AiPD: Autoinhibited Protein Database

Q6P6C2

Gene name	ALKBH5 (ABH5, OFOXD1)
Protein name	RNA demethylase ALKBH5
Names	Alkylated DNA repair protein alkB homolog 5, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
Species	Homo sapiens (Human)
KEGG Pathway	hsa:54890
EC number	1.14.11.53: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

15-112 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

15-112 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

12 structures for Q6P6C2

Entry ID	Method	Resolution	Chain	Position	Source
4NJ4	X-ray	202 A	A/B	66-292	PDB
4NRM	X-ray	217 A	A	66-292	PDB
4NRO	X-ray	230 A	A	66-292	PDB
4NRP	X-ray	180 A	A	66-292	PDB
4NRQ	X-ray	250 A	A	66-292	PDB
4O61	X-ray	190 A	A/B	74-294	PDB
4O7X	X-ray	178 A	A	66-292	PDB
4OCT	X-ray	228 A	A/B	74-294	PDB
7V4G	X-ray	210 A	A/B/C	74-292	PDB
7WKV	X-ray	210 A	A/C/E	74-292	PDB
7WL0	X-ray	250 A	A/C/E/G/I	74-292	PDB
AF-Q6P6C2-F1	Predicted				AlphaFoldDB

247 variants for Q6P6C2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1416725227 CA398646197	3	A>S		No	ClinGen gnomAD
CA398646195 rs1416725227	3	A>T		No	ClinGen gnomAD
TCGA novel	4	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA288425324 rs997201124	4	A>S		No	ClinGen TOPMed
CA398646208 rs1171937599	5	S>G		No	ClinGen TOPMed gnomAD
CA398646216 rs1460271736	6	G>D		No	ClinGen gnomAD
rs913465156 CA398646215	6	G>R		No	ClinGen gnomAD
rs913465156 CA288425327	6	G>S		No	ClinGen gnomAD
rs1323300455 CA398646220	7	Y>H		No	ClinGen gnomAD
CA398646230 rs1438823509	8	T>K		No	ClinGen gnomAD
CA398646232 rs1438823509	8	T>M		No	ClinGen gnomAD
CA398646289 rs1455988890	17	M>L		No	ClinGen TOPMed
rs1415461631 CA398646293	17	M>T		No	ClinGen gnomAD
CA398646308 rs1457334990	19	S>F		No	ClinGen gnomAD
rs1451855806 CA398646334	23	Y>C		No	ClinGen gnomAD
rs1288843691 CA398646332	23	Y>H		No	ClinGen gnomAD
CA288425342 rs1016845020	24	K>Q		No	ClinGen TOPMed
CA288425345 rs1001599161	25	A>T		No	ClinGen Ensembl
rs1223249251 CA398646348	25	A>V		No	ClinGen gnomAD
CA398646350 rs1477173466	26	G>S		No	ClinGen gnomAD
CA398646359 rs1252666463	27	S>N		No	ClinGen TOPMed
CA398646366 rs1426486555	28	R>Q		No	ClinGen gnomAD
TCGA novel	29	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA288425347 rs963583867	29	E>K		No	ClinGen TOPMed
CA398646378 rs1474501623	30	A>T		No	ClinGen gnomAD
CA398646381 rs1163070686	30	A>V		No	ClinGen TOPMed gnomAD
rs1391844043 CA398646382	31	A>T		No	ClinGen gnomAD
rs1316403804 CA398646390	32	A>S		No	ClinGen gnomAD
CA398646412 rs1242469413	36	A>T		No	ClinGen gnomAD
CA398646417 rs1283407160	36	A>V		No	ClinGen gnomAD
rs1356715248 CA398646418	37	A>P		No	ClinGen gnomAD
rs1356715248 CA398646420	37	A>T		No	ClinGen gnomAD
CA288425368 rs887898438	38	V>A		No	ClinGen TOPMed
CA398646427 rs887898438	38	V>E		No	ClinGen TOPMed
rs779550198	38	V>missing	Variant assessed as Somatic; 7.56e-05 impact. [NCI-TCGA]	No	NCI-TCGA
CA398646432 rs1283527374	39	A>D		No	ClinGen gnomAD
rs1487752522 CA398646435	40	A>T		No	ClinGen gnomAD
rs1216768513 CA398646443	41	A>T		No	ClinGen gnomAD
rs1170596628 CA398646447	42	A>T		No	ClinGen TOPMed
rs1187380646 CA398646455	43	A>S		No	ClinGen TOPMed gnomAD
CA398646453 rs1187380646	43	A>T		No	ClinGen TOPMed gnomAD
CA398646461 rs1369410099	44	A>S		No	ClinGen TOPMed gnomAD
rs1014963993 CA288425397	44	A>V		No	ClinGen TOPMed
rs1474016096 CA398646464	45	A>T		No	ClinGen TOPMed gnomAD
rs758673141 CA8426044	45	A>V		No	ClinGen ExAC TOPMed gnomAD
CA288425405 rs1016527303	46	A>T		No	ClinGen TOPMed gnomAD
rs1244526144 CA398646471	46	A>V		No	ClinGen gnomAD
CA8426045 rs780246148	47	A>T		No	ClinGen ExAC TOPMed gnomAD
rs768757008 CA8426047	48	A>T		No	ClinGen ExAC gnomAD
rs1340993145 CA398646486	49	E>K		No	ClinGen gnomAD
rs1352582996 CA398646497	50	P>L		No	ClinGen gnomAD
CA398646494 rs1306782653	50	P>S		No	ClinGen TOPMed gnomAD
CA398646492 rs1306782653	50	P>T		No	ClinGen TOPMed gnomAD
