AiPD: Autoinhibited Protein Database

Gene name	AERO2 (ERO2, At2g38960, T7F6.13)
Protein name	Endoplasmic reticulum oxidoreductin-2
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT2G38960
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

114-190 (Predicted disordered autoinhibitory region) PR

114-190 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7X9I4-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH01966204	17	G>R	No	1000Genomes
ENSVATH13577876	27	I>T	No	1000Genomes
tmp_2_16265537_C_A	28	A>D	No	1000Genomes
ENSVATH13577877	29	A>T	No	1000Genomes
tmp_2_16265577_T_A	41	N>K	No	1000Genomes
ENSVATH14597090	48	S>P	No	1000Genomes
tmp_2_16265784_A_T	66	I>F	No	1000Genomes
tmp_2_16265819_A_T	77	E>D	No	1000Genomes
ENSVATH00265198	96	K>E	No	1000Genomes
tmp_2_16266006_C_T	112	P>L	No	1000Genomes
tmp_2_16266019_T_A	116	D>E	No	1000Genomes
tmp_2_16266116_G_A	149	V>I	No	1000Genomes
tmp_2_16266662_A_T	234	K>M	No	1000Genomes
ENSVATH05680760	254	D>N	No	1000Genomes
tmp_2_16266860_C_T	269	T>M	No	1000Genomes
tmp_2_16266875_G_A	274	R>H	No	1000Genomes
ENSVATH05680763	361	Q>K	No	1000Genomes
ENSVATH01966209	417	A>S	No	1000Genomes
ENSVATH13577921	441	R>I	No	1000Genomes
ENSVATH00265203	457	I>M	No	1000Genomes
tmp_2_16267757_C_G	463	Q>E	No	1000Genomes
tmp_2_16267766_G_T	466	A>S	No	1000Genomes
tmp_2_16267876_G_A	471	R>K	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q7X9I4

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.

Name	Definition
FAD binding	Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
protein-disulfide reductase activity	Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
thiol oxidase activity	Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O2.

Name	Definition
protein folding in endoplasmic reticulum	A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q03103	ERO1	Endoplasmic oxidoreductin-1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9V3A6	Ero1L	Ero1-like protein	Drosophila melanogaster (Fruit fly)	PR
Q96HE7	ERO1A	ERO1-like protein alpha	Homo sapiens (Human)	PR
B1H1F9	ero1a	ERO1-like protein alpha	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q7T3D1	ero1a	ERO1-like protein alpha	Danio rerio (Zebrafish) (Brachydanio rerio)	PR