Q7Z2H8
PR
Gene name |
SLC36A1 |
Protein name |
Proton-coupled amino acid transporter 1 |
Names |
Proton/amino acid transporter 1, hPAT1, Solute carrier family 36 member 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:206358 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7Z2H8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7Z2H8-F1 | Predicted | AlphaFoldDB |
363 variants for Q7Z2H8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs947195633 CA129919896 |
3 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
CA129919907 rs199948845 |
7 | R>Q | No |
ClinGen 1000Genomes |
|
|
CA3519073 rs761378542 |
7 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA3519074 rs764750192 |
8 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs770381906 CA129919909 |
9 | E>K | No |
ClinGen Ensembl |
|
|
CA129919911 rs895938306 |
10 | D>G | No |
ClinGen Ensembl |
|
|
rs1383273942 CA361806328 |
11 | Y>* | No |
ClinGen gnomAD |
|
|
rs1013817247 CA129919913 |
11 | Y>H | No |
ClinGen gnomAD |
|
|
rs776161656 CA129919918 |
12 | H>L | No |
ClinGen Ensembl |
|
|
rs1454373627 CA361806332 |
12 | H>Y | No |
ClinGen gnomAD |
|
|
CA3519076 rs763518368 |
13 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1581104165 CA361806350 |
13 | D>V | No |
ClinGen Ensembl |
|
|
rs759162243 CA3519077 |
14 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751951454 CA3519078 |
15 | S>G | No |
ClinGen ExAC gnomAD |
|
|
rs1197644667 CA361806376 |
15 | S>I | No |
ClinGen gnomAD |
|
|
rs367921434 CA3519079 |
17 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 19 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs752896616 CA3519081 |
19 | V>M | No |
ClinGen ExAC gnomAD |
|
|
CA361806443 rs1476038565 |
20 | S>G | No |
ClinGen gnomAD |
|
|
rs777859729 CA361806463 |
21 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777859729 CA3519083 |
21 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749397330 CA3519084 |
22 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1470862347 CA361806492 |
23 | E>K | No |
ClinGen gnomAD |
|
|
rs780012452 CA3519086 |
24 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA3519087 rs150947305 |
25 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs775913829 CA3519090 |
26 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1271803683 CA361806542 |
26 | S>P | No |
ClinGen gnomAD |
|
|
CA361806586 rs759011972 |
28 | G>A | No |
ClinGen TOPMed |
|
|
CA129919981 rs759011972 |
28 | G>D | No |
ClinGen TOPMed |
|
| TCGA novel | 29 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs762602455 CA3519093 |
30 | N>K | No |
ClinGen ExAC gnomAD |
|
|
rs766981755 CA3519094 |
31 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs1396419784 CA361806663 |
33 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
CA361806666 rs1396419784 |
33 | S>F | No |
ClinGen TOPMed gnomAD |
|
|
rs752180488 CA361806675 |
34 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752180488 CA3519095 |
34 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767863955 CA3519097 |
35 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767863955 CA361806683 |
35 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3519096 rs759964143 |
35 | P>T | No |
ClinGen ExAC gnomAD |
|
|
CA361806717 rs1315258803 |
37 | S>F | No |
ClinGen gnomAD |
|
|
CA3519099 rs756320184 |
37 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3519100 rs778006483 |
38 | Y>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs753888746 CA3519101 |
39 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs147768311 CA3519102 |
40 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA129920039 rs898559171 |
40 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
rs746909017 CA3519104 |
44 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
TCGA novel CA361806831 rs1401064699 |
44 | S>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
NCI-TCGA ClinGen TOPMed gnomAD |
|
CA361806850 rs754898078 |
45 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs754898078 CA3519105 |
45 | N>H | No |
ClinGen ExAC gnomAD |
|
|
CA3519107 rs747938024 |
45 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3519106 rs527734301 |
45 | N>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs769466345 CA3519108 |
46 | S>I | No |
ClinGen ExAC gnomAD |
|
|
CA3519110 rs748805023 |
48 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs141158515 CA3519111 |
