Q7TPS5
PR
Gene name |
C2cd5 (Cdp138, Kiaa0528) |
Protein name |
C2 domain-containing protein 5 |
Names |
138 kDa C2 domain-containing phosphoprotein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:74741 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7TPS5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7TPS5-F1 | Predicted | AlphaFoldDB |
41 variants for Q7TPS5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388871945 | 36 | T>I | No | EVA | |
| rs3388868298 | 136 | R>S | No | EVA | |
| rs3388833612 | 147 | F>I | No | EVA | |
| rs3388833612 | 147 | F>L | No | EVA | |
| rs3388870555 | 159 | V>M | No | EVA | |
| rs3388859187 | 170 | V>I | No | EVA | |
| rs3388875641 | 178 | W>* | No | EVA | |
| rs3388875685 | 197 | S>T | No | EVA | |
| rs3388868379 | 263 | R>S | No | EVA | |
| rs3388868488 | 282 | G>E | No | EVA | |
| rs3397524782 | 353 | L>P | No | EVA | |
| rs3388865667 | 381 | N>T | No | EVA | |
| rs3388859200 | 383 | D>G | No | EVA | |
| rs3388870521 | 389 | D>V | No | EVA | |
| rs3388871859 | 393 | A>G | No | EVA | |
| rs3388863052 | 419 | S>N | No | EVA | |
| rs3388862551 | 440 | F>C | No | EVA | |
| rs3388867045 | 574 | M>K | No | EVA | |
| rs254192882 | 617 | R>K | No | EVA | |
| rs244392808 | 632 | T>N | No | EVA | |
| rs244392808 | 632 | T>S | No | EVA | |
| rs3388875707 | 637 | S>C | No | EVA | |
| rs3388850663 | 637 | S>T | No | EVA | |
| rs3388868509 | 638 | E>DG* | No | EVA | |
| rs3388830875 | 641 | I>M | No | EVA | |
| rs108156799 | 643 | S>P | No | EVA | |
| rs3388871866 | 648 | P>S | No | EVA | |
| rs3388850621 | 655 | L>P | No | EVA | |
| rs3388862499 | 706 | S>N | No | EVA | |
| rs3396730482 | 716 | N>I | No | EVA | |
| rs3388862553 | 768 | C>S | No | EVA | |
| rs3388869927 | 791 | A>T | No | EVA | |
| rs3388868369 | 870 | A>P | No | EVA | |
| rs3388867118 | 891 | V>F | No | EVA | |
| rs3388862538 | 897 | L>* | No | EVA | |
| rs3388859191 | 898 | S>P | No | EVA | |
| rs1132212600 | 935 | A>T | No | EVA | |
| rs3388850696 | 946 | A>T | No | EVA | |
| rs3388846535 | 950 | A>T | No | EVA | |
| rs3397366551 | 982 | S>I | No | EVA | |
| rs3388872257 | 1013 | E>* | No | EVA |
No associated diseases with Q7TPS5
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| centriolar satellite | A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. |
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| ruffle membrane | The portion of the plasma membrane surrounding a ruffle. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| calcium-dependent phospholipid binding | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to insulin stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| insulin receptor signaling pathway via phosphatidylinositol 3-kinase | An insulin receptor signaling pathway in which the signal is transmitted via the phosphatidylinositol 3-kinase cascade. |
| intracellular protein transmembrane transport | The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. |
| positive regulation of glucose import | Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle. |
| positive regulation of glucose transmembrane transport | Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of protein targeting to membrane | Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. |
| positive regulation of vesicle fusion | Any process that activates or increases the frequency, rate or extent of vesicle fusion. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| vesicle fusion | Fusion of the membrane of a transport vesicle with its target membrane. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPGKLKVKIV | AGRHLPVMDR | ASDLTDAFVE | VKFGNTTFKT | DVYLKSLNPQ | WNSEWFKFEV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDEDLQDEPL | QITVLDHDTY | SANDAIGKVY | IDIDPLLYSE | AATVISGWFP | IYDTIHGIRG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EINVVVKVDL | FNDSNRFRQS | SCGVKFFCTT | SIPKCYRAVV | IHGFVEELVV | NEDPEYQWID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RIRTPRASNE | ARQRLISLMS | GELQRKIGLK | VLEMRGNAVV | GYLQCFDLEG | ESGLVVRAIG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TACTLDKLSS | PAAFLPACSS | PSRELKEIPF | NEDPNPNTHS | SGPSTPLKNQ | TYSFSPSKSY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SRQSSSSDTD | LSLTPKTGMG | SGSAGKEGGP | FKALLRQQTQ | SALEQREFPF | LTLTAFPPGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LVHVGGVVSA | RSVKLLDRIH | NPDEPETRDA | WWAEIRQEIK | SHAKALGCHA | VVGYSESTSI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CEEVCILSAS | GTAAVLNPRF | LQEGTVEGCL | EQRIEENLPV | GCGFCHIPYD | ELNMPFPAHL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TYCYNCRKQK | VPDVLFTTID | LPTDAVVVGK | GCLIQARLCR | LKKKAQAEAN | ATAISNLLPF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MEYEVHTQLM | NKLKLKGMNA | LFGLRIQITV | GETMLMGLAS | ATGVYLAALP | TPGGIQIAGK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TPNDGSYEQH | ISHMQKRIND | TIAKNKELYE | ITPPEVSEEM | IGSPIPEPRQ | RSRLLRSQSE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SSDEVTELDL | SHGKKDAFVL | EIDDTDAMED | VHSLLTDAPP | PSGFYSCNTE | IMPGINNWTS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EIQMFTSVRV | VRLSSLNLTN | QALNKNFNGL | CENLLKSLYF | KLRSMTPCCL | CHVNFTVSLP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EDELIQVTVT | AVAITFDKNQ | ALQTTKPHVE | KSLQRASTDN | EELLQFPLEL | CSDSLPPHPF |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PAAKEHLESA | NSNSGIPAAQ | RAVTVEKASA | MGDGNFRNRS | APPCASPTVG | VVKMTPLSFI |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PGAKITKYLG | IINMFFIRET | TSLREEGGVS | GFLHAFIAEV | FAMVRAHVAA | LGGNAVVSYI |
| 970 | 980 | 990 | 1000 | 1010 | |
| MKQCVFMENP | SKNQAQCLIN | VSGDAVVFVR | DSDLEVMSSQ | QPAANCQPSC | TGEVTT |