Q28BX9

PR
Gene name
c2cd5 (TGas115n11.1)
Protein name
C2 domain-containing protein 5
Names
138 kDa C2 domain-containing phosphoprotein
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:733979
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

610-692 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q28BX9

Entry ID Method Resolution Chain Position Source
AF-Q28BX9-F1 Predicted AlphaFoldDB

No variants for Q28BX9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q28BX9

No associated diseases with Q28BX9

3 regional properties for Q28BX9

Type Name Position InterPro Accession
conserved_site Calreticulin/calnexin, conserved site 98 - 113 IPR018124-1
conserved_site Calreticulin/calnexin, conserved site 130 - 138 IPR018124-2
conserved_site Calreticulin/calnexin, conserved site 242 - 254 IPR018124-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle membrane
  • Cytoplasm, cell cortex
  • Cell membrane
  • Cell projection, ruffle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ruffle membrane The portion of the plasma membrane surrounding a ruffle.

2 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
calcium-dependent phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.

7 GO annotations of biological process

Name Definition
cellular response to insulin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
insulin receptor signaling pathway via phosphatidylinositol 3-kinase An insulin receptor signaling pathway in which the signal is transmitted via the phosphatidylinositol 3-kinase cascade.
intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
positive regulation of glucose transmembrane transport Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of protein targeting to membrane Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
positive regulation of vesicle fusion Any process that activates or increases the frequency, rate or extent of vesicle fusion.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86YS7 C2CD5 C2 domain-containing protein 5 Homo sapiens (Human) PR
Q7TPS5 C2cd5 C2 domain-containing protein 5 Mus musculus (Mouse) PR
10 20 30 40 50 60
MPGKLKVKIV AGRHLPVMDR ASDLTDAFVE VKFGNTTFKT DVYHKSLNPQ WNSEWFKFEV
70 80 90 100 110 120
DDEDLQDEPL QITVLDHDTY SANDAIGKVY IDIDPLLYTE AATVISGWFP IYDTIHGIRG
130 140 150 160 170 180
EISVLVKVDL FNDLNRFRQS SCGVKFFCTT SIPKSYRAVV IHGFVEELVV NEDPEYQWID
190 200 210 220 230 240
RIRTPRASNE ARQRLISLMS GELQRKIGLK VLEMRGNAVV GYLQCFDLEG ESGLVVRAIG
250 260 270 280 290 300
TACTLDKLSN PAPFAPSCNS PCKEIKEAPF IEELNPNTHS SGPSTPLKNQ TYSFSPSKSF
310 320 330 340 350 360
SRQSSSSDTD LSLTPKTGMG SGSAGRDGGA FKALLRQQTQ SALEQREFPF FTLTSFPPTF
370 380 390 400 410 420
LVHVGGVVSA RSVKLLDRIH NPDEPETRDA WWAEIRQEIK SHARALGCHA VVGYSESTSI
430 440 450 460 470 480
CEEVCILSAS GTAAVLNPKF LQEASAEGCL EQRSEETSPT PCAFCHIPYD ELNMPFPANL
490 500 510 520 530 540
TYCCACRKQK VPDVLFTTID LPSDAPVIGK GCLIQARLCR LKKKSQAEAN ATVISSLLPF
550 560 570 580 590 600
MEYELHTQLM NKLKLKGMNG LFGLRIQITV GESMLLGLAS ATGVYLSSLP TPGGIQIAGK
610 620 630 640 650 660
TPSEGSYDQH ISHMQKKINE TIAKNKDLYE INPPEILEET VGSPIPEPRQ RTRLLRSQSE
670 680 690 700 710 720
SSDEAAELDL SHGKKDAFVL EIDDTDAMED VHSLLTDVAP PPGFYSCNTE IMPGINNWIP
730 740 750 760 770 780
NIQMFSSVRV IRLNSTNLTN QTLNKNFNDL CENLLKSLYF KLRSMVPCCL CHVNFTVAVP
790 800 810 820 830 840
EEESIQVAVT AVAITFDKQQ ALQVPKPRPE KPQPRGSDPE EQLQFPLELS SDSPGPSTFS
850 860 870 880 890 900
PARDVPERGG SPAGATQRAV SLDKSSPLAE SHLRHRGGGG GAIPSVTVVK MTPLSFIPGA
910 920 930 940 950 960
KITKFLGIIN MFFIRETTSL REEGGVSGFL HAFICEVFAM VRAHVAALGG NAVVSYIMKQ
970 980 990 1000 1010
CVFMENANKN QAQCLINVSG DAVIFISESE VEAGPGQPTA PGPQSAGVGG DSAT