48 | T>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs758794849 CA3519138 |
49 | W>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA129922862 rs1028439777 |
52 | T>N | No |
ClinGen Ensembl |
|
|
rs1485209103 CA361807246 |
53 | L>F | No |
ClinGen gnomAD |
|
| TCGA novel | 53 | L>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 65 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs987289099 CA129922881 |
66 | L>P | No |
ClinGen Ensembl |
|
|
CA361807334 rs1396542672 |
67 | G>* | No |
ClinGen gnomAD |
|
|
rs765483787 CA3519141 |
68 | L>R | No |
ClinGen ExAC gnomAD |
|
|
rs1328799561 CA361807359 |
71 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
rs758468876 CA3519143 |
74 | N>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1198811648 CA361807388 |
74 | N>T | No |
ClinGen TOPMed |
|
|
rs767489274 CA3519144 |
75 | A>E | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 76 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA3519147 rs138099002 |
78 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs138099002 CA3519148 |
78 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA361807552 rs1205764923 |
81 | P>A | No |
ClinGen gnomAD |
|
|
rs1482121272 CA361807630 |
86 | I>F | No |
ClinGen gnomAD |
|
|
CA361807647 rs1258878488 |
87 | I>V | No |
ClinGen TOPMed |
|
|
CA361807680 rs1210931563 |
89 | I>F | No |
ClinGen TOPMed |
|
|
rs1429821555 CA361807697 |
90 | V>M | No |
ClinGen gnomAD |
|
|
COSM1064553 CA3519164 rs751679172 |
92 | V>M | endometrium Variant assessed as Somatic; 4.636e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs559992478 CA3519165 |
93 | H>Y | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA3519167 rs143136105 |
95 | M>V | No |
ClinGen ESP ExAC gnomAD |
|
|
COSM1542660 CA361807793 rs1581131232 |
96 | G>C | lung [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs757175932 CA3519168 |
99 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA129923414 rs371168502 |
102 | A>V | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs372983002 CA3519170 |
103 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs148259317 CA3519171 |
104 | H>R | No |
ClinGen ESP ExAC TOPMed |
|
|
CA3519172 COSM3429165 rs142033033 |
107 | R>C | large_intestine Variant assessed as Somatic; 4.63e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA3519173 rs142033033 |
107 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs769130622 CA3519174 |
107 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769130622 CA361807937 |
107 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs146342711 CA3519198 |
109 | L>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 111 | K>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1223090150 CA361808027 |
112 | S>P | No |
ClinGen gnomAD |
|
| TCGA novel | 115 | D>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1581133344 CA361808087 |
117 | G>D | No |
ClinGen Ensembl |
|
|
rs774767678 CA3519202 |
118 | D>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA361808106 rs1267492653 |
119 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs1253118000 CA361808113 |
120 | V>M | No |
ClinGen gnomAD |
|
|
CA361808134 rs1433597774 |
121 | M>I | No |
ClinGen TOPMed |
|
|
rs1438207012 CA361808140 |
122 | Y>H | No |
ClinGen gnomAD |
|
|
CA3519204 rs772211010 |
129 | C>R | No |
ClinGen ExAC gnomAD |
|
|
rs201820090 CA129923796 |
131 | W>C | No |
ClinGen TOPMed |
|
|
CA361808247 rs568011225 |
132 | L>F | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs530045251 CA3519206 |
132 | L>H | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs568011225 CA3519205 |
132 | L>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs375805253 CA3519209 |
133 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs769924388 CA3519208 |
133 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1160358724 CA361808266 |
134 | N>S | No |
ClinGen TOPMed gnomAD |
|
|
rs765944390 CA3519210 |
135 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3519212 COSM420825 rs201241765 |
136 | A>T | lung Variant assessed as Somatic; 0.0 impact. urinary_tract [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA129923851 rs947498713 |
136 | A>V | No |
ClinGen Ensembl |
|
|
rs1339051691 CA361808301 |
137 | H>Q | No |
ClinGen TOPMed |
|
|
rs1395385062 CA361808323 |
139 | G>E | No |
ClinGen Ensembl |
|
|
rs1287169688 CA361808327 |
140 | R>G | No |
ClinGen gnomAD |
|
|
rs35204299 CA3519231 RCV000881290 |
