AiPD: Autoinhibited Protein Database

Q6ZS11

Gene name	RINL
Protein name	Ras and Rab interactor-like protein
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:126432
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

368-438 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

368-438 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q6ZS11

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6ZS11-F1	Predicted				AlphaFoldDB

511 variants for Q6ZS11

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA308150819 rs955326455	2	A>T		No	ClinGen Ensembl
CA405727880 rs1275298076	6	D>G		No	TOPMed ClinGen
rs1203845914 CA405727823	14	E>D		No	TOPMed ClinGen
CA405727819 rs1320882862	15	G>E		No	ClinGen gnomAD
CA405727821 CA405727822 rs1366892108	15	G>R		No	TOPMed gnomAD ClinGen
CA405727820 rs1366892108	15	G>W		No	ClinGen TOPMed gnomAD
CA405727814 rs1383123778	16	V>L		No	gnomAD ClinGen
rs1407185308 CA405727784	19	V>D		No	ClinGen TOPMed gnomAD
rs780407478 CA9421453	19	V>I		No	ClinGen ExAC gnomAD
rs1303137016 CA405727772	21	P>Q		No	ClinGen gnomAD
rs1166944456 CA405727775	21	P>S		No	TOPMed ClinGen
rs1247098052 CA405727767	22	Q>*		No	gnomAD ClinGen
rs1600097177 CA405727759	23	V>G		No	ClinGen Ensembl
rs770249044 CA9421452	23	V>M		No	ClinGen ExAC TOPMed gnomAD
CA9421451 rs1001413	24	N>D		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA405727756 rs1001413	24	N>H		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA405727753 rs1199832248	24	N>S		No	TOPMed gnomAD ClinGen
CA405727736 rs1168595414	26	A>V		No	ClinGen gnomAD
rs777246039 CA9421450	27	D>N		No	ExAC gnomAD ClinGen
CA405727720 rs1345545340	29	T>A		No	gnomAD ClinGen
CA405727710 rs1276409264	30	P>L		No	ClinGen TOPMed gnomAD
CA405727713 rs1200707731	30	P>S		No	ClinGen TOPMed gnomAD
rs1268091070 CA405727669	37	L>P		No	gnomAD ClinGen
CA405727664 rs1220075487	38	E>G		No	ClinGen TOPMed gnomAD
CA405727658 rs769778468	39	P>S		No	TOPMed gnomAD ClinGen
rs769778468 CA308150790	39	P>T		No	TOPMed gnomAD ClinGen
rs1273037741 CA405727653	40	L>V		No	ClinGen TOPMed gnomAD
CA308150789 rs551555322	42	R>C		No	ClinGen 1000Genomes TOPMed gnomAD
CA9421449 rs757988457	42	R>H		No	ExAC TOPMed gnomAD ClinGen
rs776068368 CA9421448	45	R>K		No	ExAC TOPMed gnomAD ClinGen
rs1297205502 CA405727620	45	R>S		No	gnomAD ClinGen
rs1225717910 CA405727608	47	W>L		No	ClinGen gnomAD
CA308150787 rs1038777124	48	G>R		No	ClinGen TOPMed gnomAD
CA405727604 rs1038777124	48	G>W		No	TOPMed gnomAD ClinGen
CA405727597 rs1286151369	49	V>L		No	TOPMed ClinGen
CA405727577 rs1283041666	51	H>Q		No	ClinGen gnomAD
CA405727584 rs1346608487	51	H>Y		No	ClinGen gnomAD
rs1445059514 CA405727574	52	V>M		No	ClinGen TOPMed
CA405727557 rs1329590229	54	E>D		No	gnomAD ClinGen
rs1356827626 CA405727564	54	E>Q		No	gnomAD ClinGen
CA405727556 rs1409507504	55	L>M		No	ClinGen gnomAD
rs1174602083 CA405727535	58	Q>*		No	ClinGen gnomAD
CA405727522 rs1192026752	59	D>E		No	TOPMed ClinGen
CA9421446 rs754601875	60	A>S		No	ExAC TOPMed gnomAD ClinGen
CA308150783 rs754601875	60	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1428269889 CA405727518	60	A>V		No	ClinGen TOPMed gnomAD
CA308150778 rs934170065	64	V>A		No	ClinGen TOPMed gnomAD
rs934170065 CA405727495	64	V>E		No	ClinGen TOPMed gnomAD
rs770580434 CA405727497	64	V>L		No	ClinGen gnomAD
rs770580434 CA308150780	64	V>M		No	ClinGen gnomAD
rs759612168 CA308150776	66	L>Q		No	TOPMed ClinGen
rs750434305 CA9421442	70	G>V		No	ClinGen ExAC
CA308150295 rs529735559	73	L>F		No	1000Genomes ClinGen
CA405727420 rs1223661766	74	V>A		No	ClinGen gnomAD
CA405727424 rs1282434713	74	V>I		No	gnomAD ClinGen
CA405727413 rs1349190247	75	T>R		No	ClinGen gnomAD
rs1392439172 CA405727410	76	G>R		No	TOPMed ClinGen
CA405727404 rs1317198732	77	R>C		No	ClinGen TOPMed gnomAD
rs1317198732 CA405727405	77	R>G		No	ClinGen TOPMed gnomAD
CA308150292 rs999701905	77	R>H		No	ClinGen gnomAD
rs1317198732 CA405727406	77	R>S		No	ClinGen TOPMed gnomAD
CA405727396 rs1600094442	78	D>A		No	ClinGen Ensembl
CA308150290 rs866128061	78	D>E		No	ClinGen Ensembl
CA405727399 rs1341223724	78	D>Y		No	ClinGen gnomAD
CA9421438 rs768863302	79	P>L		No	ClinGen ExAC TOPMed gnomAD
CA405727372 rs1432629227	82	A>T		No	ClinGen gnomAD
CA405727370 rs1345492975	82	A>V		No	gnomAD ClinGen
rs1568388341 CA405727343	86	R>S		No	Ensembl ClinGen
rs1364274866 CA405727337	87	S>L		No	TOPMed gnomAD ClinGen
