AiPD: Autoinhibited Protein Database

Q6ZRY4

Gene name	RBPMS2
Protein name	RNA-binding protein with multiple splicing 2
Names	RNA binding protein, mRNA processing factor 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:348093
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-56 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q6ZRY4

Entry ID	Method	Resolution	Chain	Position	Source
2M9K	NMR	-	A/B	27-117	PDB
AF-Q6ZRY4-F1	Predicted				AlphaFoldDB

184 variants for Q6ZRY4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA7611113 rs758862192	2	S>N		No	ClinGen ExAC gnomAD
CA392835829 rs1165959512	3	N>S		No	ClinGen gnomAD
CA392835808 rs1476165438	5	K>E		No	ClinGen TOPMed gnomAD
CA392835796 rs1445004109	5	K>N		No	ClinGen TOPMed
CA271454161 rs950662583	6	P>S		No	ClinGen TOPMed
rs1242303758 CA392835776	7	D>G		No	ClinGen gnomAD
rs1182648897 CA392835763	8	G>C		No	ClinGen gnomAD
rs1595798841 CA392835759	8	G>D		No	ClinGen Ensembl
rs1372735944 CA392835747	9	E>G		No	ClinGen TOPMed
TCGA novel	9	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1317489661 CA392835727	10	H>Q		No	ClinGen TOPMed
rs1444614895 CA392835734	10	H>Y		No	ClinGen TOPMed
rs1459582251 CA392835718	11	G>D		No	ClinGen TOPMed gnomAD
rs1360434914 CA392835722	11	G>R		No	ClinGen TOPMed
CA7611112 rs753419459	12	G>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1206049711 CA392835696	13	S>G		No	ClinGen gnomAD
CA392835677 rs1308987488	14	T>S		No	ClinGen TOPMed
rs777493863 CA392835675	15	G>C		No	ClinGen ExAC gnomAD
rs777493863 CA7611111	15	G>R		No	ClinGen ExAC gnomAD
rs1341971766 CA392835663	17	G>S		No	ClinGen gnomAD
CA392835655 rs1298595322	18	S>Y		No	ClinGen gnomAD
rs1184893347 CA392835642	20	A>G		No	ClinGen TOPMed
CA392835644 rs1380593560	20	A>T		No	ClinGen gnomAD
rs1184893347 CA392835641	20	A>V		No	ClinGen TOPMed
CA392835635 rs1453221789	21	G>D		No	ClinGen gnomAD
rs1161033072 CA392835625	23	G>D		No	ClinGen TOPMed
rs1326815098 CA392835613	25	A>D		No	ClinGen gnomAD
CA7611030 rs763267659	31	R>W		No	ClinGen ExAC gnomAD
rs372396252 CA271432144	36	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1247676986 CA392832680	40	V>G		No	ClinGen TOPMed
CA392832690 rs1414052266	40	V>M		No	ClinGen gnomAD
rs1200481396 CA392832589	47	L>I		No	ClinGen TOPMed gnomAD
CA392832569 rs1472951785	48	Y>C		No	ClinGen TOPMed
rs867078048 CA271432112	51	F>C		No	ClinGen gnomAD
rs575548719 CA7611016	52	R>P		No	ClinGen 1000Genomes ExAC gnomAD
rs575548719 CA7611017	52	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA7611018 rs150042844	52	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA392832511 rs1434111677	53	P>S		No	ClinGen TOPMed
rs1317952764 CA392832482	55	K>E		No	ClinGen gnomAD
CA392832322 rs1285883341	58	E>G		No	ClinGen gnomAD
rs773219707 CA7610984	63	K>T		No	ClinGen ExAC gnomAD
CA7610983 rs769653515	64	L>F		No	ClinGen ExAC gnomAD
CA7610981 rs768536420	66	A>E		No	ClinGen ExAC gnomAD
rs768136796 CA7610982	66	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7610980 rs768536420	66	A>V		No	ClinGen ExAC gnomAD
CA392832217 rs1163168657	67	R>K		No	ClinGen TOPMed
CA392831601 rs1222355232	70	V>F		No	ClinGen TOPMed gnomAD
CA392831605 rs1222355232	70	V>I		No	ClinGen TOPMed gnomAD
rs373158060 CA271429818	76	D>E		No	ClinGen ESP TOPMed gnomAD
rs749741830 CA7610951	78	R>H		No	ClinGen ExAC gnomAD
rs1400806459 CA392831480	79	A>G		No	ClinGen TOPMed gnomAD
CA7610950 rs778355375	79	A>S		No	ClinGen ExAC gnomAD
CA7610949 rs756365664	80	G>R		No	ClinGen ExAC gnomAD
rs201860883 CA271429801	81	A>V		No	ClinGen 1000Genomes
COSM3386978 rs371776849 CA7610948	83	A>V	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1369249003 CA392831414	85	K>R		No	ClinGen TOPMed gnomAD
CA392831415 rs1369249003	85	K>T		No	ClinGen TOPMed gnomAD
CA392831399 rs1293805585	86	N>S		No	ClinGen gnomAD
CA392831385 rs1429400493	87	A>E		No	ClinGen TOPMed gnomAD
