AiPD: Autoinhibited Protein Database

Q70Z53

Gene name	FRA10AC1 (C10orf4, PRO2972)
Protein name	Protein FRA10AC1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:118924
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-80 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-80 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q70Z53

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q70Z53-F1	Predicted				AlphaFoldDB

255 variants for Q70Z53

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
VAR_087878	110	R>del	NEDGFC [UniProt]	Yes	UniProt
VAR_087879	161	R>del	NEDGFC [UniProt]	Yes	UniProt
VAR_087880	165	E>del	NEDGFC; unknown pathological significance; decreased protein abundance; no effect on protein localization [UniProt]	Yes	UniProt
CA5610967 rs780617472	2	H>D		No	ClinGen ExAC TOPMed gnomAD
rs148753292 CA5610966	2	H>R		No	ClinGen ESP ExAC gnomAD
rs780617472 CA377614908	2	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA5610965 rs750806040	3	G>S		No	ClinGen ExAC gnomAD
CA377614801 rs1181085479	5	G>E		No	ClinGen TOPMed gnomAD
CA377614797 rs1181085479	5	G>V		No	ClinGen TOPMed gnomAD
CA377614790 rs1440646764	6	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA377614761 rs1252809933	7	Y>C		No	ClinGen gnomAD
CA211557422 rs780614089	8	D>H		No	ClinGen gnomAD
TCGA novel	11	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377614680 rs1413102993	11	F>V		No	ClinGen gnomAD
CA5610964 rs112324577	12	S>C		No	ClinGen ExAC
rs112324577 CA211557418	12	S>G		No	ClinGen ExAC
CA377614663 rs755801351	12	S>N		No	ClinGen ExAC TOPMed gnomAD
CA5610963 rs755801351	12	S>T		No	ClinGen ExAC TOPMed gnomAD
CA5610962 rs370730202	13	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA377614652 rs1204564498	13	D>Y		No	ClinGen gnomAD
CA377614637 rs1253279086	14	D>G		No	ClinGen TOPMed
CA377614617 rs1283740039	16	R>C		No	ClinGen gnomAD
rs726817 VAR_023237 CA5610961	16	R>H		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs764976937	17	C>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1354110221 CA377614595	19	E>*		No	ClinGen gnomAD
CA377614593 rs1354110221	19	E>K		No	ClinGen gnomAD
CA5610958 rs751094541	20	S>F		No	ClinGen ExAC gnomAD
rs751094541 CA5610959	20	S>Y		No	ClinGen ExAC gnomAD
CA5610957 rs766322360	21	S>N		No	ClinGen ExAC TOPMed gnomAD
rs762922773 CA5610956	21	S>R		No	ClinGen ExAC gnomAD
CA377614566 rs766322360	21	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1048572154 CA211557374	22	K>E		No	ClinGen TOPMed
TCGA novel	22	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1207803193 CA377614538	23	R>K		No	ClinGen gnomAD
TCGA novel	23	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377614515 rs1420909931	25	K>E		No	ClinGen gnomAD
CA377614500 rs1188233824	26	R>G		No	ClinGen TOPMed
rs755202796	26	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA377614496 rs1564823640	26	R>K		No	ClinGen Ensembl
rs146587772 CA5610938	26	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs567324774 CA5610937	27	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA377614368 rs1426375070	27	T>I		No	ClinGen gnomAD
rs1488177093 CA377614341	31	D>G		No	ClinGen TOPMed
CA377614337 rs1477001026	32	L>I		No	ClinGen gnomAD
rs146017777 CA5610935	32	L>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1474923800 CA377614288	36	K>N		No	ClinGen gnomAD
CA377614261 rs1262093839	38	F>L		No	ClinGen TOPMed
rs758291299 CA5610933	38	F>L		No	ClinGen ExAC gnomAD
rs528385550 CA5610932	39	Q>E		No	ClinGen 1000Genomes ExAC gnomAD
CA377614253 rs1475338275	39	Q>R		No	ClinGen TOPMed
rs1166386016 CA377614226	41	E>G		No	ClinGen TOPMed
rs1045147141 CA377614196	43	H>L		No	ClinGen TOPMed gnomAD
rs1045147141 CA211555832	43	H>R		No	ClinGen TOPMed gnomAD
rs905733675 CA211555849	43	H>Y		No	ClinGen Ensembl
rs565869916 CA211555826	44	G>*		No	ClinGen 1000Genomes ExAC gnomAD
CA211555825 rs1053397215	44	G>E		No	ClinGen TOPMed gnomAD
rs565869916 CA5610931	44	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA377614151 rs1279705261	45	K>N		No	ClinGen gnomAD
