AiPD: Autoinhibited Protein Database

Q7Z6K3

Gene name	PTAR1
Protein name	Protein prenyltransferase alpha subunit repeat-containing protein 1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:375743
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

306-393 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

306-393 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

6 structures for Q7Z6K3

Entry ID	Method	Resolution	Chain	Position	Source
6J6X	X-ray	296 A	A	1-339	PDB
6J74	X-ray	321 A	A	1-327	PDB
6J7F	X-ray	288 A	A	1-327	PDB
6J7X	X-ray	275 A	A	1-327	PDB
6O60	X-ray	250 A	A	1-402	PDB
AF-Q7Z6K3-F1	Predicted				AlphaFoldDB

262 variants for Q7Z6K3

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA373636213 rs749422932	3	E>A		No	ClinGen ExAC gnomAD
CA5075637 rs749422932	3	E>V		No	ClinGen ExAC gnomAD
CA373636207 rs1398642473	4	T>S		No	ClinGen TOPMed
CA373636202 rs1354997966	5	S>G		No	ClinGen gnomAD
CA194027380 rs866087896	6	E>*		No	ClinGen gnomAD
rs868784855 CA194027379	6	E>D		No	ClinGen gnomAD
CA373636195 rs866087896	6	E>K		No	ClinGen gnomAD
CA373636181 rs1334392093	8	V>M		No	ClinGen gnomAD
CA373636171 rs755835716	9	A>E		No	ClinGen ExAC TOPMed gnomAD
COSM1462781 CA5075635 rs755835716 COSM1462782	9	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1160180644 CA373636170	10	V>M		No	ClinGen gnomAD
CA5075633 rs781265092	12	V>A		No	ClinGen ExAC gnomAD
CA373636155 rs781265092	12	V>G		No	ClinGen ExAC gnomAD
rs866761293 CA194027378	13	Q>*		No	ClinGen Ensembl
rs866225196 CA194027377	14	R>L		No	ClinGen Ensembl
TCGA novel	14	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1188752382 CA373636101	21	N>D		No	ClinGen gnomAD
CA373636087 rs1488054084	23	F>L		No	ClinGen gnomAD
rs765935335 CA5075630	24	R>S		No	ClinGen ExAC TOPMed
TCGA novel	25	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1219206150 CA373636063	26	N>S		No	ClinGen gnomAD
CA373636040 rs1447985741	29	I>R		No	ClinGen gnomAD
CA5075609 rs750005566	30	D>E		No	ClinGen ExAC TOPMed gnomAD
CA5075610 rs200966061	30	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	33	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5075608 rs764792126	33	G>V		No	ClinGen ExAC gnomAD
CA373635599 rs1211880571	35	I>M		No	ClinGen gnomAD
CA373635596 rs1348156988	36	P>S		No	ClinGen gnomAD
CA373635591 rs1274137236	37	C>R		No	ClinGen TOPMed
CA373635587 rs1284968239	37	C>Y		No	ClinGen gnomAD
rs753502633 CA5075606	38	P>S		No	ClinGen ExAC gnomAD
CA5075607 rs753502633	38	P>T		No	ClinGen ExAC gnomAD
CA194026355 rs1031411314	41	R>G		No	ClinGen TOPMed
CA373635564 rs1219832202	41	R>K		No	ClinGen TOPMed
CA5075605 rs767821443	43	N>S		No	ClinGen ExAC gnomAD
rs1307664969 CA373635544	44	R>W		No	ClinGen TOPMed gnomAD
CA5075604 rs375276838	45	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA5075601 rs762931672	49	L>V		No	ClinGen ExAC gnomAD
rs1588484459 CA373635506	50	V>A		No	ClinGen Ensembl
rs377658803 CA5075600	52	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5075598 rs748348019	55	G>D		No	ClinGen ExAC TOPMed gnomAD
CA5075597 rs777020228	57	E>K		No	ClinGen ExAC gnomAD
rs1588484403 CA373635416	63	F>Y		No	ClinGen Ensembl
CA5075596 rs768537275	64	L>F		No	ClinGen ExAC gnomAD
rs1411412423 CA373635394	66	P>L		No	ClinGen TOPMed
rs1422721890 CA373635397	66	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5075594 rs780123925	67	Y>H		No	ClinGen ExAC gnomAD
CA5075593 rs758426304	70	N>S		No	ClinGen ExAC gnomAD
CA5075592 rs745796544	71	K>R		No	ClinGen ExAC TOPMed gnomAD
CA373635343 rs1489175867	74	L>S		No	ClinGen TOPMed gnomAD
rs756739674 CA5075590	76	R>K		No	ClinGen ExAC TOPMed gnomAD
rs780037069 CA194026352	78	R>G		No	ClinGen gnomAD
CA5075589 rs753449637	80	Q>R		No	ClinGen ExAC gnomAD
rs1387674446 CA373635275	84	R>G		No	ClinGen gnomAD
rs771825384 CA5075587	84	R>T		No	ClinGen ExAC gnomAD
TCGA novel	85	D>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373635270 rs751981081	85	D>N		No	ClinGen ExAC TOPMed gnomAD
CA5075584 rs766794109	85	D>V		No	ClinGen ExAC gnomAD