141 | R>C | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs35204299 CA3519232 |
141 | R>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA361808749 rs1264142918 |
141 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
rs35204299 CA3519233 |
141 | R>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs752123680 CA3519234 |
142 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1208716813 CA361808774 |
143 | V>M | No |
ClinGen gnomAD |
|
|
rs760286242 CA3519235 |
144 | D>N | No |
ClinGen ExAC gnomAD |
|
|
CA361808787 rs760286242 |
144 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1211287889 CA361808856 |
149 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
rs183398364 CA3519237 |
150 | T>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs200612963 CA129925155 |
151 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1387348653 CA361808924 |
154 | F>I | No |
ClinGen TOPMed |
|
| TCGA novel | 162 | L>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA3519239 rs757717990 |
162 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA361809049 rs1429809706 |
162 | L>V | No |
ClinGen gnomAD |
|
|
rs755546492 CA3519238 |
164 | D>G | No |
ClinGen ExAC gnomAD |
|
|
rs758673415 CA3519242 |
165 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA3519243 rs780483564 |
168 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs149813162 CA3519299 |
169 | V>A | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1163360574 CA361809308 |
169 | V>M | No |
ClinGen gnomAD |
|
|
CA3519300 rs766720871 |
170 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA129925630 rs943359511 |
172 | A>V | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs367905880 CA3519302 |
173 | A>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA361809343 rs144783326 |
174 | N>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs560753255 CA3519303 |
174 | N>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1247295702 CA361809347 |
175 | G>E | No |
ClinGen gnomAD |
|
|
rs1235107687 CA361809351 |
176 | T>A | No |
ClinGen gnomAD |
|
|
CA361809350 rs1235107687 |
176 | T>P | No |
ClinGen gnomAD |
|
|
rs1308937138 CA361809359 |
177 | T>N | No |
ClinGen TOPMed |
|
|
CA361809371 rs1240239656 |
179 | N>D | No |
ClinGen TOPMed |
|
|
CA3519305 rs756251690 |
180 | C>R | No |
ClinGen ExAC gnomAD |
|
|
CA361809389 rs1354262892 |
181 | H>R | No |
ClinGen gnomAD |
|
| TCGA novel | 182 | N>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA361809405 rs1273974135 |
183 | N>S | No |
ClinGen gnomAD |
|
|
rs933415871 CA129925646 |
185 | T>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs140124579 CA3519309 |
187 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs758354539 CA3519310 |
188 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3519311 rs368459683 |
189 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA361809451 rs1471516599 |
191 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs907426542 CA129925682 |
191 | T>I | No |
ClinGen TOPMed |
|
|
rs1162325109 CA361809456 |
192 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
CA3519313 rs546760067 |
193 | D>Y | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA3519314 rs571362914 |
194 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1561757835 CA361809477 |
195 | R>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
|
rs538839843 CA3519316 |
195 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA361809491 rs1338842181 |
197 | Y>C | No |
ClinGen gnomAD |
|
|
rs893073741 CA129925710 |
198 | M>I | No |
ClinGen gnomAD |
|
|
CA129925700 rs202198969 |
198 | M>V | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA3519318 rs772875552 |
200 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA361809510 rs772875552 |
200 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1281947647 CA361809512 |
201 | F>I | No |
ClinGen Ensembl |
|
|
rs1441368786 CA361809530 |
203 | P>L | No |
ClinGen gnomAD |
|
|
CA3519319 rs763518344 |
204 | F>C | No |
ClinGen ExAC gnomAD |
|
|
rs1206024484 CA361809554 |
208 | L>M | No |
ClinGen TOPMed |
|
| TCGA novel | 210 | F>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA361809579 rs759872480 |
211 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA361809592 rs1258142974 |
213 | N>K | No |
ClinGen gnomAD |
|
|
CA3519323 rs569154417 |
213 | N>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA361809590 rs569154417 |
213 | N>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1012561541 CA129925747 |