CA211555819 rs112607551	46	V>A		No	ClinGen Ensembl
rs1002668425 CA211555822	46	V>L		No	ClinGen TOPMed gnomAD
CA377614140 rs1002668425	46	V>M		No	ClinGen TOPMed gnomAD
rs1282924209 CA377612748	50	Q>*		No	ClinGen gnomAD
CA377612683 rs1486774113	58	R>G		No	ClinGen gnomAD
CA5610929 rs761599921	58	R>K		No	ClinGen ExAC gnomAD
CA5610913 rs765156157	58	R>S		No	ClinGen ExAC gnomAD
rs1392090505 CA377612631	59	E>K		No	ClinGen TOPMed
TCGA novel	59	E>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377612558 rs1374673723	65	R>S		No	ClinGen TOPMed
rs763835906 CA5610910	67	H>Q		No	ClinGen ExAC gnomAD
rs1201946828 CA377612540	68	L>F		No	ClinGen Ensembl
CA377612532 rs1240099114	69	I>T		No	ClinGen TOPMed
rs1178863615 CA377612527	70	A>D		No	ClinGen gnomAD
rs760914941 CA5610909	70	A>T		No	ClinGen ExAC TOPMed gnomAD
rs764023586 CA211555666	71	M>T		No	ClinGen gnomAD
CA5610908 rs752889902	71	M>V		No	ClinGen ExAC TOPMed gnomAD
CA377612513 rs1223037130	72	D>G		No	ClinGen TOPMed gnomAD
CA377612505 rs1253939433	73	A>T		No	ClinGen TOPMed
CA377612497 rs1321824334	73	A>V		No	ClinGen gnomAD
rs1276451237 CA377635103	74	Y>C		No	ClinGen TOPMed gnomAD
rs1276451237 CA377635102	74	Y>S		No	ClinGen TOPMed gnomAD
rs1401935041 CA377635081	77	H>R		No	ClinGen gnomAD
CA5610888 rs137880326	78	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs2275438 VAR_023238 CA5610887	78	T>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA5610885 rs766594449	80	F>C		No	ClinGen ExAC gnomAD
rs766594449 CA5610884	80	F>S		No	ClinGen ExAC gnomAD
CA5610881 rs146931399	81	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5610882 rs146931399	81	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA377635048 rs1422269388	82	N>K		No	ClinGen TOPMed gnomAD
rs148823401 CA5610880	83	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771692369 CA5610878 COSM686059	84	Y>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs377557297 CA5610876	87	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	88	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5610875 rs770374356	88	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA377635001 rs1205987621	89	G>A		No	ClinGen gnomAD
CA377634999 rs1205987621	89	G>D		No	ClinGen gnomAD
CA377634991 rs1481931805	91	K>E		No	ClinGen TOPMed
CA5610873 rs540524259	91	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs946059597 CA377634971	93	E>D		No	ClinGen TOPMed
TCGA novel	93	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1341230462 CA377634956	95	F>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA5610871 rs201459566	95	F>V		No	ClinGen ExAC TOPMed gnomAD
CA5610870 rs376358924	96	K>R		No	ClinGen ExAC TOPMed gnomAD
CA5610869 rs781170792	97	R>C		No	ClinGen ExAC TOPMed gnomAD
rs373087843 CA5610868	97	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1589727728 CA377634933	99	G>E		No	ClinGen Ensembl
CA5610849 rs148213269	100	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs544149412 CA5610848	100	E>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1236774698 CA377634907	101	N>S		No	ClinGen gnomAD
CA5610847 rs376929060	102	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1180739662 CA377634899	102	D>G		No	ClinGen gnomAD
CA5610845 rs374011831	103	K>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1396681543 CA377634887	104	T>S		No	ClinGen gnomAD
rs770776708 CA5610844	107	D>G		No	ClinGen ExAC TOPMed gnomAD
CA377634864 rs770776708	107	D>V		No	ClinGen ExAC TOPMed gnomAD
rs575052590 CA5610843	108	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs941295037 CA211575606	109	I>T		No	ClinGen TOPMed gnomAD
CA5610842 rs555127846	110	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA211575605 rs980868001	110	R>Q		No	ClinGen TOPMed gnomAD
CA377634838 rs1280507005	112	N>D		No	ClinGen TOPMed
rs764388352 CA5610841	113	H>N		No	ClinGen ExAC gnomAD
CA377634830 rs1486369232	113	H>R		No	ClinGen TOPMed
rs764388352 CA211575599	113	H>Y		No	ClinGen ExAC gnomAD
rs1335915238 CA377634818	115	F>I		No	ClinGen gnomAD