CA398646501 rs1240355443	51	Y>C		No	ClinGen gnomAD
CA398646508 rs1342171854	52	P>S		No	ClinGen gnomAD
CA8426049 rs748081999	53	V>A		No	ClinGen ExAC gnomAD
CA398646512 rs1199380758	53	V>M		No	ClinGen gnomAD
rs769720160 CA288425422	54	S>C		No	ClinGen ExAC TOPMed gnomAD
CA8426050 rs769720160	54	S>F		No	ClinGen ExAC TOPMed gnomAD
rs1444613519 CA398646519	54	S>P		No	ClinGen gnomAD
rs1413768781 CA398646522	55	G>R		No	ClinGen TOPMed
CA398646532 rs1440574837	56	A>V		No	ClinGen gnomAD
CA398646538 rs1393355592	57	K>M		No	ClinGen TOPMed gnomAD
CA398646536 rs1393355592	57	K>T		No	ClinGen TOPMed gnomAD
CA398646541 rs1173224616	58	R>C		No	ClinGen gnomAD
rs1032708221 CA288425435	59	K>E		No	ClinGen Ensembl
rs1416073756 CA398646559	60	Y>C		No	ClinGen gnomAD
CA398646592 rs1311080940	65	D>N		No	ClinGen gnomAD
rs767011110 CA398646601	66	P>S		No	ClinGen ExAC TOPMed gnomAD
rs767011110 CA8426056	66	P>T		No	ClinGen ExAC TOPMed gnomAD
rs61999283 CA288425446	67	E>*		No	ClinGen Ensembl
CA398646610 rs1347788665	67	E>D		No	ClinGen TOPMed gnomAD
rs61999283 CA288425445	67	E>Q		No	ClinGen Ensembl
rs1197251011 CA398646613	68	R>C		No	ClinGen gnomAD
rs1422958161 CA398646614	68	R>P		No	ClinGen TOPMed gnomAD
rs982195215 CA288425451	70	D>N		No	ClinGen TOPMed
rs779516667 CA8426058	71	Y>C		No	ClinGen ExAC gnomAD
CA398646639 rs1180895350	72	E>K		No	ClinGen gnomAD
CA398646668 rs1478973888	75	Q>H		No	ClinGen gnomAD
CA8426060 rs750849685	75	Q>L		No	ClinGen ExAC gnomAD
rs747203510 CA398646682	77	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs576498560 CA8426065	78	K>E		No	ClinGen 1000Genomes ExAC TOPMed
CA398646690 rs1388179496	79	E>K		No	ClinGen gnomAD
rs1301385983 CA398646703	80	E>A		No	ClinGen gnomAD
CA8426068 rs769914553	81	E>A		No	ClinGen ExAC TOPMed gnomAD
CA8426067 rs748052555	81	E>K		No	ClinGen ExAC gnomAD
rs199911950 CA8426069	84	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1597834785 CA398646736	85	V>G		No	ClinGen Ensembl
rs868728988 CA288425475	88	G>D		No	ClinGen Ensembl
CA8426072 rs201845081	93	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1269559774 CA398646795	94	L>F		No	ClinGen gnomAD
rs376859691 CA8426074	96	S>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs374187597 CA8426077	101	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA8426079 rs763328324	102	K>E		No	ClinGen ExAC gnomAD
rs561311814 CA8426080	105	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs751736728 CA8426081	106	R>L		No	ClinGen ExAC gnomAD
CA398573197 rs1220965113	112	S>F		No	ClinGen gnomAD
TCGA novel	112	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756235862 CA8426086	113	R>C		No	ClinGen ExAC gnomAD
CA398573207 rs1287162990	113	R>L		No	ClinGen TOPMed
CA8426085 rs756235862	113	R>S		No	ClinGen ExAC gnomAD
rs1244741057 CA398573212	114	A>S		No	ClinGen TOPMed
CA398573317 rs745633033	121	E>K		No	ClinGen ExAC gnomAD
CA8426090 rs745633033	121	E>Q		No	ClinGen ExAC gnomAD
CA8426091 rs201004949	122	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs760226514 CA8426093	126	R>W		No	ClinGen ExAC TOPMed gnomAD
CA398573509 rs1567672973	131	N>S		No	ClinGen Ensembl
TCGA novel	139	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767824688 CA8426100	140	T>A		No	ClinGen ExAC gnomAD
rs371248302 CA288407703	143	A>T		No	ClinGen ESP TOPMed
CA288407704 rs1023750539	146	Q>R		No	ClinGen TOPMed
rs1221113890 CA398574138	154	R>L		No	ClinGen TOPMed
rs1293577400 CA398574228	158	P>L		No	ClinGen TOPMed
rs778708217 CA8426106	158	P>S		No	ClinGen ExAC gnomAD
CA288407731 rs1020349428	160	D>E		No	ClinGen Ensembl
rs1235723796 CA398574457	166	E>G		No	ClinGen gnomAD
rs971071501 CA288407735	168	V>L		No	ClinGen Ensembl
rs1597834905 CA398574545	169	H>D		No	ClinGen Ensembl
rs372474496 CA8426109	170	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1437464000 CA398574592	170	Q>R		No	ClinGen TOPMed gnomAD