rs61740709 CA308150277	93	E>*		No	ClinGen 1000Genomes TOPMed gnomAD
rs61740709 CA308150278	93	E>K		No	1000Genomes TOPMed gnomAD ClinGen
rs1447483450 CA405727280	96	T>I		No	TOPMed gnomAD ClinGen
CA405727281 rs1447483450	96	T>N		No	TOPMed gnomAD ClinGen
rs947664784 CA308150276	98	Q>K		No	ClinGen Ensembl
rs1387059864 CA405727237	102	I>T		No	ClinGen TOPMed gnomAD
rs1211711833 CA405727225	104	R>T		No	ClinGen TOPMed
rs767418003 CA9421424	109	E>K		No	ClinGen ExAC gnomAD
rs1568387388 CA405727173	110	S>F		No	ClinGen Ensembl
rs1289618182 CA405727160	112	N>K		No	ClinGen gnomAD
rs370724276 CA9421422	113	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA9421421 rs764122431	114	C>S		No	ClinGen ExAC gnomAD
CA9421420 rs763143581	115	M>I		No	ExAC gnomAD ClinGen
CA405727144 rs1295202411	115	M>L		No	gnomAD ClinGen
CA405727127 rs1600092383	117	D>A		No	Ensembl ClinGen
rs775751570 CA9421419	117	D>E		No	ExAC TOPMed gnomAD ClinGen
CA9421418 rs765585924	120	H>R		No	ClinGen ExAC gnomAD
rs759829124 CA9421417	121	L>F		No	ClinGen ExAC gnomAD
rs367884896 CA9421414	127	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA405727064 rs201019662	128	S>N		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA9421413 rs201019662	128	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	129	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773646026 CA9421396	130	D>G		No	ExAC gnomAD ClinGen
CA405727039 rs761218583	130	D>N		No	ExAC TOPMed gnomAD ClinGen
CA9421397 rs761218583	130	D>Y		No	ExAC TOPMed gnomAD ClinGen
rs768272386 CA9421395	131	V>D		No	ClinGen ExAC
TCGA novel	132	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762484838 CA9421394	132	L>Q		No	ClinGen ExAC gnomAD
rs1462800189 CA405727019	134	R>G		No	gnomAD ClinGen
CA308149853 rs1034357371	135	T>A		No	ClinGen Ensembl
CA405727008 rs1244027269	135	T>I		No	ClinGen gnomAD
CA9421391 rs745536651	136	L>P		No	ExAC TOPMed gnomAD ClinGen
CA405726992 rs1262275125	138	L>F		No	gnomAD ClinGen
CA405726988 rs765995884	139	P>H		No	gnomAD ClinGen
CA308149849 rs765995884	139	P>L		No	gnomAD ClinGen
CA9421389 rs368954450	139	P>S		No	1000Genomes TOPMed gnomAD ClinGen
rs781020265 CA9421388	140	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1568387184 CA405726976	141	P>L		No	Ensembl ClinGen
TCGA novel	141	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1304180352 CA405726974	142	T>A		No	ClinGen gnomAD
CA405726968 rs148295876	143	L>V		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1339385770 CA405726964	144	G>R		No	ClinGen Ensembl
rs777621304 CA9421385	145	P>S		No	ExAC gnomAD ClinGen
CA9421384 rs369340366	146	R>K		No	ClinGen ESP ExAC gnomAD
rs752727795 CA9421383	147	D>V		No	ExAC gnomAD ClinGen
rs1291023179 CA405726930	149	H>Y		No	gnomAD ClinGen
CA405726919 rs1363769201	150	T>I		No	gnomAD ClinGen
CA9421381 rs755164424	151	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9421364 rs748127312	152	P>T		No	ExAC gnomAD ClinGen
rs1224560066 CA405726894	153	V>M		No	ClinGen gnomAD
CA9421361 rs367723236	155	I>M		No	ESP ExAC TOPMed gnomAD ClinGen
rs962923125 CA308149722	156	G>D		No	TOPMed gnomAD ClinGen
CA9421360 rs373549975	157	R>K		No	ClinGen ESP ExAC gnomAD
CA9421359 rs371557607	157	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs756371673 CA9421358	158	V>I		No	ClinGen ExAC gnomAD
rs912228498 CA308149713	164	G>E		No	ClinGen TOPMed gnomAD
rs762376384 CA9421355	166	V>A		No	ExAC gnomAD ClinGen
rs762376384 CA405726807	166	V>G		No	ExAC gnomAD ClinGen
CA308149709 rs376928975	166	V>L		No	ClinGen ESP
rs1327317526 CA405726803	167	L>P		No	ClinGen TOPMed
CA405726795 rs1568386847	168	S>F		No	Ensembl ClinGen
rs1568386839 CA405726793	169	I>V		No	Ensembl ClinGen
CA405726780 rs1245868500	171	N>D		No	gnomAD ClinGen
rs1398905168 CA405726775	171	N>K		No	ClinGen TOPMed gnomAD
CA405726771 rs1221154134	172	Q>*		No	gnomAD ClinGen
rs374371333 CA308149702	172	Q>H		No	ClinGen ESP TOPMed gnomAD
rs866790293 CA308149699	174	Y>H		No	Ensembl ClinGen
rs533932628 CA9421354	175	L>Q		No	1000Genomes ExAC gnomAD ClinGen
rs1480705294 CA405726743	176	E>D		No	ClinGen gnomAD
rs764836843 CA9421353	176	E>K		No	ExAC TOPMed gnomAD ClinGen
rs1268156242 CA405726741	177	T>A		No	ClinGen gnomAD
rs1196119295 CA405726711	181	W>*		No	gnomAD ClinGen
CA405726706 rs147307947	182	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs147307947 CA9421352	182	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	183	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405726701 rs1600091413	183	R>G		No	Ensembl ClinGen
