P28791
Gene name |
SEC20 (YDR498C, D9719.4) |
Protein name |
Protein transport protein SEC20 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR498C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P28791
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8EKI | EM | 450 A | A | 1-275 | PDB |
| AF-P28791-F1 | Predicted | AlphaFoldDB |
15 variants for P28791
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-1446892 | 32 | S>N | No | SGRP | |
| s04-1446847 | 47 | A>D | No | SGRP | |
| s04-1446784 | 68 | S>N | No | SGRP | |
| s04-1446601 | 129 | D>A | No | SGRP | |
| s04-1446587 | 134 | F>V | No | SGRP | |
| s04-1446581 | 136 | D>N | No | SGRP | |
| s04-1446523 | 155 | R>H | No | SGRP | |
| s04-1446451 | 179 | H>R | No | SGRP | |
| s04-1446128 | 287 | V>I | No | SGRP | |
| s04-1446119 | 290 | V>I | No | SGRP | |
| s04-1445995 | 331 | L>P | No | SGRP | |
| s04-1445990 | 333 | A>T | No | SGRP | |
| s04-1445933 | 352 | T>A | No | SGRP | |
| s04-1445924 | 355 | E>K | No | SGRP | |
| s04-1445872 | 372 | E>G | No | SGRP |
No associated diseases with P28791
No regional properties for P28791
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P28791 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic side of endoplasmic reticulum membrane | The side (leaflet) of the plasma membrane that faces the cytoplasm. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| Golgi to ER transport vesicle membrane | The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| SNARE complex | A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| SNAP receptor activity | Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. |
| vesicle fusion with endoplasmic reticulum | The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6QD59 | Bnip1 | Vesicle transport protein SEC20 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVVTFLQDLE | VLQDALLNNL | QKLSAISRRK | ESGESKHDNK | DSFAAIANEH | NDEEEEIEFE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DLVNIIESKV | SDFESVLKCS | IVEMTYKYPE | LKLQWEKSPR | YDQCDKLHIV | KLDKQMNEDI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YAQLVEELDF | VLQFVDWFYC | YRLKVKEILR | QHHKRDLAWN | DEKRDRAIKF | HAVDYDKLHQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTSSSSSLTS | TSMEKASTRE | KLLSKTKQLT | NNLVRGNQIL | QSGILQSDLN | LDELRAQTNS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LTQIDDKYTQ | FETVFKKTAD | LVKVLENASH | QEKRDVYLSL | GFLLCCVSWV | LWRRIFKLPV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KLGLWLLFKF | FKGILVTLGL | VKSYAGSSSS | LQAPSLVLNA | PILATTTTSS | ATSVEPFASV |
| 370 | 380 | ||||
| SAVSSIQRAV | DEAVDRIVSH | DEL |