COSM1222400 COSM1222399 CA5075585 rs751981081	85	D>Y	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA373635238 rs1431273304	87	L>F		No	ClinGen gnomAD
rs751634492 CA5075565	87	L>S		No	ClinGen ExAC gnomAD
CA5075564 rs766820950	88	I>V		No	ClinGen ExAC gnomAD
CA373635219 rs1251135772	90	V>A		No	ClinGen gnomAD
CA373635216 rs1417494213	91	T>A		No	ClinGen TOPMed
rs758664175 CA5075563	92	C>F		No	ClinGen ExAC TOPMed gnomAD
rs758664175 CA194025431	92	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs1056097657 CA194025430	101	F>L		No	ClinGen TOPMed
CA5075561 rs765616078	102	T>A		No	ClinGen ExAC gnomAD
rs1051428293 CA194025429	102	T>I		No	ClinGen Ensembl
CA5075559 rs372892120	103	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5075558 rs764266539	104	A>G		No	ClinGen ExAC gnomAD
rs374908460 CA5075555	107	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs779481498 CA5075529	111	L>P		No	ClinGen ExAC gnomAD
rs1484274795 CA373634576	112	I>F		No	ClinGen gnomAD
CA5075527 rs754385559	115	G>D		No	ClinGen ExAC gnomAD
rs1259912871 CA373634443	120	I>V		No	ClinGen gnomAD
CA373634418 rs1588461544	121	K>R		No	ClinGen Ensembl
CA373634407 rs1488198777	122	D>N		No	ClinGen gnomAD
TCGA novel	123	L>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1210809696 CA373634356	124	H>R		No	ClinGen TOPMed gnomAD
rs764319527 COSM1222393 CA5075526 COSM1222394	129	A>S	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA373634278 rs764319527	129	A>T		No	ClinGen ExAC TOPMed gnomAD
CA5075525 rs139747326	130	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5075524 rs752994734	131	T>I		No	ClinGen ExAC gnomAD
CA5075523 rs767585777	133	F>L		No	ClinGen ExAC gnomAD
CA5075522 rs759387441	134	P>S		No	ClinGen ExAC gnomAD
rs773948512 CA5075521	136	S>N		No	ClinGen ExAC gnomAD
rs1320047477 CA373634137 COSM1314889 COSM1314890	137	P>S	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	138	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773108617 CA5075518	142	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs755220044 CA5075503	144	R>*		No	ClinGen ExAC TOPMed gnomAD
rs1012272162 CA194024358	144	R>Q		No	ClinGen TOPMed gnomAD
rs766468864 CA194024357	150	L>P		No	ClinGen Ensembl
rs199855837 CA194024356	152	Q>E		No	ClinGen Ensembl
CA5075500 rs762701250	152	Q>H		No	ClinGen ExAC gnomAD
CA5075501 rs114918767	152	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1214919960 CA373633565	157	P>L		No	ClinGen gnomAD
rs761394172 CA5075497	159	F>S		No	ClinGen ExAC gnomAD
rs1215164133 CA373633541	161	T>S		No	ClinGen TOPMed
CA373633527 rs1442933167	163	G>E		No	ClinGen gnomAD
rs776073842 CA5075496	164	N>S		No	ClinGen ExAC gnomAD
rs1448322257 CA373633499	167	T>K		No	ClinGen TOPMed
CA5075494 rs746691112	169	P>S		No	ClinGen ExAC gnomAD
CA373633445 rs1172878576	170	T>I		No	ClinGen gnomAD
rs775253849 CA5075493	170	T>S		No	ClinGen ExAC TOPMed gnomAD
CA373633415 rs1410874153	172	R>G		No	ClinGen gnomAD
rs999893482 CA194024355	172	R>K		No	ClinGen TOPMed gnomAD
CA373633407 rs999893482	172	R>T		No	ClinGen TOPMed gnomAD
rs771454601 CA5075492	173	A>S		No	ClinGen ExAC gnomAD
rs1414231185 CA373633363	174	Q>H		No	ClinGen TOPMed
CA5075491 rs201222705	174	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1399373232 CA373633358	175	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5075490 rs778437482	175	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA373633333 rs1177435124	176	L>R		No	ClinGen gnomAD
CA373633328 rs1318749440	177	I>V		No	ClinGen TOPMed
rs750174858 CA194024354	181	M>V		No	ClinGen gnomAD
CA194024353 rs892287947	183	V>G		No	ClinGen Ensembl
TCGA novel	185	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5075488 rs374712160	185	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1236254242 CA373633114	187	A>G		No	ClinGen gnomAD
CA5075487 rs781185503	189	G>E		No	ClinGen ExAC gnomAD
CA194024352 rs1032245835	190	R>K		No	ClinGen Ensembl
CA373633051 rs1223277732	191	Y>C		No	ClinGen gnomAD
rs751815682 CA5075485	192	P>R		No	ClinGen ExAC gnomAD
CA5075484 rs766544044	193	S>N		No	ClinGen ExAC gnomAD
TCGA novel	194	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA194024351 rs1000736795	195	Y>C		No	ClinGen Ensembl
