Q6PAL8
PR
Gene name |
Dennd5a (Rab6ip1) |
Protein name |
DENN domain-containing protein 5A |
Names |
Rab6-interacting protein 1, Rab6IP1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19347 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q6PAL8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3CWZ | X-ray | 320 A | B | 707-1090 | PDB |
| AF-Q6PAL8-F1 | Predicted | AlphaFoldDB |
39 variants for Q6PAL8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388931707 | 63 | N>K | No | EVA | |
| rs3388937912 | 101 | P>L | No | EVA | |
| rs3388940545 | 118 | H>Q | No | EVA | |
| rs3388897381 | 122 | I>F | No | EVA | |
| rs3388917329 | 130 | T>I | No | EVA | |
| rs3388921085 | 131 | F>I | No | EVA | |
| rs3388937915 | 133 | F>S | No | EVA | |
| rs3388941955 | 137 | F>I | No | EVA | |
| rs3388940266 | 149 | A>S | No | EVA | |
| rs3388921114 | 164 | L>P | No | EVA | |
| rs3388936596 | 166 | A>P | No | EVA | |
| rs3388937889 | 173 | D>N | No | EVA | |
| rs3388940713 | 180 | G>S | No | EVA | |
| rs3388937861 | 198 | R>W | No | EVA | |
| rs3388943852 | 207 | I>V | No | EVA | |
| rs246992150 | 220 | R>W | No | EVA | |
| rs3388940271 | 276 | T>A | No | EVA | |
| rs3388941934 | 427 | H>L | No | EVA | |
| rs3388921168 | 460 | Y>H | No | EVA | |
| rs3388927171 | 486 | L>M | No | EVA | |
| rs3398386993 | 493 | S>C | No | EVA | |
| rs3388936597 | 495 | N>Y | No | EVA | |
| rs3388943781 | 496 | K>* | No | EVA | |
| rs3388934004 | 529 | A>V | No | EVA | |
| rs3388940723 | 556 | D>E | No | EVA | |
| rs3388937916 | 599 | P>T | No | EVA | |
| rs3388940686 | 665 | Y>* | No | EVA | |
| rs3388940237 | 703 | K>M | No | EVA | |
| rs3388937723 | 735 | L>Q | No | EVA | |
| rs3388940695 | 743 | I>N | No | EVA | |
| rs3412695445 | 753 | G>S | No | EVA | |
| rs3388943791 | 809 | Q>H | No | EVA | |
| rs3388937713 | 934 | L>M | No | EVA | |
| rs3388910860 | 1085 | S>F | No | EVA | |
| rs3388940732 | 1158 | P>S | No | EVA | |
| rs3388942016 | 1184 | D>E | No | EVA | |
| rs3388931711 | 1190 | N>K | No | EVA | |
| rs3388940523 | 1244 | T>S | No | EVA | |
| rs3388942005 | 1284 | G>C | No | EVA |
No associated diseases with Q6PAL8
9 regional properties for Q6PAL8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 9 - 70 | IPR001452 |
| domain | C2 DOCK-type domain | 421 - 617 | IPR027007 |
| domain | DOCKER domain | 1207 - 1617 | IPR027357 |
| domain | Dedicator of cytokinesis, N-terminal domain | 73 - 416 | IPR032376 |
| domain | DOCKER, Lobe A | 1202 - 1330 | IPR046769 |
| domain | DOCKER, Lobe B | 1388 - 1469 | IPR046770 |
| domain | DOCKER, Lobe C | 1508 - 1610 | IPR046773 |
| domain | Dedicator of cytokinesis protein 1/5, SH3 domain | 13 - 68 | IPR047025 |
| domain | Dedicator of cytokinesis protein 1, C2 domain | 424 - 619 | IPR047026 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| retromer complex | A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| small GTPase binding | Binding to a small monomeric GTPase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of neuron projection development | Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O95248 | SBF1 | Myotubularin-related protein 5 | Homo sapiens (Human) | PR |
| Q6ZUT9 | DENND5B | DENN domain-containing protein 5B | Homo sapiens (Human) | PR |
| Q6IQ26 | DENND5A | DENN domain-containing protein 5A | Homo sapiens (Human) | PR |
| A2RSQ0 | Dennd5b | DENN domain-containing protein 5B | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGGGGGGGS | APSRFADYFV | ICGLDTETGL | EPDELSALCQ | YIQASKARDG | ASPFISSTTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GENFEQTPLR | RTFKSKVLAR | YPENVDWNPF | DQDAVGMLCM | PKGLAFKTQA | DPREPQFHAF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IITREDGSRT | FGFALTFYEE | VTSKQICSAM | QTLYHMHNAE | YDVLHAPLAD | GGDQSGMEDG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EGIPGTKLQR | FNSYDISRDT | LYVSKCICLI | TPMSFMKACR | SVLQQLHQAV | TSPQPPPLPL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESYIYNVLYE | VPLPPPGRSL | KFSGVYGPII | CQRPSTNELP | LFDFPVKEVF | ELLGVENVFQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFTCALLEFQ | ILLYSQHYQR | LMTVAETITA | LMFPFQWQHV | YVPILPASLL | HFLDAPVPYL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MGLHSNGLDD | RSKLELPQEA | NLCFVDVDNH | FIELPEDLPQ | FPNKLEFVQE | VSEILMAFGV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPEGNLHCSE | SASKLKRIRA | SELVSDKRNG | NIAGSPLHSY | ELLKENETIA | RLQALVKRTG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VSLEKLEVRE | DPSSNKDFKV | QCDEEELRIY | QLNIQIREVF | ANRFTQMFAD | YEVFVIQPSQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DKESWFTNRE | QMQNFDKASF | LSDQPEPYLP | FLSRFLETQM | FASFIDNKIM | CHDDDDKDPV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LRVFDSRVDK | IRLLNVRTPT | LRTSMYQKCT | TVDEAEKAIE | LRLAKIDHTA | VHPHLLDMKI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GQGKYEPGFF | PKLQSDVLCT | GPASNKWTKR | NAPAQWRRKD | RQKQHTEHLR | LDNDQREKYI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QEARNMGSTI | RQPKLSNLSP | SVIAQTNWKF | VEGLLKECRN | KTKRMLVEKM | GREAVELGHG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EVNITGVEEN | TLIASLCDLL | ERIWSHGLQV | KQGKSALWSH | LLHYQENRQR | KLTSGSLSTS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GILLDSERRK | SDASAVMSPL | RISLIQDMRH | IQNIGEIKTD | VGKARAWVRL | SMEKKLLSRH |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LKQLLSDHEL | TKKLYKRYAF | LRCDDEKEQF | LYHLLSFNAV | DYFCFTNVFT | TILIPYHILI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VPSKKLGGSM | FTANPWICIS | GELGETQILQ | IPRNVLEMTF | ECQNLGKLTT | VQIGHDNSGL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| YAKWLVECVM | VRNEVTGHTY | KFPCGRWLGK | GMDDGSLERV | LVGELLTSLP | EVDERPCRTP |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| PLQQSPSVIR | RLVTISPNNK | PKLNTGQIQE | SIGEAVNGIV | KHFHKPEKER | GSLTLLLCGE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| CGLVSALEQA | FQHGFKSPRL | FKNVFIWDFL | EKAQTYYETL | EQNDVVPEEN | WHTRARNFCR |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| FVTAVNNTPR | NIGKDGKFQM | LVCLGARDHL | LHHWIALLAD | CPITAHMYED | VALIKDHTLV |
| 1270 | 1280 | ||||
| NSLIRVLQTL | QEFNITLDTS | LVKGIDI |