A2RSQ0
PR
Gene name |
Dennd5b |
Protein name |
DENN domain-containing protein 5B |
Names |
Rab6IP1-like protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320560 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2RSQ0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2RSQ0-F1 | Predicted | AlphaFoldDB |
51 variants for A2RSQ0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3397423413 | 158 | L>V | No | EVA | |
| rs3397535019 | 181 | I>KQILFETYKVSLLMS* | No | EVA | |
| rs3388872455 | 212 | H>L | No | EVA | |
| rs3388878054 | 247 | F>I | No | EVA | |
| rs3397496836 | 272 | R>G | No | EVA | |
| rs3388878040 | 375 | H>Q | No | EVA | |
| rs3388856202 | 378 | E>D | No | EVA | |
| rs3388856183 | 380 | P>R | No | EVA | |
| rs3388875184 | 385 | Q>E | No | EVA | |
| rs3413151117 | 385 | Q>H | No | EVA | |
| rs3388877973 | 436 | N>K | No | EVA | |
| rs3388873321 | 454 | I>L | No | EVA | |
| rs3388869560 | 486 | L>F | No | EVA | |
| rs3388869172 | 524 | T>S | No | EVA | |
| rs3388869201 | 589 | F>L | No | EVA | |
| rs3388852238 | 625 | E>D | No | EVA | |
| rs3388869152 | 627 | R>K | No | EVA | |
| rs3397623090 | 629 | M>I | No | EVA | |
| rs3388865326 | 641 | L>V | No | EVA | |
| rs3388856212 | 680 | A>T | No | EVA | |
| rs3388878023 | 686 | R>G | No | EVA | |
| rs3388869233 | 703 | K>T | No | EVA | |
| rs3388860558 | 711 | L>F | No | EVA | |
| rs3397634789 | 714 | N>K | No | EVA | |
| rs3388869588 | 750 | M>K | No | EVA | |
| rs3388877994 | 794 | L>Q | No | EVA | |
| rs3388869565 | 807 | L>P | No | EVA | |
| rs3388865683 | 815 | K>I | No | EVA | |
| rs3388872488 | 888 | S>Y | No | EVA | |
| rs3388871989 | 916 | L>P | No | EVA | |
| rs3388856122 | 918 | S>P | No | EVA | |
| rs3388852167 | 968 | T>I | No | EVA | |
| rs3397566800 | 1013 | V>A | No | EVA | |
| rs3388869151 | 1017 | I>N | No | EVA | |
| rs3388869566 | 1022 | Y>* | No | EVA | |
| rs3388834694 | 1027 | G>E | No | EVA | |
| rs3388864467 | 1028 | R>W | No | EVA | |
| rs3388865329 | 1031 | G>R | No | EVA | |
| rs3388856182 | 1086 | K>T | No | EVA | |
| rs3388852251 | 1094 | E>D | No | EVA | |
| rs3388846983 | 1098 | E>D | No | EVA | |
| rs3388873335 | 1147 | K>N | No | EVA | |
| rs3388865346 | 1166 | D>E | No | EVA | |
| rs3388872479 | 1202 | D>E | No | EVA | |
| rs3388878002 | 1207 | I>T | No | EVA | |
| rs3388875175 | 1225 | L>Q | No | EVA | |
| rs3388871997 | 1227 | E>* | No | EVA | |
| rs3388875166 | 1231 | I>N | No | EVA | |
| rs3388834696 | 1236 | E>D | No | EVA | |
| rs3388860643 | 1236 | E>Q | No | EVA | |
| rs3388869571 | 1238 | N>K | No | EVA |
No associated diseases with A2RSQ0
6 regional properties for A2RSQ0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Coagulation factor 5/8 C-terminal domain | 272 - 422 | IPR000421-1 |
| domain | Coagulation factor 5/8 C-terminal domain | 428 - 581 | IPR000421-2 |
| domain | CUB domain | 25 - 139 | IPR000859-1 |
| domain | CUB domain | 145 - 263 | IPR000859-2 |
| domain | MAM domain | 639 - 811 | IPR000998 |