rs200576310 CA405726694	184	E>*		No	ClinGen ExAC TOPMed gnomAD
rs200576310 CA9421351	184	E>Q		No	ExAC TOPMed gnomAD ClinGen
rs1568386749 CA405726685	185	Q>*		No	Ensembl ClinGen
CA405726681 rs1315705238	185	Q>H		No	gnomAD ClinGen
rs765903998 CA9421350	186	T>A		No	ExAC gnomAD ClinGen
rs375961991 CA308149694	187	P>A		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA9421347 rs551357680	187	P>L		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs375961991 CA9421348	187	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA405726669 rs1434954796	188	Q>*		No	gnomAD ClinGen
CA405726670 rs1434954796	188	Q>E		No	ClinGen gnomAD
CA9421346 rs376088775	189	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA405726649 rs1260457360	191	E>Q		No	ClinGen TOPMed
CA405726642 rs199783744	192	P>A		No	TOPMed gnomAD ClinGen
CA308149676 rs199783744	192	P>S		No	TOPMed gnomAD ClinGen
rs199783744 CA308149679	192	P>T		No	TOPMed gnomAD ClinGen
CA9421344 rs768640400	194	A>T		No	ExAC gnomAD ClinGen
rs1600091316 CA405726626	194	A>V		No	Ensembl ClinGen
rs1000744889 CA308149666	196	Q>L		No	ClinGen TOPMed gnomAD
rs879882566 CA308149663	197	R>K		No	Ensembl ClinGen
rs149631177 CA308149658	198	H>L		No	ESP ExAC TOPMed gnomAD ClinGen
CA9421342 rs138338251	198	H>Q		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs149631177 CA9421343	198	H>R		No	ESP ExAC TOPMed gnomAD ClinGen
CA9421340 rs746131058	199	D>H		No	ClinGen ExAC TOPMed gnomAD
rs1232904166 CA405726593	200	P>A		No	ClinGen gnomAD
CA308149598 rs1038510682	204	N>S		No	TOPMed ClinGen
CA405726554 rs1038510682	204	N>T		No	TOPMed ClinGen
rs1297572363 CA405726548	205	P>S		No	ClinGen gnomAD
CA405726541 rs952042274	206	A>E		No	Ensembl ClinGen
CA308149597 rs952042274	206	A>V		No	ClinGen Ensembl
CA9421313 rs370738324	208	H>Y		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA9421311 rs201437690 CA9421310	209	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9421309 rs201437690	209	G>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA405726507 rs1352608507	212	W>S		No	ClinGen TOPMed
CA9421308 rs763988079	215	G>C		No	ExAC TOPMed gnomAD ClinGen
CA9421307 rs763988079	215	G>S		No	ClinGen ExAC TOPMed gnomAD
rs150811577 CA9421306	216	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1193499814 CA405726466	218	S>R		No	TOPMed gnomAD ClinGen
rs34570303 CA405726461	219	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9421304 rs34570303	219	P>R		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA405726465 rs1487605433	219	P>S		No	ClinGen gnomAD
CA9421302 rs776874731	220	E>*		No	ExAC gnomAD ClinGen
rs771242147 CA9421301	220	E>V		No	ClinGen ExAC gnomAD
CA308149578 rs35730797	221	V>A		No	ClinGen Ensembl
TCGA novel	221	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405726445 rs1216102275	222	D>G		No	TOPMed gnomAD ClinGen
CA9421299 rs777980220	226	P>L		No	ClinGen ExAC TOPMed gnomAD
CA308149560 rs748596055	227	A>S		No	ClinGen ExAC TOPMed gnomAD
CA9421297 rs748596055	227	A>T		No	ClinGen ExAC TOPMed gnomAD
rs890841367 CA308149558	227	A>V		No	ClinGen TOPMed
CA405726407 rs1457025331	229	A>T		No	gnomAD ClinGen
CA405726402 rs1347756566	229	A>V		No	ClinGen gnomAD
rs749507941 CA9421296	230	S>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	234	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs755485365 CA9421295	235	E>G		No	ClinGen ExAC gnomAD
CA405726368 rs1041411574	235	E>K		No	TOPMed ClinGen
rs1041411574 CA308149556	235	E>Q		No	TOPMed ClinGen
rs749883285 CA9421294	236	E>K		No	ExAC gnomAD ClinGen
rs1170446154 CA405726351	237	E>A		No	ClinGen gnomAD
rs578227113 CA9421293	238	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	239	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9421291 rs751271925	240	E>G		No	ExAC TOPMed gnomAD ClinGen
CA9421292 rs756872598	240	E>K		No	ClinGen ExAC gnomAD
CA405726328 rs1488235282	241	G>R		No	ClinGen gnomAD
TCGA novel	242	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9421290 rs763782042	242	K>T		No	ClinGen ExAC gnomAD
TCGA novel	243	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9421289 rs762744479	243	E>V		No	ClinGen ExAC TOPMed gnomAD
rs1257158370 CA405726308	244	E>*		No	gnomAD ClinGen
CA405726302 rs1216623235	244	E>D		No	gnomAD ClinGen
