Q76MT4

PR
Gene name
Esf1 (Abtap)
Protein name
ESF1 homolog
Names
ABT1-associated protein
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:366203
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

35-359 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q76MT4

Entry ID Method Resolution Chain Position Source
AF-Q76MT4-F1 Predicted AlphaFoldDB

3 variants for Q76MT4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs197261125 99 K>N No EVA
rs106248096 110 P>L No EVA
rs8146016 582 E>K No EVA

No associated diseases with Q76MT4

1 regional properties for Q76MT4

Type Name Position InterPro Accession
domain NUC153 750 - 778 IPR012580

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
  • Is concomitantly relocalized into discrete nuclear bodies at higher expression
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H501 ESF1 ESF1 homolog Homo sapiens (Human) PR
Q3V1V3 Esf1 ESF1 homolog Mus musculus (Mouse) PR
10 20 30 40 50 60
MSSKQEIMDD QRFRRVSKDP RFWEMPEKDR KVKIDKRFRA MFHDKKFKLN YAVDKRGRPI
70 80 90 100 110 120
SHSTTEDLKR FYDLSDSDSD LSDEESKVLD EKRVKEKKKQ TKKETKSKTP IEEKKKETKK
130 140 150 160 170 180
TDQKDSINKN DLNNSERIQK MKNSHKSPKI DSEVSPKDSE ESLQSRKKKR DTTDLSVEAS
190 200 210 220 230 240
PKGKLRTKDP STSAMVKSST VSGSKAKREK QAVIMAKDNA GRMLHEEAPE EDSDSASELG
250 260 270 280 290 300
RDEESEGEIT SDDRASADDD ENEDEEEEED GEEEEEEEEE EDESDDESDS GPDLARGKGN
310 320 330 340 350 360
VETSSEDEDD LADLFPEEPG FEHAWRELDK DAPRADEITR RLAVCNMDWD RLKAKDLLAL
370 380 390 400 410 420
FNSFKPKGGV VFSVKIYPSE FGKQRMKEEQ IQGPVELLSI PEDAPEKDWA SREKLRDYQF
430 440 450 460 470 480
KRLKYYYAVV ECDSPETASK IYEDCDGLEF ESSCSFIDLR FIPDDITFDD EPKDAASEVD
490 500 510 520 530 540
LTAYKPKYFT SAAMGTSTVE ITWDETDHER ITTLNRKFKK DELLDMDFEA YLASSSEDEE
550 560 570 580 590 600
EVEEAPEGED GVSIEDGKTK KSQKDDEEQI AKYRQLLQVI QEKEKKGKEN DMEMEIKWVP
610 620 630 640 650 660
GLKESAEEMV KNKLEGKDKL TPWEQFLEKK KEKKRLKKKQ KALAEEASED EIPSDVDLND
670 680 690 700 710 720
PYFAEEVKKI GIKKKSMKSA KDGATSEEET ELEKQKAEMA LLVMDEEEDS KKHFNYDKIV
730 740 750 760 770 780
EHQNLSKKKK KQLMKKKELL EDDFEVNVSD ARFQAMYTSH LFNLDPSDPN FKKTKAMEKI
790 800 810 820 830 840
LEEKARHREQ KEERLIQAVE RAQQDTGKPA QKQPMDPALS MLIKSVKNKT EQFQARKKQR
IK