Q3TY65
Gene name |
Ica1l (Als2cr15) |
Protein name |
Islet cell autoantigen 1-like protein |
Names |
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog, Ica69-related protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70375 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3TY65
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3TY65-F1 | Predicted | AlphaFoldDB |
23 variants for Q3TY65
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388472156 | 102 | A>T | No | EVA | |
| rs3388472938 | 134 | V>M | No | EVA | |
| rs3388474786 | 139 | Q>E | No | EVA | |
| rs3388472530 | 140 | R>* | No | EVA | |
| rs3388474785 | 209 | V>SDG* | No | EVA | |
| rs3388472698 | 210 | D>E | No | EVA | |
| rs3388472131 | 211 | L>* | No | EVA | |
| rs3388472464 | 212 | L>R | No | EVA | |
| rs3388472953 | 220 | L>M | No | EVA | |
| rs3388472494 | 234 | F>L | No | EVA | |
| rs258421062 | 254 | P>L | No | EVA | |
| rs227633506 | 256 | D>N | No | EVA | |
| rs3388472405 | 264 | Q>R | No | EVA | |
| rs3388473673 | 275 | T>I | No | EVA | |
| rs3388473252 | 298 | E>* | No | EVA | |
| rs3388472947 | 301 | R>T | No | EVA | |
| rs3388473372 | 322 | F>L | No | EVA | |
| rs3388472516 | 325 | E>G | No | EVA | |
| rs47437334 | 355 | C>G | No | EVA | |
| rs47437334 | 355 | C>R | No | EVA | |
| rs3388472184 | 362 | E>D | No | EVA | |
| rs3388473647 | 394 | T>A | No | EVA | |
| rs3390024203 | 395 | P>Y | No | EVA |
No associated diseases with Q3TY65
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| acrosomal vesicle | A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein domain specific binding | Binding to a specific domain of a protein. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transport | Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| spermatid development | The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSSEQLRAE | DNQSVVSRMQ | KNYWRTKQVF | IKATGKKEDE | HVVASDAELD | AKLEVFHSIQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ETCNELVKIV | EKYQLRLNVI | SEEENELGLF | LKFQAERDST | QAGEMMDAAG | KALCSSAKQR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LALCTPLSRL | KQEVATFSQR | AISDTLVTIN | RMERARTEYR | GALLWMKDAS | QELDPDTFKQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MEKFRKVQNQ | VRNSKDSFDK | LKKDVCQKVD | LLGASRCNML | SHSLTTYQRT | LLGFWEKTAQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MMTQIQEACA | GFHPYDFLAL | KRLQDTPGNL | TADCTEGQTE | GSCLTTDLNK | VALSEEEEEE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RFEREPAVAR | ALPRDSLEGD | DFEKEFSFLN | SLLSPTSSSA | SEFTQECQPA | CGSPCTGLTS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QEPSVGPGSL | TSSSQFLPSQ | LFDLGLHADG | AFNTPNNGNQ | DMSAWFNLFA | DLGPLSNPDA |
| 430 | |||||
| IGHSDDELLN | A |