CA398574627 rs1597834915	172	V>G		No	ClinGen Ensembl
COSM120089 rs1282708778 CA398574672	174	Q>R	ovary [Cosmic]	No	ClinGen cosmic curated TOPMed
CA398574746 rs1359133006	177	V>G		No	ClinGen gnomAD
rs1466967345 CA398574786	178	E>D		No	ClinGen gnomAD
CA288407736 rs956896770	179	H>R		No	ClinGen TOPMed
CA398574830 rs1375068660	180	R>H		No	ClinGen TOPMed gnomAD
rs759998156 CA398574982	186	F>L		No	ClinGen ExAC gnomAD
CA398575004 rs1346120529	188	N>D		No	ClinGen TOPMed
CA398575124 rs1311566426	192	I>M		No	ClinGen gnomAD
CA8426118 rs775888304	192	I>V		No	ClinGen ExAC gnomAD
CA398575367 rs1178002817	201	I>T		No	ClinGen gnomAD
rs940741503 CA288407812	208	I>V		No	ClinGen Ensembl
CA8426125 rs373471903	212	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA398575726 rs1332435764	216	V>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	219	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	220	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372491826 CA288407865	225	A>V		No	ClinGen ESP TOPMed
rs1315958769 COSM3691336 CA398575907	229	G>D	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA8426134 rs772492243	235	K>R		No	ClinGen ExAC gnomAD
rs776053537 CA8426135	236	P>S		No	ClinGen ExAC gnomAD
CA8426136 rs761113226	237	I>V		No	ClinGen ExAC gnomAD
rs745817011 CA288407901	239	V>A		No	ClinGen Ensembl
rs889695478 CA288407916	244	L>F		No	ClinGen Ensembl
rs376470149 CA8426138	245	S>F		No	ClinGen ESP ExAC gnomAD
rs1200942190 CA398576099	245	S>P		No	ClinGen gnomAD
CA8426137 rs376470149	245	S>Y		No	ClinGen ESP ExAC gnomAD
rs371096564 CA8426141	248	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA398576137 rs1403829834	249	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA398576139 rs1323069792	249	R>H		No	ClinGen gnomAD
CA398576170 rs1350685998	252	S>N		No	ClinGen gnomAD
CA398576206 rs1296382448	255	V>L		No	ClinGen gnomAD
TCGA novel	256	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8426172 rs755667731	263	E>D		No	ClinGen ExAC TOPMed gnomAD
CA8426173 rs777475340	268	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1375683882 CA398579016	282	L>F		No	ClinGen gnomAD
rs1369512071 CA398581607	286	R>K		No	ClinGen TOPMed
rs1423920867 CA398581671	288	D>G		No	ClinGen TOPMed gnomAD
CA398581887 rs1451164195	296	S>T		No	ClinGen gnomAD
CA398581915 rs1200223677	297	L>M		No	ClinGen gnomAD
rs769558802 CA8426195	301	V>M		No	ClinGen ExAC gnomAD
rs752123279 CA8426197	302	L>S		No	ClinGen ExAC gnomAD
rs755598519 CA8426198	303	P>A		No	ClinGen ExAC gnomAD
rs781720809 CA8426199	304	P>A		No	ClinGen ExAC TOPMed gnomAD
rs377225153 CA288417012	306	Y>C		No	ClinGen ESP gnomAD
rs1303206051 CA398582187	309	D>E		No	ClinGen gnomAD
TCGA novel	309	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1347962377 CA398582195	310	R>C		No	ClinGen gnomAD
rs748504025 CA8426200	310	R>H		No	ClinGen ExAC gnomAD
rs1277969333 CA398582222	312	S>L		No	ClinGen gnomAD
CA398582238 rs1308387793	314	N>D		No	ClinGen gnomAD
rs756479743 CA8426201	314	N>K		No	ClinGen ExAC TOPMed gnomAD
CA398582257 rs777881500	315	N>I		No	ClinGen ExAC gnomAD
CA8426202 rs777881500	315	N>S		No	ClinGen ExAC gnomAD
CA398582253 rs1355580421	315	N>Y		No	ClinGen TOPMed
rs1400438509 CA398582274	316	R>K		No	ClinGen Ensembl
CA8426203 rs749475182	317	D>A		No	ClinGen ExAC gnomAD
CA398582305 rs1012911005	318	P>H		No	ClinGen TOPMed gnomAD
rs1012911005 CA288417023	318	P>L		No	ClinGen TOPMed gnomAD
rs771007455 CA8426204	318	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1191347876 CA398582316	319	A>G		No	ClinGen gnomAD
CA398582336 rs1247088205	321	K>Q		No	ClinGen TOPMed
CA8426207 rs772033885	323	K>M		No	ClinGen ExAC TOPMed gnomAD
rs772033885 CA398582371	323	K>R		No	ClinGen ExAC TOPMed gnomAD
CA398582375 rs772033885	323	K>T		No	ClinGen ExAC TOPMed gnomAD