214 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
rs752846011 CA3519324 |
215 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs752846011 CA361809599 |
215 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs371431768 CA3519326 |
215 | R>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs371431768 CA3519325 |
215 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA361809617 rs1478599255 |
218 | S>F | No |
ClinGen gnomAD |
|
|
rs367661783 CA3519328 |
219 | I>T | No |
ClinGen ESP ExAC gnomAD |
|
|
rs753950310 CA3519327 |
219 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3519329 rs371466684 |
221 | S>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs367893924 CA3519330 |
222 | L>P | No |
ClinGen ESP ExAC gnomAD |
|
|
CA3519331 rs754665195 |
225 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA3519333 rs747755817 |
227 | T>N | No |
ClinGen ExAC gnomAD |
|
|
CA3519334 rs769605007 |
228 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA361809732 rs1429934994 |
230 | V>I | No |
ClinGen TOPMed |
|
| TCGA novel | 231 | S>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 232 | L>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1306772621 CA361809773 |
233 | V>G | No |
ClinGen gnomAD |
|
|
CA361809789 rs1257489546 CA361809787 |
234 | M>I | No |
ClinGen gnomAD |
|
|
rs1233675249 CA361809778 |
234 | M>V | No |
ClinGen gnomAD |
|
|
CA361809811 rs1476886279 |
236 | Y>C | No |
ClinGen TOPMed |
|
|
CA129925815 rs765283313 |
237 | Q>* | No |
ClinGen Ensembl |
|
|
CA361809841 rs1199738809 |
238 | F>L | No |
ClinGen gnomAD |
|
|
CA3519336 rs748858498 |
239 | I>T | No |
ClinGen ExAC |
|
|
rs1263286231 CA361809857 |
240 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
rs771458520 CA3519337 |
241 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs1310201712 CA361810469 |
242 | R>K | No |
ClinGen gnomAD |
|
|
rs1368952078 CA361810476 |
243 | I>F | No |
ClinGen TOPMed |
|
| TCGA novel | 245 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA129931985 rs916160321 |
249 | L>F | No |
ClinGen TOPMed |
|
|
CA361810526 rs1456706991 |
250 | P>R | No |
ClinGen gnomAD |
|
|
rs765183392 CA3519373 |
250 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA129931997 rs971397003 |
251 | L>S | No |
ClinGen Ensembl |
|
|
rs1350595918 CA361810528 |
251 | L>V | No |
ClinGen gnomAD |
|
|
CA361810578 rs1413119052 |
258 | Y>C | No |
ClinGen gnomAD |
|
|
rs981851397 CA129932022 |
259 | P>L | No |
ClinGen Ensembl |
|
| TCGA novel | 261 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA3519379 rs756043156 |
264 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs777711037 CA361810624 |
265 | A>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777711037 CA3519380 |
265 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1300570915 CA361810643 |
268 | S>* | No |
ClinGen gnomAD |
|
|
rs756954823 CA3519383 |
271 | G>D | No |
ClinGen ExAC gnomAD |
|
|
rs1279690971 CA361810676 |
273 | G>R | No |
ClinGen gnomAD |
|
|
CA3519385 rs199519900 |
274 | M>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs200362673 CA3519387 |
274 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3519386 rs199519900 |
274 | M>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA129933605 rs868295961 |
275 | V>I | No |
ClinGen Ensembl |
|
| TCGA novel | 279 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs369178329 CA3519405 |
284 | D>A | No |
ClinGen ESP ExAC gnomAD |
|
|
rs369178329 CA3519406 |
284 | D>G | No |
ClinGen ESP ExAC gnomAD |
|
|
CA361810767 rs1191707614 |
285 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA3519408 rs781382215 |
286 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3519407 rs755511746 |
286 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA361810797 rs1159961645 |
290 | L>V | No |
ClinGen gnomAD |
|
|
CA3519413 rs771072619 |
295 | G>S | No |
ClinGen ExAC gnomAD |
|
|
rs774591605 CA3519414 |
295 | G>V | No |
ClinGen ExAC gnomAD |
|
|
rs776266406 CA3519417 |
296 | M>I | No |
ClinGen ExAC gnomAD |
|
|
CA3519416 rs769881015 |
296 | M>T | No |
ClinGen ExAC gnomAD |
|
|
rs760646759 CA3519415 |
296 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764792234 CA3519419 |
299 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1292253473 CA361810860 |
300 | T>I | No |
ClinGen gnomAD |
|
|
rs1210732236 CA361810855 |
300 | T>P | No |
ClinGen gnomAD |
|
|
rs750034329 CA3519420 |
