Q7TQI3
Gene name |
Otub1 |
Protein name |
Ubiquitin thioesterase OTUB1 |
Names |
Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:107260 |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7TQI3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7TQI3-F1 | Predicted | AlphaFoldDB |
16 variants for Q7TQI3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389534561 | 23 | C>F | No | EVA | |
| rs3389489764 | 34 | Q>* | No | EVA | |
| rs3389524060 | 96 | F>Y | No | EVA | |
| rs3389489763 | 106 | D>N | No | EVA | |
| rs3389431188 | 121 | S>G | No | EVA | |
| rs3408983313 | 122 | K>E | No | EVA | |
| rs3408836191 | 123 | E>A | No | EVA | |
| rs3408916575 | 126 | V>G | No | EVA | |
| rs3408916569 | 127 | S>Y | No | EVA | |
| rs3389523221 | 132 | E>D | No | EVA | |
| rs263745290 | 156 | A>G | No | EVA | |
| rs3389502613 | 159 | L>P | No | EVA | |
| rs3389523173 | 165 | Q>L | No | EVA | |
| rs3389517289 | 197 | G>S | No | EVA | |
| rs3389522147 | 234 | E>D | No | EVA | |
| rs3389489750 | 241 | G>D | No | EVA |
No associated diseases with Q7TQI3
1 regional properties for Q7TQI3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | OTU domain | 80 - 271 | IPR003323 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| deNEDDylase activity | An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. |
| deubiquitinase activity | An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| adaptive immune response | An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| negative regulation of double-strand break repair | Any process that stops, prevents or reduces the frequency, rate or extent of double-strand break repair. |
| negative regulation of histone H2A K63-linked ubiquitination | Any process that stops, prevents or reduces the frequency, rate or extent of histone H2A K63-linked ubiquitination. |
| protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
| protein K48-linked deubiquitination | A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q96FW1 | OTUB1 | Ubiquitin thioesterase OTUB1 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAEEPQQQK | QEPLGSDSEG | VNCLAYDEAI | MAQQDRIQQE | IAVQNPLVSE | RLELSVLYKE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YAEDDNIYQQ | KIKDLHKKYS | YIRKTRPDGN | CFYRAFGFSH | LEALLDDSKE | LQRFKAVSAK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKEDLVSQGF | TEFTIEDFHN | TFMDLIEQVE | KQTSVADLLA | SFNDQSTSDY | LVVYLRLLTS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GYLQRESKFF | EHFIEGGRTV | KEFCQQEVEP | MCKESDHIHI | IALAQALSVS | IQVEYMDRGE |
| 250 | 260 | 270 | |||
| GGTTNPHVFP | EGSEPKVYLL | YRPGHYDILY | K |