Q7T3D1

PR
Gene name
ero1a
Protein name
ERO1-like protein alpha
Names
ERO1-L, ERO1-L-alpha, Endoplasmic reticulum oxidoreductase alpha, Endoplasmic reticulum oxidoreductin-1-like protein, Oxidoreductin-1-L-alpha
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

85-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7T3D1

Entry ID Method Resolution Chain Position Source
AF-Q7T3D1-F1 Predicted AlphaFoldDB

No variants for Q7T3D1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7T3D1

No associated diseases with Q7T3D1

1 regional properties for Q7T3D1

Type Name Position InterPro Accession
domain MIP18 family-like 39 - 109 IPR002744

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.

3 GO annotations of molecular function

Name Definition
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
protein-disulfide reductase activity Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
thiol oxidase activity Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O2.

1 GO annotations of biological process

Name Definition
protein folding in endoplasmic reticulum A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q03103 ERO1 Endoplasmic oxidoreductin-1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9V3A6 Ero1L Ero1-like protein Drosophila melanogaster (Fruit fly) PR
Q96HE7 ERO1A ERO1-like protein alpha Homo sapiens (Human) PR
Q7X9I4 AERO2 Endoplasmic reticulum oxidoreductin-2 Arabidopsis thaliana (Mouse-ear cress) PR
B1H1F9 ero1a ERO1-like protein alpha Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
METCVLLLGL FLTSVHVTTA GSAAHRCFCQ VTGTLDDCAC DVETIDKFNN KDIFPKLQKL
70 80 90 100 110 120
LSSDYFRFYK VNLNNGCPFW TDHSQCGLKY CAVKPCSPDE VPEGLKSSSY KYSEKASHDT
130 140 150 160 170 180
EECEKAEKLG AVNGSLSDET RQALEEWKKY DDESDRFCML DDEDSPESQY VDLLLNPERF
190 200 210 220 230 240
TGYKGAEAWR IWNSIYEENC FKPYSVNRPL NPLASNSGDD GQGFYRWLEG LCVEKRAFFR
250 260 270 280 290 300
LISGLHASIN IHLSARYLLD ENWFEMKWGH NVSEFQQRFD EDLTKGEGPK RLRNLYFLYL
310 320 330 340 350 360
IELRALAKIL PYFERSTFQL YTGQDTQDDQ NKKLLLELLH VAKSFPLHFD ETALFAGNNK
370 380 390 400 410 420
EAMKLKEDFK LTFKNISRIM DCVECFKCRL WGKLQTQGLG TALKILFSER QIEAMPNKQH
430 440 450 460 470 480
QSIISAQSAG NCVFVQRFRK NLHKCQRVEE LQIVVVETQT VTVKMFQERA TVQTDMHKHM
TFPMFGYIQ