rs1429400493 CA392831381	87	A>V		No	ClinGen TOPMed gnomAD
rs1198077756 CA392831376	88	L>V		No	ClinGen TOPMed
rs750140091	89	N>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1283931795 CA392831294	90	G>D		No	ClinGen gnomAD
rs1285588603 CA392831286	91	I>V		No	ClinGen TOPMed
CA7610920 COSM963970 rs752694645	92	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1567064390 CA392831238	94	D>V		No	ClinGen Ensembl
rs748590604 CA271429370	95	P>S		No	ClinGen Ensembl
rs748590604 CA271429377	95	P>T		No	ClinGen Ensembl
COSM193774 rs774369247 CA7610917	96	E>K	large_intestine Variant assessed as Somatic; 4.619e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA392831186 rs1484071523	98	P>S		No	ClinGen gnomAD
CA7610916 rs766653294	99	Q>E		No	ClinGen ExAC gnomAD
rs762894837 CA7610915	100	T>A		No	ClinGen ExAC gnomAD
CA392831093 rs1228470227	105	F>L		No	ClinGen gnomAD
CA7610912 rs748660268	109	N>S		No	ClinGen ExAC
TCGA novel	111	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1025942217 CA271429297	111	K>R		No	ClinGen TOPMed gnomAD
rs367588995 CA271429262	113	A>S		No	ClinGen Ensembl
rs367588995 CA271429269	113	A>T		No	ClinGen Ensembl
CA7610911 rs777339070	115	S>R		No	ClinGen ExAC TOPMed gnomAD
CA392830942 rs1394807407	116	K>N		No	ClinGen TOPMed gnomAD
CA7610910 rs769087353	117	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1368921895 CA392830919	118	M>R		No	ClinGen gnomAD
CA7610908 rs564171937	118	M>V		No	ClinGen 1000Genomes ExAC gnomAD
CA271429199 rs139844024	120	T>A		No	ClinGen ESP
rs1430480401 CA392830889	120	T>I		No	ClinGen TOPMed gnomAD
CA7610906 rs375114329	122	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA392830875 rs375114329	122	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA392830852 rs1425505458	123	P>R		No	ClinGen gnomAD
CA7610905 rs777329163	123	P>T		No	ClinGen ExAC gnomAD
CA392830846 rs1256552996	124	S>N		No	ClinGen gnomAD
CA7610904 rs755679041	124	S>R		No	ClinGen ExAC TOPMed gnomAD
CA271429172 rs147479047	125	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA392830812 rs767445444	126	V>A		No	ClinGen ExAC TOPMed gnomAD
CA7610902 rs767445444	126	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1253511028 CA392830819	126	V>M		No	ClinGen gnomAD
COSM963969 rs145944256 CA7610901	129	A>T	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs377133037 CA7610899	130	L>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	131	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	133	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373694645 CA392830704	134	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA7610894 rs777214314	135	I>T		No	ClinGen ExAC gnomAD
rs762001990 CA7610895	135	I>V		No	ClinGen ExAC TOPMed gnomAD
CA271429110 rs188576967	136	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7610892 rs188576967	136	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA7610889 rs748952790	137	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM1223432 CA7610890 rs142321272	137	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs777416076 CA7610888	138	D>V		No	ClinGen ExAC gnomAD
rs1267277214 CA392830586	140	Y>C		No	ClinGen TOPMed
rs1450172948 CA392830574	141	D>Y		No	ClinGen TOPMed
rs1200635116 CA392830556	142	L>R		No	ClinGen gnomAD
CA392830538 rs1246893308	143	M>I		No	ClinGen gnomAD
rs772419094 CA7610873	143	M>V		No	ClinGen ExAC gnomAD
rs148067403 CA7610872	144	G>E		No	ClinGen ESP ExAC gnomAD
CA7610871 rs772809560	145	A>S		No	ClinGen ExAC TOPMed gnomAD
CA392830525 rs772809560	145	A>T		No	ClinGen ExAC TOPMed gnomAD
CA392830513 rs1421357944	146	A>S		No	ClinGen gnomAD
rs1270615571 CA392830505	146	A>V		No	ClinGen gnomAD
rs769457497 CA7610870	147	L>V		No	ClinGen ExAC gnomAD
CA392830478 rs1567064124	149	P>S		No	ClinGen Ensembl
CA392830468 rs1344826357	150	A>S		No	ClinGen TOPMed gnomAD
