Q68FU4

PR
Gene name
Sugct
Protein name
Succinate--hydroxymethylglutarate CoA-transferase
Names
SuccinylCoA:glutarate-CoA transferase
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:361253
EC number
2.8.3.13: CoA-transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-115 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q68FU4

Entry ID Method Resolution Chain Position Source
AF-Q68FU4-F1 Predicted AlphaFoldDB

1 variants for Q68FU4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3323152963 368 V>I No EVA

No associated diseases with Q68FU4

No regional properties for Q68FU4

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q68FU4

Functions

Description
EC Number 2.8.3.13 CoA-transferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
succinate-hydroxymethylglutarate CoA-transferase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9HAC7 SUGCT Succinate--hydroxymethylglutarate CoA-transferase Homo sapiens (Human) PR
Q7TNE1 Sugct Succinate--hydroxymethylglutarate CoA-transferase Mus musculus (Mouse) PR
10 20 30 40 50 60
MLRMLARAVA FRRSGRGQAG GRGLWTGRPQ SDCDSMKPLE GVRILDLTRV LAGPFATMNL
70 80 90 100 110 120
GDLGAEVIKV ERPGAGDDTR SWGPPFVNTE STYFLSVNRN KKSIAVNIKD PRGVRIVKEL
130 140 150 160 170 180
AAICDVFVEN YVPGKLSEMG LGYADIDKIA PHIVYCSITG YGQTGPMSHR AGYDAIASAM
190 200 210 220 230 240
SGLMHITGPE DGDPVRPGVA MTDLATGLFA YGAIMAGLIQ RYRTGKGLFI DCNLLSSQVA
250 260 270 280 290 300
CLTQVAANYL IGQKEAKRWG TAHGSIVPYQ AFKTKDGYLV IGAGNNQQFA VLCKILNLPE
310 320 330 340 350 360
LIDDSKYRTN HLRVQNRKEL VKILSARFAE EVTAKWLCLF EGSGIPYGPI NSLKDVFSEA
370 380 390 400 410 420
QVLHNGLVME MNHPTVGKIS VPGPAVRYSK FKMSEAKPPP LLGQHTRHIL KEVLRYDEGV
430
IGELLCSGVI EQHETE