301 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1252100703 CA361810869 |
302 | L>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA3519421 rs199656226 |
302 | L>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA129933717 rs751111599 |
304 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751111599 CA3519423 |
304 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA129933730 rs868368861 |
305 | S>C | No |
ClinGen Ensembl |
|
|
CA361810892 rs755458787 |
306 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1243337568 CA361810897 |
307 | G>R | No |
ClinGen TOPMed |
|
|
CA129933811 rs898801387 |
313 | Q>K | No |
ClinGen Ensembl |
|
|
CA361810943 rs1449723934 |
314 | F>L | No |
ClinGen gnomAD |
|
|
CA361810947 rs1329901405 |
314 | F>S | No |
ClinGen gnomAD |
|
|
rs374804438 CA3519430 |
315 | G>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1245578463 CA361810955 COSM482369 |
316 | A>T | kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA361810979 rs1354542278 |
319 | Q>* | No |
ClinGen gnomAD |
|
| TCGA novel | 320 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs367785938 CA3519432 |
320 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3519434 rs779101845 |
324 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA361811118 rs1161812132 |
328 | N>K | No |
ClinGen TOPMed |
|
|
rs1200528477 CA361811113 |
328 | N>S | No |
ClinGen gnomAD |
|
|
CA3519435 rs745991814 |
329 | C>F | No |
ClinGen ExAC gnomAD |
|
|
CA361811670 rs1581199302 |
331 | L>V | No |
ClinGen Ensembl |
|
|
rs1259751112 CA361811684 |
332 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1275198191 CA361811681 |
332 | Y>H | No |
ClinGen gnomAD |
|
|
CA3519481 rs140884226 |
333 | Q>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs140884226 CA3519480 |
333 | Q>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA361811767 rs1328427638 |
341 | I>V | No |
ClinGen TOPMed |
|
|
CA361811788 rs1382315060 |
342 | G>E | No |
ClinGen gnomAD |
|
| TCGA novel | 344 | F>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs777210168 CA3519488 |
344 | F>V | No |
ClinGen ExAC gnomAD |
|
|
CA129935583 rs1025112273 |
345 | F>I | No |
ClinGen TOPMed gnomAD |
|
|
CA3519490 rs150177899 |
347 | Y>C | No |
ClinGen ESP ExAC gnomAD |
|
|
rs758625230 COSM1435295 CA3519492 |
348 | A>T | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs1179418860 CA361811864 |
348 | A>V | No |
ClinGen gnomAD |
|
|
COSM3697079 rs781266508 CA3519496 |
353 | V>I | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA361811925 rs1463450267 |
354 | P>A | No |
ClinGen TOPMed |
|
|
rs140356275 CA3519497 COSM482370 |
354 | P>L | kidney [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA3519500 rs745696164 |
358 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1352951030 CA361811971 |
358 | I>V | No |
ClinGen TOPMed |
|
|
rs1561778540 CA361812000 |
360 | P>L | No |
ClinGen Ensembl |
|
|
CA3519501 rs771740212 |
360 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs775069582 CA3519502 |
361 | F>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775069582 CA361812007 |
361 | F>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
VAR_048122 rs9687945 RCV000956330 CA3519504 |
362 | F>L | No |
ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs964285577 CA129935647 |
363 | V>G | No |
ClinGen Ensembl |
|
|
rs1425795492 CA361812043 |
365 | R>* | No |
ClinGen gnomAD |
|
|
rs555693703 COSM1542658 CA129935685 |
365 | R>L | lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA3519507 rs555693703 |
365 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA129935690 rs946051880 |
366 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA3519509 rs763295771 |
367 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs751677534 CA361812065 |
368 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA3519511 rs751677534 |
368 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs751677534 CA361812064 |
368 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA129935704 rs936486159 |
369 | H>R | No |
ClinGen Ensembl |
|
|
CA361812091 rs1439884087 |
370 | C>G | No |
ClinGen gnomAD |
|
|
rs1439884087 CA361812090 |
370 | C>R | No |
ClinGen gnomAD |
|
|
CA361812103 rs1241389600 |
371 | E>Q | No |
ClinGen TOPMed |
|
|
CA3519514 rs759780785 |
373 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs895023814 CA129935736 |
374 | V>G | No |
ClinGen Ensembl |
|
| TCGA novel | 374 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1053544056 CA129935734 |
