Q7K3B9

PR
Gene name
CG7544
Protein name
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG7544
EC number
2.1.1.346: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

168-246 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q7K3B9

Entry ID Method Resolution Chain Position Source
AF-Q7K3B9-F1 Predicted AlphaFoldDB

No variants for Q7K3B9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7K3B9

No associated diseases with Q7K3B9

2 regional properties for Q7K3B9

Type Name Position InterPro Accession
domain CDT1 Geminin-binding domain-like 181 - 364 IPR014939
domain DNA replication factor Cdt1, C-terminal 427 - 549 IPR032054

Functions

Description
EC Number 2.1.1.346 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
23S rRNA (adenine(1618)-N(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
rRNA base methylation The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q09357 mett-10 U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase Caenorhabditis elegans PR
10 20 30 40 50 60
MVKTKGNQKI VGMHPRNVLR TQPDYTKMAI KYKDFRQQCQ LELNGKVSVN FRNEKTLREL
70 80 90 100 110 120
TKMLLKEYYD LDVDFAPGSL VPTLALRLNY ILWLEDLMEP LNLQNIRGID IGCGSSCIYS
130 140 150 160 170 180
LLGAKKNGWH MLALESKPQN IEYAKENVKR NHMESLIEVY AQPDNTNIFK SYFEQDQQQL
190 200 210 220 230 240
QYQFCLCNPP FFDSNLPNPL GGNTRNPERR PAPNNARTGS QEELTCVGGE VQFVQRIIDE
250 260 270 280 290 300
SLENKERVRI FTTMLGVKAN VPRILDYLKE LQVANVSTTE FHQGHTTRWA VAWSFHSEPL
QQGTT