AiPD: Autoinhibited Protein Database

Gene name	Atl2 (Arl6ip2)
Protein name	Atlastin-2
Names	ADP-ribosylation factor-like protein 6-interacting protein 2, ARL-6-interacting protein 2, Aip-2
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:56298
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-66 (Predicted disordered autoinhibitory region) PR

1-66 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6PA06-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs266076387	7	A>V	No	EVA
rs3389494753	55	M>T	No	EVA
rs3389494814	65	L>F	No	EVA
rs3408079917	121	K>M	No	EVA
rs3389481840	138	T>*	No	EVA
rs3389460183	142	G>V	No	EVA
rs3389489674	153	W>*	No	EVA
rs3389448526	156	V>M	No	EVA
rs3389489696	161	R>*	No	EVA
rs3389475526	176	G>A	No	EVA
rs3389494809	178	F>S	No	EVA
rs3389440022	253	S>P	No	EVA
rs3389482972	256	L>V	No	EVA
rs3389429967	283	H>Y	No	EVA
rs3389494810	318	E>V	No	EVA
rs3389472310	333	A>V	No	EVA
rs3389448523	355	Y>*	No	EVA
rs3389482973	407	P>L	No	EVA
rs222962485	424	V>A	No	EVA
rs3389494811	437	G>R	No	EVA
rs3389448453	461	K>E	No	EVA
rs3389494760	479	F>L	No	EVA
rs3410685691	481	V>I	No	EVA

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	77 - 327	IPR000719
active_site	Serine/threonine-protein kinase, active site	196 - 208	IPR008271
binding_site	Protein kinase, ATP binding site	83 - 106	IPR017441

		Description
EC Number
Subcellular Localization	Endoplasmic reticulum membrane ; Multi-pass membrane protein	Localizes at endoplasmic reticulum (ER) three-way tubular junctions
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum tubular network membrane	The membrane of the endoplasmic reticulum tubular network.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

Name	Definition
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
identical protein binding	Binding to an identical protein or proteins.

Name	Definition
endoplasmic reticulum organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.
endoplasmic reticulum tubular network membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane.
Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
protein homooligomerization	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9VC57	atl	Atlastin	Drosophila melanogaster (Fruit fly)	PR
Q6ZN66	GBP6	Guanylate-binding protein 6	Homo sapiens (Human)	PR
Q8NHH9	ATL2	Atlastin-2	Homo sapiens (Human)	PR