CA373632898 rs1358825547	198	W>L		No	ClinGen gnomAD
CA5075482 rs750155479	201	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1253033908 CA373632840	201	R>P		No	ClinGen gnomAD
rs1234795400 CA373632795	203	W>*		No	ClinGen TOPMed
CA373632718 rs1158636594	209	A>T		No	ClinGen gnomAD
CA5075480 rs370720259	209	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1588458469 CA373632676	212	D>Y		No	ClinGen Ensembl
rs763553924 CA5075478	213	V>I		No	ClinGen ExAC gnomAD
rs1380920163 CA373634749	215	I>F		No	ClinGen TOPMed gnomAD
rs1052318040 CA194023401	217	L>R		No	ClinGen TOPMed gnomAD
rs1336154739 CA373634729	218	D>G		No	ClinGen gnomAD
CA5075454 rs759319278	222	S>C		No	ClinGen ExAC TOPMed gnomAD
rs774121222 CA5075453	223	T>A		No	ClinGen ExAC TOPMed gnomAD
CA373634697 rs1190720168	223	T>I		No	ClinGen gnomAD
rs1430136639 CA373634696	224	K>E		No	ClinGen gnomAD
rs770092494 CA5075452	225	H>R		No	ClinGen ExAC
rs1262330743 CA373634686	225	H>Y		No	ClinGen gnomAD
TCGA novel	226	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373951055 CA5075450	228	S>P		No	ClinGen ESP ExAC TOPMed
CA5075449 rs747512469	229	M>L		No	ClinGen ExAC TOPMed gnomAD
COSM1155148 CA5075448 rs747512469 COSM1109739	229	M>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs539470866 CA5075447	230	H>D		No	ClinGen 1000Genomes ExAC gnomAD
CA373634631 rs1251012808	231	V>I		No	ClinGen gnomAD
TCGA novel	235	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1309697105 CA373634577	236	G>E		No	ClinGen gnomAD
CA5075446 rs772119295	236	G>R		No	ClinGen ExAC gnomAD
CA5075444 rs370998856	240	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA373634532 rs370998856	240	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	240	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1369457011 CA373634529	240	R>L		No	ClinGen gnomAD
rs1441056370 CA373634492	243	L>F		No	ClinGen gnomAD
rs375747412 CA194023397	245	K>E		No	ClinGen ESP
rs201080739 CA194023396	246	S>C		No	ClinGen ExAC TOPMed gnomAD
rs201080739 CA5075442	246	S>F		No	ClinGen ExAC TOPMed gnomAD
CA373634453 rs1458512497	247	L>F		No	ClinGen gnomAD
rs777576782 CA5075441	248	I>F		No	ClinGen ExAC TOPMed gnomAD
CA5075440 rs756185228	248	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1463330259 CA373634445	248	I>T		No	ClinGen gnomAD
CA373634422 rs1172797757	250	Q>R		No	ClinGen gnomAD
CA373634414 rs1452449013	251	T>A		No	ClinGen TOPMed gnomAD
rs1254852539 CA373634410	251	T>S		No	ClinGen gnomAD
rs947522177 CA194023395	252	V>M		No	ClinGen TOPMed gnomAD
CA373634397 rs1564128174	253	I>L		No	ClinGen Ensembl
CA194023394 rs7024916	255	S>R		No	ClinGen TOPMed gnomAD
TCGA novel	255	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1194228527 CA373634342	258	M>V		No	ClinGen gnomAD
rs752666910 CA5075439	259	E>G		No	ClinGen ExAC gnomAD
CA5075438 rs767182277	263	L>W		No	ClinGen ExAC gnomAD
CA373634241 rs1336765312	266	E>D		No	ClinGen TOPMed
CA373634235 rs1234058438	267	P>R		No	ClinGen gnomAD
rs189917529 CA5075437	271	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA373634198 rs1346303234	271	P>S		No	ClinGen gnomAD
CA5075436 rs751198592	273	K>Q		No	ClinGen ExAC TOPMed gnomAD
rs766004332 CA5075435	274	D>V		No	ClinGen ExAC gnomAD
CA373634145 rs1326288227	276	E>A		No	ClinGen TOPMed gnomAD
rs1054169209 CA194023392	276	E>D		No	ClinGen TOPMed
rs372609507 CA5075434	277	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs777124790 CA5075433	278	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	283	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1396791862 CA373634037	286	I>M		No	ClinGen TOPMed gnomAD
rs768892342 CA5075432	286	I>V		No	ClinGen ExAC gnomAD
rs368902065 CA5075431	289	P>A		No	ClinGen ESP ExAC gnomAD
CA373633999 rs1260191060	290	H>R		No	ClinGen TOPMed
rs1469563802 CA373633993	291	L>F		No	ClinGen gnomAD
CA5075430 rs145947133	294	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1588446360 CA373633955	297	E>K		No	ClinGen Ensembl
CA5075428 rs199760631	299	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs927579644 CA194023389	300	T>A		No	ClinGen Ensembl
