Q76LS9

PR
Gene name
Mindy1 (Fam63a, Ni)
Protein name
Ubiquitin carboxyl-terminal hydrolase MINDY-1
Names
Deubiquitinating enzyme MINDY-1, NF-E2 inducible protein, Protein FAM63A
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:75007
EC number
3.4.19.12: Omega peptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

403-468 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q76LS9

Entry ID Method Resolution Chain Position Source
AF-Q76LS9-F1 Predicted AlphaFoldDB

18 variants for Q76LS9

Variant ID(s) Position Change Description Diseaes Association Provenance
rs255329910 24 N>K No EVA
rs3388644579 50 Q>* No EVA
rs228713706 61 Q>E No EVA
rs3388629035 76 S>G No EVA
rs3388629080 99 E>G No EVA
rs3388649825 107 Q>L No EVA
rs3388644561 115 C>R No EVA
rs3388648673 147 F>V No EVA
rs3388651730 228 I>V No EVA
rs3388648687 245 Q>H No EVA
rs3388646429 274 S>P No EVA
rs3388648689 277 V>L No EVA
rs3388649294 308 E>G No EVA
rs3388636408 311 L>F No EVA
rs3388636451 347 W>* No EVA
rs3388646419 373 S>G No EVA
rs3388642961 425 Y>* No EVA
rs864294483 460 K>R No EVA

No associated diseases with Q76LS9

1 regional properties for Q76LS9

Type Name Position InterPro Accession
domain MINDY deubiquitinase domain 143 - 266 IPR033979

Functions

Description
EC Number 3.4.19.12 Omega peptidases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name Definition
cysteine-type carboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
K48-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.
Lys48-specific deubiquitinase activity Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein.

1 GO annotations of biological process

Name Definition
protein K48-linked deubiquitination A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N5J2 MINDY1 Ubiquitin carboxyl-terminal hydrolase MINDY-1 Homo sapiens (Human) PR
A3KQS4 mindy1 Ubiquitin carboxyl-terminal hydrolase MINDY-1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MEQPQTENPA PSKATSAETV ESENHEALSG PEKHPQDKDG ADADGAAGEQ EPGDQTLPPA
70 80 90 100 110 120
QDGENLECPP PEASSSPPGP ACGTSPKVET AEVCSRPQEL PQSPRIQQPE LDFYCVKWIP
130 140 150 160 170 180
WKGERTPIIT QSTNGPCPLL AIMNILFLQW KVKLPPQKEV ITSDELLTHL GNCLLSIKPQ
190 200 210 220 230 240
EKSEGLQLNF QQNVDDAMTV LPKLATGLDV NVRFTGVSDF EYTPECSIFD LLGIPLYHGW
250 260 270 280 290 300
LVDPQSPEAV SAVGKLSYNQ LVEKIITCKH SSDSNLVTEG LVAEQFLETT AAQLTYHGLC
310 320 330 340 350 360
ELTAAATEDE LSVFFRNNHF STMTKHKSHL YLLVTDQGFL QEEQVVWESL HNVDGDSCFC
370 380 390 400 410 420
DSDFHLSHSL GKSHGAEGGG GSPEKQLQVD QDYLIALSLQ QQQQPQGTLG LSDLELAQQL
430 440 450 460
QQEEYQQQQA VQPVRTRAPS PQGRGATSGR PAGERRQRSK TESDCVLL