CA392830471 rs1344826357	150	A>T		No	ClinGen TOPMed gnomAD
CA392830462 rs1273297613	150	A>V		No	ClinGen gnomAD
rs967227188 CA271428759	151	S>P		No	ClinGen TOPMed
CA7610869 rs747849034	153	E>D		No	ClinGen ExAC gnomAD
CA392830404 rs1162525637	155	W>C		No	ClinGen TOPMed
CA7610867 rs111422187	155	W>G		No	ClinGen 1000Genomes ExAC gnomAD
CA271428749 rs111422187	155	W>R		No	ClinGen 1000Genomes ExAC gnomAD
rs78395952 CA7610866	156	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7610864 rs200454835	157	P>S		No	ClinGen 1000Genomes ExAC gnomAD
CA392830373 rs1595786139	158	Y>S		No	ClinGen Ensembl
CA392830364 rs1399801386	159	P>A		No	ClinGen gnomAD
rs779230678 CA7610862	162	T>A		No	ClinGen ExAC gnomAD
rs779230678 CA392830329	162	T>P		No	ClinGen ExAC gnomAD
rs1595786127 CA392830316	163	T>A		No	ClinGen Ensembl
rs757519713 CA7610861	164	E>G		No	ClinGen ExAC gnomAD
CA392830283 rs1595786123	166	T>P		No	ClinGen Ensembl
CA392830260 rs1331748424	168	A>T		No	ClinGen TOPMed
rs867271733 CA271428670	170	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA392830223 rs1442139936	171	H>Y		No	ClinGen gnomAD
rs753180915 CA7610858	173	A>E		No	ClinGen ExAC TOPMed gnomAD
CA7610857 rs753180915	173	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA392830201 rs1348909035	174	F>L		No	ClinGen gnomAD
rs1243447249 CA392830183	175	T>A		No	ClinGen TOPMed
rs1243447249 CA392830185	175	T>P		No	ClinGen TOPMed
CA392830166 rs1595786094	176	Y>S		No	ClinGen Ensembl
CA7610854 rs774674156	178	T>I		No	ClinGen ExAC TOPMed gnomAD
CA392830119 rs771326456	180	T>A		No	ClinGen ExAC gnomAD
CA271428633 rs149307777	180	T>I		No	ClinGen ESP TOPMed
CA7610853 rs771326456	180	T>P		No	ClinGen ExAC gnomAD
rs761452416 CA7610852	181	A>T		No	ClinGen ExAC gnomAD
CA7610850 rs539053246	182	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs150604668 CA392830069	184	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150604668 COSM1223431 CA7610847	184	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs778844103 CA7610845	185	A>T		No	ClinGen ExAC TOPMed gnomAD
CA392830055 rs1186967789	185	A>V		No	ClinGen TOPMed
COSM1708292 rs1208614343 CA392830045	186	L>F	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1208614343 CA392830046	186	L>V		No	ClinGen gnomAD
rs993604154 CA271428565	187	H>D		No	ClinGen TOPMed
rs1595786048 CA392830032	187	H>P		No	ClinGen Ensembl
rs141658779 CA7610842	188	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs771676896 CA7610829	191	R>C		No	ClinGen ExAC TOPMed gnomAD
rs948760638 CA271421236	191	R>H		No	ClinGen gnomAD
rs1322622890 CA392829614	192	W>C		No	ClinGen TOPMed
rs1180225015 CA392829602	193	Y>F		No	ClinGen TOPMed gnomAD
CA392829606 rs1180225015	193	Y>S		No	ClinGen TOPMed gnomAD
rs375982494 CA271421228	194	P>A		No	ClinGen ESP TOPMed
rs1484175613 CA392829577	195	S>F		No	ClinGen TOPMed gnomAD
rs894572812 CA271421222	196	S>C		No	ClinGen Ensembl
rs1449995646 CA392829543	198	T>N		No	ClinGen gnomAD
rs1291935581 CA392829535	199	T>A		No	ClinGen gnomAD
rs774440320 CA7610827	199	T>I		No	ClinGen ExAC TOPMed gnomAD
rs868644441 CA271421203	200	Q>K		No	ClinGen Ensembl
rs748379722 CA271421194	201	Q>*		No	ClinGen Ensembl
rs371422755 CA7610825	204	K>*		No	ClinGen ESP ExAC gnomAD
TCGA novel	204	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA392829466 rs1229809170	204	K>T		No	ClinGen gnomAD
rs147894930 CA7610823	206	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7610822 rs374250029	206	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7610824 rs147894930	206	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1351120995 CA392829422	207	Q>H		No	ClinGen gnomAD
rs1328444744 CA392829411	208	F>S		No	ClinGen gnomAD
CA7610821 rs532717350	209	C>S		No	ClinGen 1000Genomes ExAC gnomAD
CA392829382 rs985232954	210	C>S		No	ClinGen TOPMed gnomAD
CA271421139 rs985232954	210	C>W		No	ClinGen TOPMed gnomAD