CA405726293 rs1386149354	246	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs1386149354 CA405726291	246	R>M		No	ClinGen gnomAD
rs752450623 CA9421288	246	R>W		No	ExAC gnomAD ClinGen
CA9421287 rs62640393	248	D>E		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1375839381 CA405726273	249	D>N		No	ClinGen TOPMed
rs759578897 CA9421286	250	P>L		No	ExAC gnomAD ClinGen
rs1362084583 CA405726263	250	P>S		No	gnomAD ClinGen
CA9421285 rs544178228	251	E>A		No	1000Genomes ExAC gnomAD ClinGen
rs145427015 CA9421284	251	E>D		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1442430742 CA405726259	251	E>Q		No	ClinGen gnomAD
CA405726248 CA9421283 rs760797174	252	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1432076467 CA405726245	253	E>*		No	gnomAD ClinGen
CA9421282 rs377035423	256	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1423103996 CA405726204	257	D>E		No	TOPMed gnomAD ClinGen
CA9421281 rs772185419	257	D>Y		No	ExAC gnomAD ClinGen
CA405726183 rs1458366820	259	L>F		No	TOPMed gnomAD ClinGen
rs1196528194 CA405726172	260	T>P		No	gnomAD ClinGen
CA9421277 rs769108123	265	S>T		No	ClinGen ExAC gnomAD
CA405726090 rs1464496927	266	L>V		No	gnomAD ClinGen
rs780658663 CA9421275	267	V>D		No	ExAC TOPMed gnomAD ClinGen
CA9421274 rs756817515	270	R>Q		No	ExAC TOPMed gnomAD ClinGen
rs1308476353 CA405726050	270	R>W		No	ClinGen gnomAD
rs746507237 CA9421273	271	S>N		No	ExAC TOPMed gnomAD ClinGen
CA405725994 rs1168487340	274	V>A		No	ClinGen TOPMed
CA405725998 rs141313340 CA405725997	274	V>L		No	ESP TOPMed gnomAD ClinGen
CA308149524 rs141313340	274	V>M		No	ClinGen ESP TOPMed gnomAD
CA9421271 rs758010105	277	Q>K		No	ExAC gnomAD ClinGen
CA9421270 rs752498100	280	S>I		No	ClinGen ExAC gnomAD
CA9421269 rs765167795 CA405725925	280	S>R		No	ClinGen ExAC TOPMed gnomAD
CA405725910 rs1465953944	282	R>P		No	gnomAD ClinGen
rs1600090540 CA405725897	283	V>G		No	ClinGen Ensembl
rs1186942418 CA405725905	283	V>M		No	gnomAD ClinGen
CA405725887 rs1448500025	284	R>L		No	ClinGen TOPMed
rs1600090536 CA405725895	284	R>S		No	Ensembl ClinGen
rs1161363036 CA405725879	285	I>T		No	TOPMed gnomAD ClinGen
CA405725872 rs1379774051	286	A>T		No	ClinGen gnomAD
CA9421267 rs201138591	286	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs766566003 CA9421266	289	S>F		No	ExAC gnomAD ClinGen
CA405725804 rs1278330337	291	G>C		No	ClinGen TOPMed
CA405725802 rs143140525	291	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA405725806 rs1278330337	291	G>R		No	ClinGen TOPMed
CA9421265 rs143140525	291	G>V		No	ESP ExAC TOPMed gnomAD ClinGen
rs572929934 CA9421264	292	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1352250773 CA405725763	294	G>E		No	gnomAD ClinGen
CA405725759 rs1600090462	295	S>A		No	Ensembl ClinGen
CA405725754 rs1306470671	295	S>C		No	ClinGen TOPMed gnomAD
CA405725756 rs1306470671	295	S>Y		No	ClinGen TOPMed gnomAD
CA9421262 rs767726293	297	D>A		No	ExAC gnomAD ClinGen
CA405725735 rs1212686000	297	D>N		No	ClinGen TOPMed
rs1400687254 CA405725708	299	A>D		No	ClinGen gnomAD
rs761969069 CA9421261	299	A>T		No	ClinGen ExAC TOPMed gnomAD
CA405725702 rs1188414373	300	T>M		No	ClinGen gnomAD
CA9421260 rs774666021	301	E>Q		No	ExAC gnomAD ClinGen
CA308149505 rs757654881	305	D>E		No	Ensembl ClinGen
rs1194621936 CA405725671	305	D>G		No	ClinGen TOPMed
CA9421259 rs769057247	306	V>M		No	ExAC gnomAD ClinGen
rs776042137 CA405725661	307	R>P		No	ClinGen ExAC gnomAD
CA9421257 rs776042137	307	R>Q		No	ClinGen ExAC gnomAD
CA405725662 rs749779818	307	R>W		No	ExAC TOPMed gnomAD ClinGen
rs770300441 CA9421256	309	L>F		No	ClinGen ExAC gnomAD
CA9421254 rs149104673	311	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149104673 CA405725637	311	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9421255 rs746481512	311	T>P		No	ExAC gnomAD ClinGen
rs1421900438 CA405725636	312	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	gnomAD ClinGen NCI-TCGA
rs1263589115 CA405725631	312	D>V		No	gnomAD ClinGen
rs1212192098 CA405725626	313	L>F		No	ClinGen gnomAD
rs952072084 CA308149499	315	D>Y		No	ClinGen gnomAD
rs747808605 CA9421252	316	H>R		No	ClinGen ExAC gnomAD
rs758039339 CA9421253	316	H>Y		No	ClinGen ExAC gnomAD
CA9421251 rs539343419	318	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs753693460 CA9421249	321	S>A		No	ExAC gnomAD ClinGen
TCGA novel	321	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405725546 rs1339019311	325	A>S		No	ClinGen gnomAD
