Q6QD59

PR
Gene name
Bnip1
Protein name
Vesicle transport protein SEC20
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:224630
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

83-156 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6QD59

Entry ID Method Resolution Chain Position Source
AF-Q6QD59-F1 Predicted AlphaFoldDB

18 variants for Q6QD59

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389443956 4 P>S No EVA
rs3389443914 26 L>P No EVA
rs3389456789 50 K>R No EVA
rs3389451719 55 K>E No EVA
rs3389436282 77 L>V No EVA
rs3389436358 79 Q>L No EVA
rs3389448653 116 Q>H No EVA
rs3389451723 139 T>I No EVA
rs3389448679 164 V>F No EVA
rs3389395685 182 G>E No EVA
rs3389448707 186 L>M No EVA
rs3389436372 195 N>D No EVA
rs3389451710 197 R>L No EVA
rs3389404998 206 F>I No EVA
rs3389436353 209 L>Q No EVA
rs3389445797 214 A>T No EVA
rs3389445735 216 V>F No EVA
rs3389456757 227 F>S No EVA

No associated diseases with Q6QD59

No regional properties for Q6QD59

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6QD59

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type IV membrane protein
  • Mitochondrion membrane ; Single-pass type IV membrane protein
  • Localization to the mitochondrion is regulated by RNF186
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
COPI-coated vesicle A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
SNARE complex A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.

1 GO annotations of molecular function

Name Definition
SNAP receptor activity Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.

5 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
endoplasmic reticulum membrane fusion The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.
endoplasmic reticulum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P28791 SEC20 Protein transport protein SEC20 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MAAPQDVHVR ICNQEIVKFD LEVKALIQDI RDCSGPLSEL TELNTKVKEK FQQLKQRIQE
70 80 90 100 110 120
LEQSAREQDK ESEKQLLLQE VENHKKQMLS NQTSWRKANL TCKLAIDNLE KAELLQGGDS
130 140 150 160 170 180
LRQRKTTKES LAQTSSSITE SLMGISRMMS QQVQQSEEAM QTLVSSSRTL LDANEEFKSM
190 200 210 220
SGTIQLGRKL ITKYNRRELT DKLLIFLALA LFLATVLYIV KKRLFPFL