Q09357

PR
Gene name
mett-10
Protein name
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
Names
N6-adenosine-methyltransferase mett-10
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.1.1.346: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q09357

Entry ID Method Resolution Chain Position Source
8GU3 X-ray 301 A A 1-314 PDB
AF-Q09357-F1 Predicted AlphaFoldDB

No variants for Q09357

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q09357

No associated diseases with Q09357

No regional properties for Q09357

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q09357

Functions

Description
EC Number 2.1.1.346 Methyltransferases
Subcellular Localization
  • Nucleus
  • Accumulates in nuclei as cells enter meiosis (PubMed:19596901, PubMed:19752194)
  • During meiotic prophase, expression is predominantly nuclear, but does not co-localize with DNA (PubMed:19596901)
  • Recruited to the nucleus by dlc-1, a component of the dynein complex (PubMed:19752194)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
23S rRNA (adenine(1618)-N(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.
mRNA (N6-adenosine)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U.
U6 snRNA (adenine-(43)-N(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(43) in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine(43) in U6 snRNA.

8 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
centrosome cycle The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
negative regulation of mRNA splicing, via spliceosome Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
post-transcriptional regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
rRNA base methylation The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule.
vulval development The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7K3B9 CG7544 U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MSQNNEMHPR NPYRNKPPDF KALAVEYPEF RKFCQYVSNG KVTFDFKKDA AVRCLTQTLL
70 80 90 100 110 120
KKDFNLDVEI PPGHLVPRVP QKLNYCLLID DLLKANKLTK NVIGIDIGTG TSCIHALIGA
130 140 150 160 170 180
RQFNWKFIAT DGDEKSVRVA HENVAKNGLS SSICVVHVNP DVKTVLMDVV NTIPDTDYAF
190 200 210 220 230 240
CMCNPPFFEK GNGDDKFCED ISSSTETYSN RVASEFRTAP HSATFASSAE LFVDGGEVAF
250 260 270 280 290 300
VNRIIDDSVL LRDRIKIYTT MIGRKSSLKP LQNRLQRFGD DVKIMISVLN QGKTKRWMLA
310 320 330 340 350 360
WTFSKSVSLT TIDRPISFQC PKPGLTRLMQ EISILNGRLR QEDTLAIVAE FKCVTWTNQR
370 380 390 400 410 420
ARKRAKAILS ESSIKKAKWN FSNVACQVAF GAGDGKDSYT DAGNFVSSES IPTNNLNAWD
430 440 450 460 470
NASQAYFPLP NGEVPGPIIR IRIQVFSEDS YDSISFELIS GSKQHLHQLV QYLKNLICR