| domain | Neuropilin, C-terminal | 847 - 923 | IPR022579 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| small GTPase binding | Binding to a small monomeric GTPase. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of triglyceride transport | Any process that activates or increases the frequency, rate or extent of triglyceride transport. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O95248 | SBF1 | Myotubularin-related protein 5 | Homo sapiens (Human) | PR |
| Q6IQ26 | DENND5A | DENN domain-containing protein 5A | Homo sapiens (Human) | PR |
| Q6ZUT9 | DENND5B | DENN domain-containing protein 5B | Homo sapiens (Human) | PR |
| Q6PAL8 | Dennd5a | DENN domain-containing protein 5A | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGSSAAPGP | GSGSSPAACR | FAHYFVLCGI | DADSGLEPDE | LAGENFDQSP | LRRTFKSKVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AHYPQNIEWN | PFDQDAVNML | CMPKGLSFRT | QADNKEPQFH | SFIITREDGS | RTYGFVLTFY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEVTSKQICT | AMQTLYQMHN | AEQYSSVYAS | SSCSMDSLAS | SIDEGDATSL | LKLQRYNSYD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| INRDTLYVSK | SICLITPLPF | MQACKKFLFQ | LHKAVTSQQP | PPLPLESYIH | NILYEVPLPP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PGRSLKFYGV | YEPVICQRPG | PNELPLSDYP | LREACELLGL | ENLVQVFTCV | LLEMQTLLYS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QDYQRLMTVA | EGITTLLFPF | QWQHVYVPIL | PASLLHFLDA | PVPYLMGLQS | KEGTDRSKLE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPQEANLCFV | DIDNHFIELP | EEFPQFPNKV | DFIQELSEVL | LQFGIPPEGS | LHSSESATKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KNMVLKDLAN | DKKNGNVPNN | SVSVYELLKG | SETIARLQAL | AKRTGVTMEK | IDLPASLSEK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EKDLKLQCEE | ADLRDSQLNV | QLREVFANRF | TQMFADYEAF | VIQTAQDMES | WLTNREQMQN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FDKASFLSDQ | PEPYLPFLSR | FIETQMFATF | IDNKIMSQWE | EKDPLLRVFD | SRIEKIRLYN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VRAPTLRTSI | YQKCSSLKEA | AQSIEQRLMK | MDHTAIHPHL | LDMKIGQGKY | EQGFFPKLQS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DVLATGPANN | NRWVSRSATA | QRRKERLRQS | SEHIGLDSDL | REKYMQEARS | LGKNLRQPKL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SDLSPAVIAQ | TNWKFVEGLL | KECRMKTKRM | LVEKMGHEAV | ELGHGEANIT | GLEENTLIAS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LCDLLERIWS | HGLLVKQGKS | ALWSHLLQFQ | DREEKQEHLT | DSPVALGPER | RKSDSGVMLP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TLRVSLIQDM | RHIQNMTEIK | TDVGRARAWI | RLSLEKKLLS | QHLKQLLSNQ | PLTKKLYKRY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| AFLRCEEERE | QFLYHLLSLN | AVDYFCFTSV | FTTIMIPYRS | VIIPIKKLSN | AIITSNPWIC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VSGELGDTGV | MQIPKNLLEM | TFECQNLGKL | TTVQIGHDNS | GLLAKWLVDC | VMVRNEITGH |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| TYRFPCGRWL | GKGVDDGSLE | RILIGELMTS | ASDEDLGKQC | RTPPQQKSPT | TTRRLSITSL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TGKPAKPNAG | QIQEGIGEAV | NNIVKHFHKP | EKERGSLTVL | LCGENGLVAA | LEQVFHHGFK |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| SARIFHKNVF | IWDFVEKAVA | YFETTDQILD | NEGDVLIQKP | SSKTFCHYVN | AINTAPRNIG |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| KDGKFQILVC | LGTRDHLLPQ | WIPLLAECPA | ITRMYEENAL | LRDHMTVNSL | IRILQTIQDF |
| 1270 | |||||
| TIVLEGSLIK | GVDV |