CA405725548 rs1339019311	325	A>T		No	gnomAD ClinGen
rs1350537227 CA405725536	327	F>L		No	ClinGen TOPMed gnomAD
rs1178037223 CA405725524	328	G>A		No	TOPMed ClinGen
rs1357189180 CA405725521	329	S>G		No	ClinGen TOPMed
rs766358453 CA9421248	331	G>D		No	ExAC TOPMed gnomAD ClinGen
rs758187756 CA9421246	332	P>R		No	ExAC gnomAD ClinGen
rs752382508 CA308149487	335	P>S		No	ClinGen ExAC TOPMed gnomAD
CA9421245 rs752382508	335	P>T		No	ExAC TOPMed gnomAD ClinGen
rs1162819173 CA405725466	337	K>N		No	gnomAD ClinGen
CA405725457 rs1221418226	339	E>K		No	ClinGen TOPMed
CA9421240 rs764435717	339	E>V		No	ClinGen ExAC gnomAD
CA9421239 rs763246999	340	D>V		No	ExAC TOPMed gnomAD ClinGen
rs145095885 CA9421238	341	P>S		No	ESP ExAC TOPMed gnomAD ClinGen
rs770295375 CA9421237	342	G>R		No	ClinGen ExAC TOPMed gnomAD
rs770295375 CA405725438	342	G>S		No	ExAC TOPMed gnomAD ClinGen
rs750375894 CA9421225	343	P>T		No	ClinGen ExAC gnomAD
rs1456296470 CA405725107	346	E>*		No	ClinGen TOPMed
rs1180757916 CA405725106	346	E>G		No	ClinGen TOPMed
rs1456296470 CA405725109	346	E>K		No	ClinGen TOPMed
CA405725096 rs1238467935	347	T>M		No	gnomAD ClinGen
rs1199654845 CA405725078	350	C>F		No	ClinGen gnomAD
rs1256574565 CA405725073	351	Q>K		No	ClinGen TOPMed gnomAD
rs113813704 CA308149395	352	A>T		No	ClinGen Ensembl
rs1416493716 CA405725048	355	A>T		No	TOPMed ClinGen
rs753531642 CA308149392	360	A>T		No	TOPMed gnomAD ClinGen
rs1173493889 CA405724925	362	W>L		No	TOPMed ClinGen
CA405724911 rs1555730738	363	T>A		No	ClinGen Ensembl
rs943020608 CA308149390	363	T>I		No	ClinGen TOPMed
CA9421224 rs781318149	364	R>P		No	ClinGen ExAC gnomAD
rs987119206 CA308149388	368	L>H		No	Ensembl ClinGen
rs757345688 CA9421223	369	R>*		No	ClinGen ExAC gnomAD
rs1310177375 CA405724782	369	R>L		No	gnomAD ClinGen
CA308149383 rs373342358	371	P>L		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs373342358 CA9421222	371	P>R		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1172758815 CA405724757	371	P>T		No	TOPMed gnomAD ClinGen
CA9421221 rs764253612 COSM4140615	372	E>D	ovary [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
rs1335975683 CA405724711	372	E>G		No	gnomAD ClinGen
CA308149380 rs946423928	372	E>K		No	ClinGen TOPMed gnomAD
CA308149377 rs1020115538	373	L>R		No	Ensembl ClinGen
rs1010002509 CA308149376	374	R>Q		No	ClinGen TOPMed gnomAD
CA405724620 rs1170279832	377	R>W		No	ClinGen gnomAD
rs1195078728 CA405724563	379	R>P		No	TOPMed ClinGen
rs1236688897 CA405724463	383	L>P		No	ClinGen gnomAD
rs112991515 CA308149370	384	R>G		No	TOPMed gnomAD ClinGen
rs527823007 CA9421217	384	R>Q		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA405724420 rs1486903180	385	A>E		No	TOPMed gnomAD ClinGen
CA405724405 rs1422109035	386	G>A		No	ClinGen TOPMed
CA308149365 CA405724411 rs762866990	386	G>R		No	TOPMed gnomAD ClinGen
CA308149364 rs929243720	387	A>G		No	ClinGen Ensembl
CA308149361 rs929243720	387	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	Ensembl ClinGen NCI-TCGA
rs1046007265 CA308149358	389	P>L		No	Ensembl ClinGen
TCGA novel	390	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1375011491 CA405724341	391	G>V		No	gnomAD ClinGen
CA405724336 rs1401931386	392	A>T		No	TOPMed ClinGen
CA405724311 rs1448552339	393	Q>L		No	ClinGen gnomAD
CA405724302 CA405724301 rs1252744005	394	G>R		No	gnomAD ClinGen
CA405724277 rs1360550156	395	P>L		No	ClinGen gnomAD
CA405724284 rs1421452551	395	P>T		No	ClinGen gnomAD
rs1417445576 CA405724269	396	G>E		No	ClinGen gnomAD
CA308149341 rs886623702	397	P>R		No	ClinGen TOPMed gnomAD
CA405724258 rs1242134014	397	P>S		No	gnomAD ClinGen
CA9421212 rs768380664	398	E>K		No	ClinGen ExAC TOPMed gnomAD
CA308149338 rs768380664	398	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA9421211 rs551994146	399	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA308149335 rs867530671	399	G>K		No	ClinGen Ensembl
rs769534424 CA9421209	400	Q>H		No	ExAC ClinGen
rs779874200 CA9421210	400	Q>K		No	ExAC TOPMed ClinGen
CA9421208 rs745813323	402	P>A		No	ExAC gnomAD ClinGen
CA9421207 rs8110393 VAR_038926	402	P>L		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA405724134 rs8110393	402	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs376584524 CA9421206	403	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs751598945 CA9421205	403	A>V		No	ClinGen ExAC gnomAD
rs777872922 CA9421204	404	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA405724040 rs1039521721	407	R>W		No	ClinGen TOPMed gnomAD