CA194023388 rs866422575	301	D>N		No	ClinGen TOPMed
rs779017088 CA5075426	302	L>F		No	ClinGen ExAC gnomAD
TCGA novel	303	I>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	304	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA194023387 rs942890623	304	D>V		No	ClinGen TOPMed gnomAD
rs1212143245 CA373633896	305	S>C		No	ClinGen gnomAD
rs1564128025 CA373633875	309	H>N		No	ClinGen Ensembl
CA373633837 rs1350608718	314	C>R		No	ClinGen TOPMed gnomAD
CA5075405 rs770899905	317	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs201402192 COSM2778979 CA5075406	317	R>W	large_intestine Variant assessed as Somatic; 5.273e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA5075404 rs749571735	318	H>R		No	ClinGen ExAC TOPMed gnomAD
CA373633406 rs1246586260	325	H>Y		No	ClinGen TOPMed
CA373633396 rs1363772086	326	L>V		No	ClinGen gnomAD
rs769740609 CA5075402	327	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1388913173 CA373633087	328	A>G		No	ClinGen gnomAD
rs943842876 CA194022855	328	A>T		No	ClinGen TOPMed
CA373633079 rs1455004537	329	G>D		No	ClinGen TOPMed
rs1438750520 CA373633071	330	S>F		No	ClinGen gnomAD
rs762899001 CA5075387	330	S>P		No	ClinGen ExAC gnomAD
CA5075384 rs368529571	331	Q>R		No	ClinGen ESP ExAC
rs926740762 CA194022845	335	A>T		No	ClinGen TOPMed
CA5075383 rs200312685	336	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA373633005 rs1564124491	337	E>V		No	ClinGen Ensembl
rs1450233735 CA373632997	338	V>I		No	ClinGen gnomAD
rs776629685 CA5075382	339	D>E		No	ClinGen ExAC gnomAD
rs1453363127 CA373632986	339	D>N		No	ClinGen TOPMed
CA194022843 rs572042956	345	S>G		No	ClinGen Ensembl
rs970869652 CA194022842	345	S>T		No	ClinGen TOPMed
TCGA novel	348	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5075380 rs768553717	351	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA5075379 rs747009679	352	E>G		No	ClinGen ExAC gnomAD
rs779817550 CA5075378	353	T>N		No	ClinGen ExAC
rs955137099 CA194022841	354	K>E		No	ClinGen TOPMed gnomAD
rs745311824 CA5075376	355	R>C		No	ClinGen ExAC gnomAD
CA373632819 rs1246931231	355	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA194022840 rs999400056	358	R>Q		No	ClinGen gnomAD
CA5075375 rs567590269	358	R>W		No	ClinGen 1000Genomes ExAC gnomAD
CA5075374 rs376519073	359	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs958005994 CA194022838	360	P>S		No	ClinGen TOPMed gnomAD
CA373632671 rs1294183236	369	M>V		No	ClinGen gnomAD
CA373632625 rs1206135948	372	R>K		No	ClinGen TOPMed
rs752136183 CA5075370	372	R>S		No	ClinGen ExAC gnomAD
TCGA novel	373	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1352953361 CA373632609	374	I>V		No	ClinGen TOPMed gnomAD
CA373632590 rs1331332218	376	Q>K		No	ClinGen gnomAD
CA373632550 rs1430748957	379	S>Y		No	ClinGen gnomAD
rs766744781 CA5075369	380	T>S		No	ClinGen ExAC TOPMed gnomAD
CA5075368 rs763102615	381	C>F		No	ClinGen ExAC gnomAD
CA194022837 rs746920322	382	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5075367 rs746920322	382	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1455963838 CA373632527	382	R>W		No	ClinGen TOPMed gnomAD
rs762177997 CA5075365	384	V>M		No	ClinGen ExAC TOPMed gnomAD
CA373632501 rs1234214025	385	E>K		No	ClinGen gnomAD
CA194022836 rs996683259	388	R>M		No	ClinGen TOPMed
rs1485187701 CA373632440	391	S>N		No	ClinGen gnomAD
rs1295397358 CA373632434	391	S>R		No	ClinGen TOPMed gnomAD
rs760338614 CA5075362	395	K>E		No	ClinGen ExAC gnomAD
rs1040919144 CA194022835	395	K>I		No	ClinGen TOPMed gnomAD
CA373632357 rs1588440129	398	V>G		No	ClinGen Ensembl
rs1229951829 CA373632346	399	T>I		No	ClinGen TOPMed gnomAD
rs1223257718 CA373632343	400	L>M		No	ClinGen gnomAD
rs1223257718 CA373632344	400	L>V		No	ClinGen gnomAD
rs202195968 CA5075360	401	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA194022834 rs1047228868	402	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs200503740 CA5075358	403	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770404404 CA373632311	403	Q>S		No	ClinGen ExAC TOPMed gnomAD
CA373632306 rs1311429500	403	Q>W		No	ClinGen gnomAD