TCGA novel	116	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377634809 rs1208029670	116	L>V		No	ClinGen TOPMed
CA5610840 rs761034126	118	N>S		No	ClinGen ExAC gnomAD
CA377634775 rs1236859861	120	E>D		No	ClinGen TOPMed
rs775993516 CA5610839	121	D>N		No	ClinGen ExAC TOPMed gnomAD
rs765938342 CA5610838	122	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1419692241 CA377634758	123	M>V		No	ClinGen gnomAD
TCGA novel	124	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377634735 rs762703626 CA5610837	125	M>I		No	ClinGen ExAC gnomAD
CA377634740 rs1378840768	125	M>V		No	ClinGen gnomAD
CA5610836 rs772552456 CA377634728	127	W>R		No	ClinGen ExAC gnomAD
rs1308818474 CA377634690	130	R>K		No	ClinGen TOPMed
rs1192957627 CA377634674	132	A>D		No	ClinGen gnomAD
rs947403729 CA211575334	135	Y>C		No	ClinGen TOPMed
CA211575324 rs556506794	138	K>E		No	ClinGen Ensembl
rs1236623178 CA377634626	139	L>V		No	ClinGen TOPMed
rs376592865 CA5610815	143	Y>H		No	ClinGen ESP ExAC TOPMed
CA5610814 rs760707865	144	C>Y		No	ClinGen ExAC gnomAD
CA377634581 rs1447329236	145	I>V		No	ClinGen gnomAD
rs372025705 CA5610813	147	D>G		No	ClinGen ESP ExAC gnomAD
rs771926105 CA377634561	148	L>F		No	ClinGen ExAC TOPMed gnomAD
CA5610812 rs771926105	148	L>V		No	ClinGen ExAC TOPMed gnomAD
CA5610810 rs779202692	151	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs746020734 CA5610811	151	Y>C		No	ClinGen ExAC gnomAD
rs1217441395 CA377634515	154	N>S		No	ClinGen gnomAD
CA211573027 rs762272439	156	F>Y		No	ClinGen Ensembl
CA5610788 rs749540270	160	W>*		No	ClinGen ExAC gnomAD
COSM921621 rs199549545 CA5610787	161	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
COSM921619 CA5610786 rs769873184	161	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5610785 rs748532955	162	V>G		No	ClinGen ExAC gnomAD
TCGA novel	162	V>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781719546 CA5610784	164	K>I		No	ClinGen ExAC gnomAD
rs747377283 CA5610781	165	E>D		No	ClinGen ExAC
CA5610780 rs200756785	166	V>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756931045 CA5610778	169	G>R		No	ClinGen ExAC gnomAD
rs151040677 CA5610777	170	K>R		No	ClinGen 1000Genomes ExAC gnomAD
rs763642429 CA5610776	171	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	173	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA377634358 rs1305612681	175	C>R		No	ClinGen TOPMed
rs374981748 CA5610752	181	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA211571979 rs982919249	184	E>Q		No	ClinGen TOPMed gnomAD
TCGA novel	184	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1194330815 CA377634267	187	K>R		No	ClinGen TOPMed
CA5610749 CA377634257 rs762729942	188	S>R		No	ClinGen ExAC TOPMed gnomAD
CA211571938 rs1026729291	193	F>C		No	ClinGen TOPMed gnomAD
rs773047436 CA5610748	195	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1261740768 CA377634204	196	I>V		No	ClinGen gnomAD
CA5610747 rs765474094	198	H>R		No	ClinGen ExAC TOPMed gnomAD
rs149181398 COSM921609 CA211571937	198	H>Y	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA gnomAD
rs761981204 CA5610746	199	G>V		No	ClinGen ExAC gnomAD
CA211571925 rs546505041	200	E>K		No	ClinGen Ensembl
rs776731975 COSM1638692 CA5610745	201	K>N	stomach [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA5610744 rs768641121	203	N>Y		No	ClinGen ExAC gnomAD
rs750462341	207	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs747462128 CA5610743	207	K>T		No	ClinGen ExAC gnomAD
CA5610720 rs147730663	213	E>D		No	ClinGen ESP ExAC gnomAD
TCGA novel	213	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760164099 CA5610719	216	I>L		No	ClinGen ExAC gnomAD
rs1476257929 CA377634050	217	K>E		No	ClinGen TOPMed
CA377634032 rs1463100071	219	N>S		No	ClinGen gnomAD
CA377634025 rs1374090365	220	F>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs771208599 CA5610717	221	H>P		No	ClinGen ExAC gnomAD
CA377634017 rs771208599	221	H>R		No	ClinGen ExAC gnomAD
CA5610697 rs545360784	227	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA377633944 rs1554894627	229	S>*		No	ClinGen Ensembl