rs760405725 CA8426209	324	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs775474036 CA8426208	324	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1163702519 CA398582418 COSM1182544	327	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	327	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	329	A>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371868380 CA8426212	330	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8426213 rs764967708	331	P>A		No	ClinGen ExAC TOPMed gnomAD
rs1597843364 CA398582492	332	D>N		No	ClinGen Ensembl
rs757592449 CA8426243	337	P>L		No	ClinGen ExAC TOPMed gnomAD
CA398582990 rs1174648070	338	R>Q		No	ClinGen gnomAD
rs1164248193 CA398582989	338	R>W		No	ClinGen TOPMed
rs1555551372 CA8426244	344	K>R		No	ClinGen Ensembl
TCGA novel	346	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8426246 rs779127018	348	R>Q		No	ClinGen ExAC gnomAD
rs919866254 CA288417471	349	R>C		No	ClinGen Ensembl
rs1339081895 CA398583069	349	R>H		No	ClinGen gnomAD
CA8426248 rs758409355	350	S>L		No	ClinGen ExAC gnomAD
CA398583123 rs1375550598	353	L>P		No	ClinGen gnomAD
CA8426253 rs748007768	356	H>Y		No	ClinGen ExAC gnomAD
CA8426255 rs773031505	357	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8426254 rs767112785 COSM1520496	357	R>W	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs770364449 CA8426257	358	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs762603610 COSM976234 CA8426256	358	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA8426258 rs773971516	359	R>G		No	ClinGen ExAC gnomAD
CA398583246 rs758966619	361	S>G		No	ClinGen ExAC gnomAD
rs758966619 CA8426259	361	S>R		No	ClinGen ExAC gnomAD
CA8426260 rs764631695	362	F>Y		No	ClinGen ExAC gnomAD
rs1409620968 CA398583291	363	S>I		No	ClinGen gnomAD
rs754292160 CA8426261	363	S>R		No	ClinGen ExAC gnomAD
CA398583303 rs1212473184	365	E>A		No	ClinGen TOPMed
rs762193110 CA8426262	365	E>K		No	ClinGen ExAC gnomAD
rs912403946 CA288417528	366	N>K		No	ClinGen Ensembl
rs765516157 CA8426263	368	W>C		No	ClinGen ExAC gnomAD
CA8426264 rs750655723	369	R>C	Variant assessed as Somatic; 4.638e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA398583335 rs1567678122	369	R>H		No	ClinGen Ensembl
rs1555551378 CA398583347	371	S>L		No	ClinGen Ensembl
CA398583350 rs1226170428	372	Y>H		No	ClinGen TOPMed
rs751699434 CA8426267 COSM1381310	373	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1193352172 CA398583375	375	S>L		No	ClinGen TOPMed gnomAD
rs781303076 CA8426269	376	E>G		No	ClinGen ExAC gnomAD
rs754991517 CA8426268	376	E>K		No	ClinGen ExAC gnomAD
CA8426271 rs552116660	378	C>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA398583403 COSM1640608 rs1490657892	379	S>C	stomach [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA398583402 rs1490657892	379	S>F		No	ClinGen TOPMed gnomAD
rs777657592 CA8426272	380	E>D		No	ClinGen ExAC gnomAD
rs749027485 CA8426273	381	A>E		No	ClinGen ExAC gnomAD
rs373570928 CA8426274	382	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA8426275 rs773848076	383	G>S		No	ClinGen ExAC gnomAD
rs759105052 CA8426276	384	S>I		No	ClinGen ExAC gnomAD
CA8426278 rs777123260	385	P>R		No	ClinGen ExAC gnomAD
CA8426279 rs376329155	386	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA398583441 rs1304956863	386	A>V		No	ClinGen gnomAD
CA288417585 rs267604766	387	R>*		No	ClinGen TOPMed
CA288417581 rs267604766	387	R>G		No	ClinGen TOPMed
CA288417588 rs947071965	387	R>Q		No	ClinGen TOPMed gnomAD
CA398583464 rs1270505304	390	K>R		No	ClinGen gnomAD
CA398583478 rs1243236963	392	R>Q		No	ClinGen TOPMed gnomAD
CA8426280 rs765718566	392	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	393	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1192475606 CA398583482	393	R>W		No	ClinGen TOPMed
CA398583487 rs1597844115	394	H>D		No	ClinGen Ensembl
CA398583489 rs1597844120	394	H>P		No	ClinGen Ensembl
TCGA novel	395	H>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q6P6C2

