P54787
Gene name |
VPS9 (VPT9, YML097C) |
Protein name |
Vacuolar protein sorting-associated protein 9 |
Names |
Vacuolar protein-targeting protein 9 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YML097C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P54787
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1MN3 | X-ray | 230 A | A | 398-451 | PDB |
| 1P3Q | X-ray | 170 A | Q/R | 398-451 | PDB |
| AF-P54787-F1 | Predicted | AlphaFoldDB |
15 variants for P54787
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-79582 | 37 | P>S | No | SGRP | |
| s13-79575 | 39 | R>K | No | SGRP | |
| s13-79558 | 45 | T>P | No | SGRP | |
| s13-79375 | 106 | S>G | No | SGRP | |
| s13-79364 | 109 | K>N | No | SGRP | |
| s13-79341 | 117 | T>I | No | SGRP | |
| s13-79323 | 123 | R>Q | No | SGRP | |
| s13-78777 | 305 | N>S | No | SGRP | |
| s13-78749 | 314 | E>D | No | SGRP | |
| s13-78726 | 322 | A>E | No | SGRP | |
| s13-78710 | 327 | F>L | No | SGRP | |
| s13-78669 | 341 | K>R | No | SGRP | |
| s13-78658 | 345 | I>V | No | SGRP | |
| s13-78550 | 381 | T>A | No | SGRP | |
| s13-78538 | 385 | A>T | No | SGRP |
No associated diseases with P54787
1 regional properties for P54787
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Ribosomal protein L31e, conserved site | 55 - 69 | IPR020052 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| endocytic vesicle | A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| small GTPase binding | Binding to a small monomeric GTPase. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| Golgi to endosome transport | The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. |
| late endosome to vacuole transport via multivesicular body sorting pathway | The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole. |
| protein localization to endosome | A process in which a protein is transported to, or maintained in, a location within an endosome. |
| protein targeting to vacuole | The process of directing proteins towards the vacuole, usually using signals contained within the protein. |
| vacuole inheritance | The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6ZS11 | RINL | Ras and Rab interactor-like protein | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTDDEKREIL | KEFDPFSQLE | QANGNPDKDV | KFKKDDPNRA | AAEETNRDIS | AQDKGDEEPF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YDFQIFIKQL | QTPGADPLVK | YTKSFLRNFL | AQRLLWTVSE | EIKLISDFKT | FIYDKFTLYE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PFRSLDNSKM | RNAKEGMEKL | IMGKLYSRCF | SPSLYEILQK | PLDDEHMKDL | TNDDTLLEKI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RHYRFISPIM | LDIPDTMPNA | RLNKFVHLAS | KELGKINRFK | SPRDKMVCVL | NASKVIFGLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KHTKLEQNGA | DSFIPVLIYC | ILKGQVRYLV | SNVNYIERFR | SPDFIRGEEE | YYLSSLQAAL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NFIMNLTERS | LTIEDHEDFE | EAYQRNFKQL | AEEKEEEEKK | KQLEIPDELQ | PNGTLLKPLD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EVTNIVISKF | NELFSPIGEP | TQEEALKSEQ | SNKEEDVSSL | IKKIEENERK | DTLNTLQNMF |
| 430 | 440 | 450 | |||
| PDMDPSLIED | VCIAKKSRIG | PCVDALLSLS | E |