CA377633947 rs1216417216	229	S>A		No	ClinGen Ensembl
rs773672925 CA5610696	230	K>N		No	ClinGen ExAC gnomAD
rs775948504	232	R>E	Variant assessed as Somatic; 0.0003162 impact. [NCI-TCGA]	No	NCI-TCGA
CA5610694 rs746694549	232	R>G		No	ClinGen ExAC gnomAD
COSM1196744 CA211569467 rs971699309	234	D>G	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA377633913 rs1318313661	234	D>N		No	ClinGen TOPMed
rs1402555863 CA377633905	235	K>E		No	ClinGen gnomAD
CA377633900 rs1243994568	235	K>N		No	ClinGen gnomAD
rs774931601 CA5610691	236	T>N		No	ClinGen ExAC gnomAD
rs771583990 CA5610690	237	K>E		No	ClinGen ExAC gnomAD
CA5610689 rs745751956	238	K>E		No	ClinGen ExAC gnomAD
CA377633879 rs1160507401	239	D>H		No	ClinGen gnomAD
CA5610687 rs375390820	240	C>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA5610688 rs375390820	240	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1282608434 CA377633871	240	C>Y		No	ClinGen TOPMed
CA377633834 rs1196798390	245	H>P		No	ClinGen gnomAD
rs1359027470 CA377633829	246	K>E		No	ClinGen TOPMed
CA377633817 rs1244894190	247	K>I		No	ClinGen TOPMed
TCGA novel	247	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1481473458 CA377633822	247	K>Q		No	ClinGen gnomAD
rs1589718496 CA377633810	248	S>C		No	ClinGen Ensembl
rs11187583 CA5610686 VAR_056872	251	S>F		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs777753842 CA5610685	252	S>F		No	ClinGen ExAC TOPMed gnomAD
rs767204685 CA5610684	254	E>V		No	ClinGen ExAC TOPMed gnomAD
CA377633767 rs1350850532	255	E>G		No	ClinGen gnomAD
rs1387512731 CA377633759	256	A>D		No	ClinGen gnomAD
rs7914441 CA5610682	258	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5610681 rs147872799	261	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA377633726 rs1221098366	261	D>N		No	ClinGen gnomAD
CA377633312 rs1408313682	263	G>E		No	ClinGen gnomAD
rs1189055688 CA377633711	263	G>R		No	ClinGen TOPMed
rs1408313682 CA377633310	263	G>V		No	ClinGen gnomAD
CA5610656 rs376966901	264	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5610657 rs750934916	264	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs762152272 CA5610655	271	E>K		No	ClinGen ExAC gnomAD
CA377633250 rs1276820262	272	D>E		No	ClinGen TOPMed
rs777045735 CA5610654	272	D>G		No	ClinGen ExAC TOPMed gnomAD
rs767124356 CA5610653	274	L>P		No	ClinGen ExAC gnomAD
CA377633242 rs1243409833	274	L>V		No	ClinGen gnomAD
rs371654560 CA5610652	275	L>H		No	ClinGen ESP ExAC gnomAD
CA377632710 rs1436016389	276	R>K		No	ClinGen gnomAD
CA377632651 rs1471009276	279	D>A		No	ClinGen gnomAD
CA211562647 rs867326098	279	D>H		No	ClinGen TOPMed
rs1404235439 CA377632616	281	E>G		No	ClinGen gnomAD
CA5610593 rs34803976	283	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs34803976 CA5610592	283	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746108287 CA5610591	284	A>P		No	ClinGen ExAC TOPMed gnomAD
CA5610589 rs774371942	288	E>V		No	ClinGen ExAC gnomAD
rs1589711533 CA377632513	289	L>F		No	ClinGen Ensembl
rs1449629557 CA377632512	289	L>R		No	ClinGen gnomAD
CA5610588 rs770999518	290	W>*		No	ClinGen ExAC gnomAD
CA377632502 rs770999518	290	W>C		No	ClinGen ExAC gnomAD
rs1483504382 CA377632486	293	P>A		No	ClinGen gnomAD
CA211562596 rs916705015	295	P>L		No	ClinGen TOPMed
CA377632468 rs1462306811	296	E>A		No	ClinGen gnomAD
CA377632467 rs1462306811	296	E>G		No	ClinGen gnomAD
TCGA novel	300	K>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1201531590 CA377632433	301	S>T		No	ClinGen TOPMed gnomAD
CA5610585 rs778326425	302	Q>*		No	ClinGen ExAC gnomAD
rs774567501 CA5610566	306	F>L		No	ClinGen ExAC
rs1280172959 CA377632370	307	D>E		No	ClinGen TOPMed
CA377632364 rs1410173678	308	E>D		No	ClinGen gnomAD
rs771197579 CA5610565	308	E>K		No	ClinGen ExAC gnomAD
rs374903280 CA5610564	311	Q>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs1380509862 CA377632335	312	D>N		No	ClinGen gnomAD
CA211561806 rs891110649	314	F>C		No	ClinGen TOPMed
rs1302697633 CA377632310	316	L>R		No	ClinGen gnomAD