374 | V>M | No |
ClinGen Ensembl |
|
|
CA361812150 rs1379193602 |
375 | D>E | No |
ClinGen TOPMed gnomAD |
|
|
rs376550410 CA3519516 |
379 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3519518 rs183131678 |
379 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs183131678 CA3519517 |
379 | R>L | Variant assessed as Somatic; 0.0001849 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs372327626 CA3519523 |
385 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs780827104 CA3519524 |
386 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs754665585 CA3519541 |
389 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs781059910 CA3519542 |
391 | I>N | No |
ClinGen ExAC gnomAD |
|
|
rs950588284 CA129941119 |
392 | L>F | No |
ClinGen TOPMed |
|
|
rs983734096 CA361813174 |
393 | I>F | No |
ClinGen TOPMed gnomAD |
|
|
CA129941123 rs983734096 |
393 | I>L | No |
ClinGen TOPMed gnomAD |
|
|
rs747809212 CA3519543 |
393 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs1280711708 CA361813186 |
394 | P>L | No |
ClinGen TOPMed |
|
|
CA3519544 rs191784469 |
395 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3519545 rs191784469 |
395 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs749715139 CA3519546 |
395 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA3519547 rs749715139 |
395 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA3519548 rs774560779 |
396 | L>M | No |
ClinGen ExAC gnomAD |
|
|
rs775625105 CA3519551 |
404 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA361813292 rs569783367 |
406 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs569783367 CA3519554 |
406 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
CA3519555 rs764032139 |
409 | S>G | No |
ClinGen ExAC gnomAD |
|
|
CA361813317 rs1229043860 |
409 | S>N | No |
ClinGen TOPMed gnomAD |
|
|
rs891256866 CA129941192 |
410 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA129941208 rs890762873 |
412 | A>V | No |
ClinGen Ensembl |
|
|
CA3519557 rs762767916 |
413 | L>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762767916 CA3519558 |
413 | L>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs762767916 CA361813337 |
413 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1007836542 CA129941225 |
415 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1230610500 CA361813359 |
416 | P>L | No |
ClinGen gnomAD |
|
|
rs200047726 CA3519560 |
417 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA3519559 rs751395217 |
417 | P>S | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 418 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs752345867 CA3519562 |
419 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA361813384 rs1277605934 |
421 | V>F | No |
ClinGen TOPMed |
|
|
rs755818681 CA3519563 |
427 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA361813435 rs777113295 |
429 | M>L | No |
ClinGen ExAC gnomAD |
|
|
rs777113295 CA3519564 |
429 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1348122798 CA361813444 |
430 | S>G | No |
ClinGen TOPMed |
|
|
CA129941254 rs891545261 |
430 | S>T | No |
ClinGen Ensembl |
|
|
rs1326946833 CA361813455 |
431 | P>L | No |
ClinGen gnomAD |
|
|
rs1326946833 CA361813454 |
431 | P>R | No |
ClinGen gnomAD |
|
|
CA3519567 rs779466314 |
434 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA361813507 rs1325641967 |
436 | K>T | No |
ClinGen TOPMed |
|
|
CA129941284 rs1011358441 |
437 | D>A | No |
ClinGen Ensembl |
|
|
rs373055649 CA3519569 |
438 | A>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs373055649 CA3519570 |
438 | A>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA361813561 rs1339999295 |
441 | S>C | No |
ClinGen gnomAD |
|
|
rs377676191 CA3519572 |
442 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA3519575 rs200345930 |
446 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA361813622 rs1187681872 |
447 | G>S | No |
ClinGen gnomAD |
|
|
rs1476704602 CA361813682 |
452 | T>I | No |
ClinGen gnomAD |
|
|
rs150913271 CA3519578 |
453 | Y>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA3519577 rs759566571 |
453 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA129941384 rs764971918 |
455 | A>T | No |
ClinGen Ensembl |
|
|
CA3519579 rs752576710 |
455 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA3519580 rs371200731 |
456 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs756722941 CA3519583 |
