Q6PCN7
PR
Gene name |
Hltf (Smarca3, Snf2l3, Zbu1) |
Protein name |
Helicase-like transcription factor |
Names |
P113, RING-type E3 ubiquitin transferase HLTF, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3, Sucrose nonfermenting protein 2-like 3, TNF-response element-binding protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20585 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6PCN7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6PCN7-F1 | Predicted | AlphaFoldDB |
37 variants for Q6PCN7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3392865919 | 25 | I>M | No | EVA | |
| rs3392771350 | 25 | I>V | No | EVA | |
| rs3392415789 | 26 | P>A | No | EVA | |
| rs3388618499 | 31 | S>P | No | EVA | |
| rs3388627880 | 44 | P>H | No | EVA | |
| rs3388621952 | 46 | D>H | No | EVA | |
| rs3388614515 | 47 | D>Y | No | EVA | |
| rs3412695324 | 48 | F>L | No | EVA | |
| rs3392811675 | 61 | G>E | No | EVA | |
| rs3388621614 | 74 | T>I | No | EVA | |
| rs214928430 | 158 | N>K | No | EVA | |
| rs3392825947 | 189 | G>* | No | EVA | |
| rs3392714143 | 189 | G>A | No | EVA | |
| rs3388619641 | 255 | E>D | No | EVA | |
| rs231288951 | 339 | R>L | No | EVA | |
| rs265729259 | 344 | M>I | No | EVA | |
| rs245388083 | 344 | M>T | No | EVA | |
| rs215084210 | 369 | K>N | No | EVA | |
| rs33562195 | 416 | V>A | No | EVA | |
| rs3388624167 | 446 | Q>K | No | EVA | |
| rs33563821 | 454 | M>T | No | EVA | |
| rs251483967 | 471 | A>T | No | EVA | |
| rs3388614558 | 593 | L>H | No | EVA | |
| rs3388623968 | 624 | L>V | No | EVA | |
| rs3388624130 | 767 | T>I | No | EVA | |
| rs256786700 | 783 | H>Q | No | EVA | |
| rs3388622062 | 792 | P>S | No | EVA | |
| rs3388621610 | 820 | S>I | No | EVA | |
| rs264667701 | 824 | K>T | No | EVA | |
| rs3388620091 | 828 | K>T | No | EVA | |
| rs3388618454 | 932 | A>V | No | EVA | |
| rs33572261 | 950 | I>V | No | EVA | |
| rs1135045473 | 986 | A>D | No | EVA | |
| rs1131905443 | 987 | N>S | No | EVA | |
| rs3388624168 | 993 | K>I | No | EVA | |
| rs33567784 | 996 | E>K | No | EVA | |
| rs3388624188 | 1001 | I>T | No | EVA |
No associated diseases with Q6PCN7
1 regional properties for Q6PCN7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Methyltransferase domain 25 | 92 - 189 | IPR041698 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nuclear matrix | The dense fibrillar network lying on the inner side of the nuclear membrane. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| RNA polymerase II transcription regulator complex | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent activity, acting on DNA | Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. |
| ATP-dependent chromatin remodeler activity | An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
| zinc ion binding | Binding to a zinc ion (Zn). |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| mRNA transcription by RNA polymerase II | The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| regulation of neurogenesis | Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYTFTRGPV | WKYSQSVQYG | SHENIPRLSY | STFLPHFEFQ | DIIPPDDFLT | SDEEQDLVLF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GTMRGQVVGL | RYYTGVVNNN | EMVALQREPN | NPYDKNAIKV | NNVNGNQVGH | IKREIAAAVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YIMDNKLAQV | EGVVPFGASN | TFTMPLYMTF | WGKEENRNVV | LEQLKKHGFK | LGPTPKTLGS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLENAWGSGR | AGPSYSRPAH | VAVQMTTDQL | KTEFDKLFED | LKEDDRTVEM | EPAEAIETPL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPHQKQALAW | MIARENSKEL | PPFWEQRNDL | YYNTITNFSV | KERPENVHGG | ILADDMGLGK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TLTAIAVILT | NFDDGRPLLS | KRGKKNHPGK | EYKDETIKRR | GSNMDKKEDG | HSESSTCGEE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PSISGTPEKS | SCTLSQLSSV | CPKRRKISVQ | YIESSDSEEI | ETSELPQKMK | GKLKNVQLNT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KSRVKGSSKV | KEDSKFALTF | FASATQRKML | KKGMSMMECS | EACDTGERTR | ATLIICPLSV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSNWIDQFGQ | HVKSEVHLNF | YVYYGPDRIR | DSAWLSKQDI | ILTTYNILTH | DYGTKDDSPL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HSIKWLRVIL | DEGHAIRNPN | AQQTKAVLEL | EAERRWVLTG | TPIQNSLKDL | WSLLSFLKLK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PFIDREWWYR | IIQRPVTTGD | EGGLRRLQSL | IKNITLRRTK | TSKIKGKPVL | ELPERKVFIQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HITLSEEERK | IYQSVKNEGK | AAIGRYFTEG | TVLAHYADVL | GLLLRLRQIC | CHTHLLTNGM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SSSGPSRSDT | PEELRKMLIE | KMKIILSSGS | DEECAICLDS | LTFPVITHCA | HVFCKPCICQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VIHSEQPHAK | CPLCRNEIHG | DNLLECPPEE | LACDSDKESS | MEWKSSSKIN | ALMHALIELR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TKDPNIKSLV | VSQFTTFLSL | IETPLKASGF | VFTRLDGSMA | QKKRVESIQR | FQNTEAGSPT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| IMLLSLKAGG | VGLNLCAASR | VFLMDPAWNP | AAEDQCFDRC | HRLGQKQEVI | ITKFIVKDSV |
| 970 | 980 | 990 | 1000 | ||
| EENMLKIQNT | KRDLAAGAFG | TKKTDANDMK | QAKINEIRTL | IDL |