No associated diseases with Q7Z6K3

4 regional properties for Q7Z6K3

Type	Name	Position	InterPro Accession
repeat	Protein prenyltransferase, alpha subunit	118 - 152	IPR002088-1
repeat	Protein prenyltransferase, alpha subunit	176 - 210	IPR002088-2
repeat	Protein prenyltransferase, alpha subunit	217 - 246	IPR002088-3
repeat	Protein prenyltransferase, alpha subunit	291 - 325	IPR002088-4

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name	Definition
protein prenyltransferase activity	Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein.

1 GO annotations of biological process

Name	Definition
protein prenylation	The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A3KPW7	ptar1	Protein prenyltransferase alpha subunit repeat-containing protein 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MAETSEEVAV	LVQRVVKDIT	NAFRRNPHID	EIGLIPCPEA	RYNRSPIVLV	ENKLGVESWC
70	80	90	100	110	120
VKFLLPYVHN	KLLLYRTRKQ	WLNRDELIDV	TCTLLLLNPD	FTTAWNVRKE	LILSGTLNPI
130	140	150	160	170	180
KDLHLGKLAL	TKFPKSPETW	IHRRWVLQQL	IQETSLPSFV	TKGNLGTIPT	ERAQRLIQEE
190	200	210	220	230	240
MEVCGEAAGR	YPSNYNAWSH	RIWVLQHLAK	LDVKILLDEL	SSTKHWASMH	VSDHSGFHYR
250	260	270	280	290	300
QFLLKSLISQ	TVIDSSVMEQ	NPLRSEPALV	PPKDEEAAVS	TEEPRINLPH	LLEEEVEFST
310	320	330	340	350	360
DLIDSYPGHE	TLWCHRRHIF	YLQHHLNAGS	QLSQAMEVDG	LNDSSKQGYS	QETKRLKRTP
370	380	390	400
VPDSLGLEME	HRFIDQVLST	CRNVEQARFA	SAYRKWLVTL	SQ