Q7TNE1
Gene name |
Sugct |
Protein name |
Succinate--hydroxymethylglutarate CoA-transferase |
Names |
SuccinylCoA:glutarate-CoA transferase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:192136 |
EC number |
2.8.3.13: CoA-transferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7TNE1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7TNE1-F1 | Predicted | AlphaFoldDB |
21 variants for Q7TNE1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs48196910 | 40 | E>K | No | EVA | |
| rs3389266023 | 54 | P>A | No | EVA | |
| rs3389266017 | 114 | V>A | No | EVA | |
| rs1133916982 | 118 | K>I | No | EVA | |
| rs3389270173 | 145 | D>G | No | EVA | |
| rs3389266076 | 172 | G>D | No | EVA | |
| rs3389286887 | 175 | A>P | No | EVA | |
| rs3413134898 | 178 | S>Y | No | EVA | |
| rs3389230846 | 199 | V>E | No | EVA | |
| rs3389272741 | 241 | C>S | No | EVA | |
| rs3389286847 | 263 | H>R | No | EVA | |
| rs48636792 | 305 | C>R | No | EVA | |
| rs50196581 | 305 | C>S | No | EVA | |
| rs581235562 | 329 | A>V | No | EVA | |
| rs3413011945 | 343 | S>C | No | EVA | |
| rs3389237652 | 343 | S>N | No | EVA | |
| rs3403984049 | 403 | G>* | No | EVA | |
| rs3403984005 | 403 | G>A | No | EVA | |
| rs243109560 | 411 | K>E | No | EVA | |
| rs223586446 | 413 | V>I | No | EVA | |
| rs3389286859 | 423 | K>R | No | EVA |
No associated diseases with Q7TNE1
No regional properties for Q7TNE1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q7TNE1 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.8.3.13 | CoA-transferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| succinate-hydroxymethylglutarate CoA-transferase activity | Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLWMLARAVA | FRRPGRGLAG | GRGLWTGRPQ | SDCDSMKPLE | GVRILDLTRV | LAGPFATMNL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GDLGAEVIKV | ERPGAGDDTR | SWGPPFVNTE | STYFLSVNRN | KKSIAVNIKD | PRGVRIVKEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AAICDVFVEN | YVPGKLSEMG | LGYEDIDKIA | PHIIYCSITG | YGQTGPMSHR | AGYDAIASAM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SGLMHITGPE | DGDPVRPGVA | MTDLATGLFA | YGAIMAGLLQ | RYRTGKGLFI | DCNLLSSQVA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CLTQVAANYL | IGQKEAKRWG | TAHGSIVPYQ | AFKTKDGYLV | IGAGNNQQFA | VVCKILNLPE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LIDDCKYRTN | HLRVQNRKEL | VKILSARFAE | EVTAKWLCLF | EGSGIPYGPI | NSLKDVFSEA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QVLHNGLVME | MNHPTVGKIS | VPGPAVRYSK | FKMSEAKPPP | LLGQHTRHIL | KEVLRYDEGA |
| 430 | |||||
| IEKLLCSGVI | EQHETK |