1 regional properties for Q6P6C2

Type	Name	Position	InterPro Accession
domain	Alpha-ketoglutarate-dependent dioxygenase AlkB-like	153 - 275	IPR027450

Functions

		Description
EC Number	1.14.11.53	With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization	Nucleus speckle	Promotes formation and localizes to paraspeckles, a nuclear membraneless organelle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
2-oxoglutarate-dependent dioxygenase activity	Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
metal ion binding	Binding to a metal ion.
mRNA N6-methyladenosine dioxygenase activity	Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde.
oxidative RNA demethylase activity	Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
RNA binding	Binding to an RNA molecule or a portion thereof.

7 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
mRNA export from nucleus	The directed movement of mRNA from the nucleus to the cytoplasm.
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
oxidative single-stranded RNA demethylation	Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.
regulation of mRNA stability	Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
response to hypoxia	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
E1BH29	ALKBH5	RNA demethylase ALKBH5	Bos taurus (Bovine)	PR
Q3TSG4	Alkbh5	RNA demethylase ALKBH5	Mus musculus (Mouse)	PR
Q66JG8	alkbh5	RNA demethylase ALKBH5	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR

10	20	30	40	50	60
MAAASGYTDL	REKLKSMTSR	DNYKAGSREA	AAAAAAAVAA	AAAAAAAAEP	YPVSGAKRKY
70	80	90	100	110	120
QEDSDPERSD	YEEQQLQKEE	EARKVKSGIR	QMRLFSQDEC	AKIEARIDEV	VSRAEKGLYN
130	140	150	160	170	180
EHTVDRAPLR	NKYFFGEGYT	YGAQLQKRGP	GQERLYPPGD	VDEIPEWVHQ	LVIQKLVEHR
190	200	210	220	230	240
VIPEGFVNSA	VINDYQPGGC	IVSHVDPIHI	FERPIVSVSF	FSDSALCFGC	KFQFKPIRVS
250	260	270	280	290	300
EPVLSLPVRR	GSVTVLSGYA	ADEITHCIRP	QDIKERRAVI	ILRKTRLDAP	RLETKSLSSS
310	320	330	340	350	360
VLPPSYASDR	LSGNNRDPAL	KPKRSHRKAD	PDAAHRPRIL	EMDKEENRRS	VLLPTHRRRG
370	380	390
SFSSENYWRK	SYESSEDCSE	AAGSPARKVK	MRRH