AiPD: Autoinhibited Protein Database

Gene name	LYVE1 (CRSBP1, XLKD1)
Protein name	Lymphatic vessel endothelial hyaluronic acid receptor 1
Names	LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1, Extracellular link domain-containing protein 1
Species	Bos taurus (Bovine)
KEGG Pathway
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

135-322 (Predicted disordered autoinhibitory region) PR

135-322 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6UC88-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs134821996	30	I>L	No	EVA
rs452141209	39	M>V	No	EVA
rs475431631	41	V>A	No	EVA
rs437604621	44	V>G	No	EVA
rs457612834	57	A>S	No	EVA
rs443181689	86	S>G	No	EVA
rs469848507	162	L>M	No	EVA
rs519785581	185	A>V	No	EVA
rs523374902	188	L>P	No	EVA
rs801282579	211	A>T	No	EVA
rs722954404	212	V>I	No	EVA
rs797303452	218	S>L	No	EVA
rs458724404	244	A>V	No	EVA
rs476648124	248	F>V	No	EVA
rs435459203	253	G>V	No	EVA
rs455664505	257	C>G	No	EVA
rs472352299	261	R>G	No	EVA
rs443846963	262	Y>C	No	EVA
rs463813650	270	N>Y	No	EVA
rs459728965	283	V>A	No	EVA
rs479899890	287	K>Q	No	EVA
rs445096975	296	E>D	No	EVA
rs465223077	300	M>I	No	EVA
rs519977580	303	T>M	No	EVA
rs436916380	305	E>D	No	EVA

Type	Name	Position	InterPro Accession
ptm	EGF-type aspartate/asparagine hydroxylation site	589 - 600	IPR000152-1
ptm	EGF-type aspartate/asparagine hydroxylation site	744 - 755	IPR000152-2
domain	EGF-like domain	573 - 614	IPR000742-1
domain	EGF-like domain	732 - 769	IPR000742-2
domain	CUB domain	348 - 460	IPR000859-1
domain	CUB domain	461 - 573	IPR000859-2
domain	CUB domain	617 - 729	IPR000859-3
domain	CUB domain	773 - 885	IPR000859-4
domain	CUB domain	886 - 1002	IPR000859-5
domain	Peptidase M12A	146 - 346	IPR001506
domain	EGF-like calcium-binding domain	573 - 614	IPR001881-1
domain	EGF-like calcium-binding domain	729 - 769	IPR001881-2
domain	Peptidase, metallopeptidase	152 - 294	IPR006026
conserved_site	EGF-like calcium-binding, conserved site	573 - 598	IPR018097-1
conserved_site	EGF-like calcium-binding, conserved site	729 - 753	IPR018097-2
domain	Tolloid/BMP1 peptidase domain	147 - 346	IPR034036

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass membrane protein	Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments Undergoes ligand-dependent internalization and recycling at the cell surface (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
cargo receptor activity	Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
hyaluronic acid binding	Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.
transmembrane signaling receptor activity	Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.

Name	Definition
cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
hyaluronan catabolic process	The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
positive regulation of cellular extravasation	Any process that activates or increases the frequency, rate, or extent of cellular extravasation.
receptor-mediated endocytosis	An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y5Y7	LYVE1	Lymphatic vessel endothelial hyaluronic acid receptor 1	Homo sapiens (Human)	PR
P98066	TNFAIP6	Tumor necrosis factor-inducible gene 6 protein	Homo sapiens (Human)	PR
Q8BHC0	Lyve1	Lymphatic vessel endothelial hyaluronic acid receptor 1	Mus musculus (Mouse)	PR
O08859	Tnfaip6	Tumor necrosis factor-inducible gene 6 protein	Mus musculus (Mouse)	PR