No associated diseases with Q6ZRY4

2 regional properties for Q6ZRY4

Type	Name	Position	InterPro Accession
domain	RNA recognition motif domain	31 - 108	IPR000504
domain	RBPMS2, RNA recognition motif	30 - 105	IPR034787

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Cytoplasm, Stress granule	Localized to cytoplasmic stress granules after oxidative stress
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
protein homodimerization activity	Binding to an identical protein to form a homodimer.

4 GO annotations of biological process

Name	Definition
embryonic digestive tract morphogenesis	The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
negative regulation of BMP signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
negative regulation of smooth muscle cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation.
positive regulation of smooth muscle cell proliferation	Any process that activates or increases the rate or extent of smooth muscle cell proliferation.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P09012	SNRPA	U1 small nuclear ribonucleoprotein A	Homo sapiens (Human)	PR
P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	Homo sapiens (Human)	PR
Q8VC52	Rbpms2	RNA-binding protein with multiple splicing 2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSNLKPDGEH	GGSTGTGSGA	GSGGALEEEV	RTLFVSGLPV	DIKPRELYLL	FRPFKGYEGS
70	80	90	100	110	120
LIKLTARQPV	GFVIFDSRAG	AEAAKNALNG	IRFDPENPQT	LRLEFAKANT	KMAKSKLMAT
130	140	150	160	170	180
PNPSNVHPAL	GAHFIARDPY	DLMGAALIPA	SPEAWAPYPL	YTTELTPAIS	HAAFTYPTAT
190	200
AAAAALHAQV	RWYPSSDTTQ	QGWKYRQFC