CA308149320 rs1039950566	409	R>G		No	TOPMed gnomAD ClinGen
rs752978765 CA9421202	409	R>H		No	ClinGen ExAC TOPMed gnomAD
rs752978765 CA405723976	409	R>L		No	ExAC TOPMed gnomAD ClinGen
rs1039950566 CA405723987	409	R>S		No	TOPMed gnomAD ClinGen
rs563133966 CA9421201	410	I>V		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA9421199 rs754247587	411	H>L		No	ClinGen ExAC gnomAD
CA308149310 rs911862293	411	H>Q		No	ClinGen TOPMed gnomAD
CA308149306 rs986763414	412	E>*		No	ClinGen TOPMed gnomAD
CA405723911 rs986763414	412	E>K		No	TOPMed gnomAD ClinGen
CA308149308 rs986763414	412	E>Q		No	TOPMed gnomAD ClinGen
CA405723868 rs1163278858	413	R>C		No	TOPMed gnomAD ClinGen
rs955244610 CA308149305	413	R>H		No	TOPMed gnomAD ClinGen
CA405723874 rs1163278858	413	R>S		No	ClinGen TOPMed gnomAD
CA405723846 rs1264608949	414	L>F		No	ClinGen gnomAD
rs1193031998 CA405723833	415	A>T		No	gnomAD ClinGen
CA405723788 rs1487308697	416	H>Q		No	gnomAD ClinGen
rs1248539378 CA405723744	418	H>Q		No	ClinGen TOPMed gnomAD
rs766744570 CA9421198	419	A>P		No	ExAC gnomAD ClinGen
rs1302403172 CA405723708	420	A>T		No	ClinGen TOPMed
CA405723686 rs1220290323	421	C>R		No	ClinGen gnomAD
CA405723628 rs1277412793	423	P>L		No	ClinGen TOPMed gnomAD
CA405723616 rs1241836202	424	R>C		No	ClinGen TOPMed
CA308149291 rs988601854	424	R>L		No	Ensembl ClinGen
CA9421195 rs768327473	425	R>L		No	ClinGen ExAC TOPMed gnomAD
rs768327473 CA405723589	425	R>P		No	ExAC TOPMed gnomAD ClinGen
rs762680246 CA405723560	426	K>N		No	ExAC gnomAD ClinGen
rs1293640615 CA405723531	427	V>A		No	gnomAD ClinGen
rs1435276402 CA405723481	430	L>F		No	ClinGen gnomAD
CA9421193 rs775069678	430	L>P		No	ExAC TOPMed gnomAD ClinGen
CA308149282 rs868144289	432	E>D		No	Ensembl ClinGen
rs769491150 CA9421192	433	V>L		No	ExAC gnomAD ClinGen
rs769491150 CA308149280	433	V>M		No	ExAC gnomAD ClinGen
rs1170512688 CA405723291	436	D>G		No	gnomAD ClinGen
CA405723272 rs1427279156	437	V>I		No	ClinGen gnomAD
rs770823837 CA9421189	438	Y>*		No	ExAC gnomAD ClinGen
CA405723234 rs1488264934	438	Y>C		No	gnomAD ClinGen
CA405723246 rs1191886234	438	Y>H		No	gnomAD ClinGen
CA405723236 rs1488264934	438	Y>S		No	gnomAD ClinGen
rs758543281 CA9421187	439	A>E		No	ExAC gnomAD ClinGen
CA9421186 rs758543281	439	A>G		No	ExAC gnomAD ClinGen
CA9421188 rs747000564	439	A>S		No	ClinGen ExAC gnomAD
CA405723187 rs1196635677	440	G>S		No	ClinGen gnomAD
rs778949362 CA9421184	441	L>V		No	ClinGen ExAC gnomAD
rs755254038 CA9421183	443	R>*		No	ClinGen ExAC TOPMed gnomAD
rs755254038 CA405723115	443	R>G		No	ClinGen ExAC TOPMed gnomAD
CA405723108 rs113728915	443	R>P		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
CA9421182 rs113728915	443	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD ClinGen
rs1310907005 CA405723083	444	G>D		No	ClinGen gnomAD
CA308149264 rs939160689	444	G>S		No	ClinGen TOPMed
rs766802528 CA405723074	445	E>*		No	ExAC TOPMed gnomAD ClinGen
CA9421181 rs766802528	445	E>K		No	ExAC TOPMed gnomAD ClinGen
rs764405811 CA9421164	448	D>G		No	ClinGen ExAC TOPMed gnomAD
CA405723001 rs1331132504	448	D>H		No	ClinGen TOPMed gnomAD
CA405723005 rs1331132504	448	D>N		No	ClinGen TOPMed gnomAD
CA9421163 rs756612255	449	P>S		No	ExAC gnomAD ClinGen
CA405722906 rs756612255	449	P>T		No	ClinGen ExAC gnomAD
CA9421162 rs750820451	450	L>P		No	ExAC ClinGen
rs757804252 CA9421160	454	A>V		No	ExAC TOPMed gnomAD ClinGen
rs1353677264 CA405722790	455	F>C		No	TOPMed ClinGen
CA405722769 rs1352508228	457	P>A		No	gnomAD ClinGen
CA405722762 rs1258659685	457	P>L		No	gnomAD ClinGen
rs147778742 CA9421159	459	L>P		No	ClinGen ESP ExAC gnomAD
rs1463117146 CA405722718	461	E>K		No	ClinGen TOPMed gnomAD
rs1463117146 CA405722716	461	E>Q		No	ClinGen TOPMed gnomAD
rs764851936 CA9421158	463	L>F		No	ClinGen ExAC gnomAD
CA308149183 rs935857038	463	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs553881151 CA308149180	464	I>F		No	ExAC gnomAD ClinGen
rs553881151 CA9421157	464	I>V		No	ExAC gnomAD ClinGen
CA9421156 rs769865743	467	P>L		No	ClinGen ExAC gnomAD
rs1400763441 CA405722589	468	D>E		No	gnomAD ClinGen
rs925767867 CA308149175	468	D>Y		No	ClinGen gnomAD
CA405722574 rs547809211	469	I>S		No	ExAC TOPMed gnomAD ClinGen
CA9421154 rs547809211	469	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1413632456 CA405722582	469	I>V		No	TOPMed ClinGen
