMG RVSLDMMSVQ GHTGPVWEKK
310 320 330 340 350 360
INKGFWRGRD SRKERLELVK LARANTAMLD AALTNFFFFK HDESLYGPLV KHVSFFDFFK
370 380 390 400 410 420
YKYQINVDGT VAAYRLPYLL AGDSVVFKHD SIYYEHFYNE LQPWVHYIPF RSDLSDLLEK
430 440 450 460 470 480
IQWAKDHDEE AKKIALAGQQ FARTHLMGDS VFCYYHKLFQ KYAELQVTKP KVRDGMELVE
490
QPKDDLFPCY CARKKVRDEL