457 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
rs753286699 CA3519582 |
457 | Y>H | No |
ClinGen ExAC gnomAD |
|
|
CA3519584 rs756722941 |
457 | Y>S | No |
ClinGen ExAC gnomAD |
|
|
CA129941397 rs376351989 |
460 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA361813772 rs1393621454 |
460 | I>T | No |
ClinGen gnomAD |
|
|
CA129941399 rs963271509 |
461 | Q>E | No |
ClinGen TOPMed |
|
|
rs1280215271 CA361813829 |
464 | N>K | No |
ClinGen TOPMed |
|
|
rs1035953861 CA129941403 |
464 | N>S | No |
ClinGen Ensembl |
|
|
CA3519588 rs140057648 |
470 | N>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA129941408 rs140057648 |
470 | N>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1581233293 CA361813923 |
472 | T>P | No |
ClinGen Ensembl |
|
|
rs1270527689 CA361813941 |
473 | C>Y | No |
ClinGen TOPMed |
|
|
CA361813956 rs1209687095 |
474 | A>T | No |
ClinGen gnomAD |
|
|
CA3519590 rs776844859 |
474 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA361813987 rs1220279503 |
477 | I>Q | No |
ClinGen TOPMed |
|
|
rs1449065514 CA361813990 |
477 | I>W | No |
ClinGen TOPMed gnomAD |
No associated diseases with Q7Z2H8
1 regional properties for Q7Z2H8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Amino acid transporter, transmembrane domain | 46 - 454 | IPR013057 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| alanine transmembrane transporter activity | Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. |
| amino acid transmembrane transporter activity | Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. |
| amino acid:proton symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in). |
| glycine transmembrane transporter activity | Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. |
| L-alanine transmembrane transporter activity | Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. |
| L-amino acid transmembrane transporter activity | Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. |
| L-proline transmembrane transporter activity | Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. |
| proline:proton symporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in). |
| taurine transmembrane transporter activity | Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| alanine transport | The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| amino acid import across plasma membrane | The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. |
| amino acid transmembrane transport | The process in which an amino acid is transported across a membrane. |
| amino acid transport | The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| glycine transport | The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| ion transport | The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| L-alanine transport | The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| proline transmembrane transport | The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore. |
| proline transport | The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| proton transmembrane transport | The directed movement of a proton across a membrane. |
| taurine transport | The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NVC3 | SLC38A7 | Putative sodium-coupled neutral amino acid transporter 7 | Homo sapiens (Human) | PR |
| Q8K4D3 | Slc36a1 | Proton-coupled amino acid transporter 1 | Mus musculus (Mouse) | PR |
| Q924A5 | Slc36a1 | Proton-coupled amino acid transporter 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTQRLRNED | YHDYSSTDVS | PEESPSEGLN | NLSSPGSYQR | FGQSNSTTWF | QTLIHLLKGN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IGTGLLGLPL | AVKNAGIVMG | PISLLIIGIV | AVHCMGILVK | CAHHFCRRLN | KSFVDYGDTV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MYGLESSPCS | WLRNHAHWGR | RVVDFFLIVT | QLGFCCVYFV | FLADNFKQVI | EAANGTTNNC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HNNETVILTP | TMDSRLYMLS | FLPFLVLLVF | IRNLRALSIF | SLLANITMLV | SLVMIYQFIV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QRIPDPSHLP | LVAPWKTYPL | FFGTAIFSFE | GIGMVLPLEN | KMKDPRKFPL | ILYLGMVIVT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ILYISLGCLG | YLQFGANIQG | SITLNLPNCW | LYQSVKLLYS | IGIFFTYALQ | FYVPAEIIIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FFVSRAPEHC | ELVVDLFVRT | VLVCLTCILA | ILIPRLDLVI | SLVGSVSSSA | LALIIPPLLE |
| 430 | 440 | 450 | 460 | 470 | |
| VTTFYSEGMS | PLTIFKDALI | SILGFVGFVV | GTYEALYELI | QPSNAPIFIN | STCAFI |