rs1213297622 CA405722538	471	D>E		No	TOPMed ClinGen
CA9421152 rs771961902	472	T>A		No	ExAC gnomAD ClinGen
TCGA novel	474	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405722431 rs1600088579	483	L>F		No	ClinGen Ensembl
rs1427149776 CA405722418	485	P>R		No	Ensembl ClinGen
rs774269200 CA9421150	485	P>T		No	ClinGen ExAC gnomAD
rs749463854 CA405722394	489	R>G		No	ClinGen ExAC gnomAD
CA405722391 rs1365927213	489	R>L		No	ClinGen TOPMed gnomAD
TCGA novel	489	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9421145 rs771470330	491	E>D		No	ClinGen ExAC gnomAD
CA405722318 rs1317017163	492	A>V		No	TOPMed ClinGen
rs1351035078 CA405722290	494	Y>C		No	TOPMed ClinGen
rs778287881 CA9421121	495	Y>C		No	ExAC ClinGen
rs1254163965 CA405722246	496	L>P		No	ClinGen TOPMed gnomAD
CA405722233 rs1302866457	497	T>N		No	gnomAD ClinGen
CA405722213 rs1324345743	498	T>M		No	TOPMed ClinGen
CA9421120 rs758854340	500	F>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	502	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1402139827 CA405722156	502	A>T		No	ClinGen gnomAD
rs753310016 CA9421119	504	H>Y		No	ClinGen ExAC gnomAD
rs1173818428 CA405722059	507	A>S		No	TOPMed gnomAD ClinGen
rs1173818428 CA405722061	507	A>T		No	TOPMed gnomAD ClinGen
rs779582845 CA9421118	507	A>V		No	ClinGen ExAC gnomAD
rs755738268 CA9421116	510	Q>E		No	ClinGen ExAC gnomAD
rs750129340 CA9421115	511	P>L		No	ClinGen ExAC gnomAD
CA308149119 rs892466769	514	D>E		No	TOPMed ClinGen
TCGA novel	514	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	515	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9421113 rs561658803	515	R>G		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs528085067 CA405721996	516	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs528085067 CA9421111	516	A>S		No	1000Genomes ExAC TOPMed gnomAD ClinGen
rs528085067 CA9421110	516	A>T		No	1000Genomes ExAC TOPMed gnomAD ClinGen
CA405721995 rs1443316320	516	A>V		No	gnomAD ClinGen
rs374497752 CA9421108	518	R>P		No	ESP ExAC gnomAD ClinGen
rs374497752 CA405721985	518	R>Q		No	ESP ExAC gnomAD ClinGen
CA9421109 rs775679788	518	R>W		No	ClinGen ExAC gnomAD
rs925829070 CA308149115	519	G>A		No	Ensembl ClinGen
rs1468271417 CA405721936	522	S>A		No	ClinGen TOPMed
CA405721914 rs1186199061	523	E>*		No	Ensembl ClinGen
CA405721872 rs1568384821	525	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA405721874 rs1568384821	525	R>G		No	ClinGen Ensembl
CA405721863 rs1441299731	526	A>T		No	gnomAD ClinGen
CA308149107 rs200476957	529	H>Q		No	Ensembl ClinGen
CA9421102 rs140416410	529	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA405721776 rs1374284241	530	Q>H		No	gnomAD ClinGen
CA405721782 rs1163435007	530	Q>R		No	ClinGen TOPMed
CA9421100 rs772604618	533	R>G		No	ExAC TOPMed gnomAD ClinGen
rs753675607 CA9421099	533	R>H		No	ClinGen ExAC gnomAD
CA9421098 rs753675607	533	R>L		No	ClinGen ExAC gnomAD
rs755685223 CA9421097	534	R>K		No	ClinGen ExAC
TCGA novel	534	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405721691 rs1159623296	535	R>L		No	gnomAD ClinGen
rs1159623296 CA405721695	535	R>Q		No	gnomAD ClinGen
rs1466478403 CA405721700	535	R>W		No	TOPMed ClinGen
rs1443529463 CA405721641	538	H>Q		No	ClinGen gnomAD
CA405721648 rs1600087983	538	H>R		No	ClinGen Ensembl
rs780838033 CA9421095	538	H>Y		No	ExAC TOPMed gnomAD ClinGen
CA9421094 rs756880578	539	R>G		No	ClinGen ExAC TOPMed gnomAD
rs751328829 CA9421092	541	D>V		No	ClinGen ExAC gnomAD
CA405721585 rs1357482557	543	P>T		No	TOPMed ClinGen
CA405721553 rs1476411285	544	R>S		No	Ensembl ClinGen
rs147291135 CA405721440	547	A>S		No	ClinGen ESP ExAC TOPMed
CA9421079 rs147291135	547	A>T		No	ESP ExAC TOPMed ClinGen
rs745332133 CA9421078	548	N>S		No	ExAC gnomAD ClinGen
CA405721390 rs1377439533	550	P>T		No	ClinGen TOPMed
CA405721324 rs1413014430	554	P>A		No	ClinGen TOPMed
rs1340545763 CA405721313	555	W>*		No	gnomAD ClinGen
COSM3692735 rs756901954 CA9421076	555	W>R	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA405721302 rs1269111485	557	E>*		No	gnomAD ClinGen
CA405721291 rs1351317812	558	E>D		No	ClinGen gnomAD
CA308149072 rs768985748	558	E>K		No	ClinGen TOPMed gnomAD
rs746689126 CA9421075	562	G>E		No	ClinGen ExAC gnomAD
CA405721264 rs1462232351	563	T>S		No	gnomAD ClinGen
rs758201815 CA9421073	564	S>N		No	ClinGen ExAC TOPMed gnomAD
CA405721240 rs1163340338	566	N>I		No	ClinGen gnomAD
rs890620294 CA308149063	567	N>Y		No	ClinGen TOPMed

