A3KQS4

PR
Gene name
mindy1 (fam63a, si:ch211-210h11.5)
Protein name
Ubiquitin carboxyl-terminal hydrolase MINDY-1
Names
Deubiquitinating enzyme MINDY-1, Protein FAM63A
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:563470
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

436-520 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3KQS4

Entry ID Method Resolution Chain Position Source
AF-A3KQS4-F1 Predicted AlphaFoldDB

No variants for A3KQS4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3KQS4

No associated diseases with A3KQS4

2 regional properties for A3KQS4

Type Name Position InterPro Accession
domain MMM1 domain 95 - 420 IPR019411
domain Synaptotagmin-like mitochondrial-lipid-binding domain 194 - 409 IPR031468

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
cysteine-type deubiquitinase activity An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
K48-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.
Lys48-specific deubiquitinase activity Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N5J2 MINDY1 Ubiquitin carboxyl-terminal hydrolase MINDY-1 Homo sapiens (Human) PR
Q76LS9 Mindy1 Ubiquitin carboxyl-terminal hydrolase MINDY-1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MADSCADTVD GEIKGFSEGQ QLNITKNEDL EQTKPQKEAI ANTEESSACV SQIKQDLAPC
70 80 90 100 110 120
KDPPTTTTAS LEDDAKATSS ASVTSKSQDE SEVINSQSYT PSQSEATPSF SMASLEFSEE
130 140 150 160 170 180
NNGVPPDGPL SSAKSARDGN QVSVQENEGA VAGAMRPAEP TMPAYYFVKW ITWKEKKTAV
190 200 210 220 230 240
ITQSENGPCP LIAIMNILLL RWKVKFPAQT EVVTTEELMA HLGECVLSIK PREKAEGMEL
250 260 270 280 290 300
NFQQNMSDAM AVLPKLSTGL DVNVRFTGVS DFEYTPECIV FDLLDIPLYH GWLVDPQSPE
310 320 330 340 350 360
VVSAVGKLSY NQLVEKIIEF KHSTDSSQVS EGLIAEQFLE STATQLSYHG LCELNTTAKE
370 380 390 400 410 420
GELSVFFRNN HFSTMIKHKG HLYLLVTDQG FLQEESVVWE SLHNVEGDGN FCDSDFRLCH
430 440 450 460 470 480
PSQKPSAAAA QPSTQQQQQM QIDQDYLVAM SLQQEQGEAP GPLSDLELAR QLQQEEYQQP
490 500 510
QTQQQQQQQP SAGQMRGQAT SPQGGQRRRE KKEETDCCIL