Q6NXK7

PR
Gene name
Dpp10
Protein name
Inactive dipeptidyl peptidase 10
Names
Dipeptidyl peptidase X, DPP X
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:269109
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NXK7

Entry ID Method Resolution Chain Position Source
AF-Q6NXK7-F1 Predicted AlphaFoldDB

No variants for Q6NXK7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NXK7

No associated diseases with Q6NXK7

2 regional properties for Q6NXK7

Type Name Position InterPro Accession
domain Peptidase S9, prolyl oligopeptidase, catalytic domain 582 - 784 IPR001375
domain Dipeptidylpeptidase IV, N-terminal domain 134 - 500 IPR002469

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

3 GO annotations of molecular function

Name Definition
potassium channel regulator activity Binds to and modulates the activity of a potassium channel.
serine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

4 GO annotations of biological process

Name Definition
positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
regulation of potassium ion transmembrane transport Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P81425 DPP4 Dipeptidyl peptidase 4 Bos taurus (Bovine) PR
Q10MJ1 GEP Probable glutamyl endopeptidase, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q18253 dpf-2 Dipeptidyl peptidase family member 2 Caenorhabditis elegans PR
10 20 30 40 50 60
MKQEQQPTPG ARATQSQPAD QELGSNSPPQ RNWKGIAIAL LVILVVCSLI TMSVILLTPD
70 80 90 100 110 120
ELTNSSETRL SLEELLGKGF GLHNPEPRWI NDTVVVYKTN NGHVMKLNTE SNASTLLLDN
130 140 150 160 170 180
STFVTFKASR HSLSPDLKYV LLAYDVKQIF HYSFTASYLI YNIHTGEVWE LNPPEVEDSV
190 200 210 220 230 240
LQYAAWGVQG QQLIYIFENN IYYQPDIKSS SLRLTSSGKE GIIFNGIADW LYEEELLHSH
250 260 270 280 290 300
IAHWWSPDGE RLAFLMINDS LVPNMIIPRF TGALYPKAKQ YPYPKAGQAN PSVKLYVVNL
310 320 330 340 350 360
YGPTHTLELM PPDIFKSREY YITMVKWVSN TRTVVRWLNR PQNISILTLC ESTTGACSRK
370 380 390 400 410 420
YEMTSDTWLS KQNEEPVFSR DGSKFFMTVP VKQGGRGEFH HIAMFLVQSK SEQITVRHLT
430 440 450 460 470 480
SGNWEVIRIL AYDETTQKIY FLSTESSPQG RQLYSASTEG LLNRDCISCN FMKEDCTYFD
490 500 510 520 530 540
ASFSPMNQHF LLFCEGPKVP VVSLHITDNP SRYFLLENNS VMKETIQKKK LAKRETRILH
550 560 570 580 590 600
IDDYELPLQL SFPKDFMEKN QYALLLIMDE EPGGQMVTDK FHVDWDSVLI DTDNVIVARF
610 620 630 640 650 660
DGRGSGFQGL KVLQEIHRRI GSVEAKDQVA AVKYLLKQPY IDSKRLSIFG KGYGGYIASM
670 680 690 700 710 720
ILKSDEKFFK CGAVVAPISD MKLYASAFSE RYLGMPSKEE STYQASSVLH NIHGLKEENL
730 740 750 760 770 780
LIIHGTADTK VHFQHSAELI KHLIKAGVNY TLQVYPDEGY HISDKSKHHF YSTILRFFSD
790
CLKEEVSVLP QEPEEDE