No associated diseases with Q6ZS11

No regional properties for Q6ZS11

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q6ZS11

Functions

		Description
EC Number
Subcellular Localization	Cell projection, ruffle Cytoplasmic vesicle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endocytic vesicle	A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
ruffle	Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

3 GO annotations of molecular function

Name	Definition
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
small GTPase binding	Binding to a small monomeric GTPase.

2 GO annotations of biological process

Name	Definition
endocytosis	A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P54787	VPS9	Vacuolar protein sorting-associated protein 9	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR

10	20	30	40	50	60
MAQPEDKAPE	VPTEGVRLVP	PQVNKADRTP	LGVLSTLEPL	TRLQRTWGVW	HVPELDTQDA
70	80	90	100	110	120
EALVGLWPLG	SFLVTGRDPS	QALVLRSGPL	PGEVNTYQIQ	KIPRGVSLES	SNLCMPDLPH
130	140	150	160	170	180
LLAFLSASRD	VLPRTLLLPP	PTLGPRDEHT	DPVQIGRVQQ	DTPGKVLSIV	NQLYLETHRG
190	200	210	220	230	240
WGREQTPQET	EPEAAQRHDP	APRNPAPHGV	SWVKGPLSPE	VDHPGPALAS	LLEEEEEDLE
250	260	270	280	290	300
GKEEGREDDP	EEEGPEDVLT	IHVQSLVRAR	SSYVARQYRS	LRVRIASDSG	GPHGSGDPAT
310	320	330	340	350	360
ELLQDVRHLL	TDLQDHLAKD	SYIRAVFGSR	GPGLPKKDED	PGPALETAVC	QAVLAPLKPA
370	380	390	400	410	420
LWTRLRTLRA	PELRRLRRRQ	TALRAGAGPP	GAQGPGPEGQ	SPAPALRSRI	HERLAHLHAA
430	440	450	460	470	480
CAPRRKVALL	LEVCRDVYAG	LARGENQDPL	GADAFLPALT	EELIWSPDIG	DTQLDVEFLM
490	500	510	520	530	540
ELLDPDELRG	EAGYYLTTWF	GALHHIAHYQ	PETDRAPRGL	SSEARASLHQ	WHRRRTLHRK
550	560
DHPRAQANLP	FKEPWAEETV	TGTSDN