No associated diseases with Q70Z53

No regional properties for Q70Z53

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q70Z53

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
phosphatase activity	Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.

1 GO annotations of biological process

Name	Definition
dephosphorylation	The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P15309	ACP3	Prostatic acid phosphatase	Homo sapiens (Human)	PR
Q8BP78	Fra10ac1	Protein FRA10AC1 homolog	Mus musculus (Mouse)	PR
Q5FVF1	Fra10ac1	Protein FRA10AC1 homolog	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MHGHGGYDSD	FSDDERCGES	SKRKKRTVED	DLLLQKPFQK	EKHGKVAHKQ	VAAELLDREE
70	80	90	100	110	120
ARNRRFHLIA	MDAYQRHTKF	VNDYILYYGG	KKEDFKRLGE	NDKTDLDVIR	ENHRFLWNEE
130	140	150	160	170	180
DEMDMTWEKR	LAKKYYDKLF	KEYCIADLSK	YKENKFGFRW	RVEKEVISGK	GQFFCGNKYC
190	200	210	220	230	240
DKKEGLKSWE	VNFGYIEHGE	KRNALVKLRL	CQECSIKLNF	HHRRKEIKSK	KRKDKTKKDC
250	260	270	280	290	300
EESSHKKSRL	SSAEEASKKK	DKGHSSSKKS	EDSLLRNSDE	EESASESELW	KGPLPETDEK
310
SQEEEFDEYF	QDLFL