Q6RUG5

PR
Gene name
Ica1l (Als2cr15)
Protein name
Islet cell autoantigen 1-like protein
Names
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog, Ica69-related protein
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:316432
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6RUG5

Entry ID Method Resolution Chain Position Source
AF-Q6RUG5-F1 Predicted AlphaFoldDB

No variants for Q6RUG5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6RUG5

No associated diseases with Q6RUG5

2 regional properties for Q6RUG5

Type Name Position InterPro Accession
domain Islet cell autoantigen Ica1, C-terminal 254 - 435 IPR006723
domain Arfaptin homology (AH) domain 15 - 247 IPR010504

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
acrosomal vesicle A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

1 GO annotations of molecular function

Name Definition
protein domain specific binding Binding to a specific domain of a protein.

2 GO annotations of biological process

Name Definition
regulation of transport Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q05084 ICA1 Islet cell autoantigen 1 Homo sapiens (Human) PR
Q3TY65 Ica1l Islet cell autoantigen 1-like protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MDSFEHLRPE DSQSVVSRMQ KKYWKTKQVF IKATGKKEDE HVVASDAELD AKLEVFHSIQ
70 80 90 100 110 120
ETCNELVKAV EKYQLRLNVI SEEENELGLF LTFQAERDAT QAGKMMGAAG KALCSSAKQR
130 140 150 160 170 180
LALCTPLSRL KQEVATFSQR AISDTSVTIN RMERARTEYR GALLWMKDAS QELDPDTFKQ
190 200 210 220 230 240
VEKFRKVQIQ VRNSKDCFDK LKMDVCQKVD LLGASRCNML SHSLATYQRT LLGFWEKTAQ
250 260 270 280 290 300
MMSQIQEACA GFHPYDFMAL KQLQDTPGNL TAEDKEEQTE GSCLSTNLNK VALSEEEERF
310 320 330 340 350 360
EREPAVARAL PRDSLEGDDF EKEFSFLSSL LSPTSSRASE CTQECQPACG SPSLMCQEPS
370 380 390 400 410 420
LGPGPLTSSS QFLPSRLFDL GLHADGAFNS WASQEGSEHS DTLPVPSQHP KKLKYLGPLS
430
NPDAIGHSDD ELLNA