Q18253

PR
Gene name
dpf-2 (C27C12.7)
Protein name
Dipeptidyl peptidase family member 2
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C27C12.7
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

27-104 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q18253

Entry ID Method Resolution Chain Position Source
AF-Q18253-F1 Predicted AlphaFoldDB

No variants for Q18253

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q18253

No associated diseases with Q18253

3 regional properties for Q18253

Type Name Position InterPro Accession
domain Zinc finger, ZZ-type 222 - 279 IPR000433
domain EF-hand domain, type 1 8 - 118 IPR015153
domain EF-hand domain, type 2 124 - 217 IPR015154

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.
dipeptidyl-peptidase activity Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.
serine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P81425 DPP4 Dipeptidyl peptidase 4 Bos taurus (Bovine) PR
Q6NXK7 Dpp10 Inactive dipeptidyl peptidase 10 Mus musculus (Mouse) PR
Q10MJ1 GEP Probable glutamyl endopeptidase, chloroplastic Oryza sativa subsp japonica (Rice) PR
10 20 30 40 50 60
MENDNYDVEE QGCSVFNGKH GYFARSCCVV FILIICVIFV FSVIFTFMQN PINLNSDNGF
70 80 90 100 110 120
NQTSGNTSSL EATTLKPKFS SLMTTTRRFT FEQLFSGKQF LVDYYDYIWL PDGSFVQMND
130 140 150 160 170 180
DFTIRKQMKK IPLGSSVAEP FFNNGEYVKA LSSNMKYAYG SKKVNELWRH SAEYLYHIVK
190 200 210 220 230 240
INNKTVSTEQ WHVGPEENSL IQAFYWNPNA SSNDFVYVHN YNLYYQKDPE KPDGAIQLTV
250 260 270 280 290 300
GGSTFNRFGL ANWLYEEEIL EASSAVWWSP SGRYVSYLRF DDREVNRIFL PKYTDDDSYV
310 320 330 340 350 360
EYFELPYPKA GVQNNTLVTQ YIWDSENHKI VETAPPNELS AANGDYYVLT NKWITMPRNG
370 380 390 400 410 420
SDLGEERLVT VWANRDQNHV YFSLCNEQDC VMALSFQFSI DNRQLWVSPK DVRGVFPTET
430 440 450 460 470 480
GFLTVLPHKH DDGNIYNHVA HVELDGTGTG KITKWIGENF DVILVLGYSS KIDALTFSAY
490 500 510 520 530 540
GDGVGEFSTY IVREAMYSNK KTTLQKVTDQ FEDCKTLGSQ SADPTGQRIV VQCEKPFDNT
550 560 570 580 590 600
RLYLVDVVDT TKKIMLEGGT KAVIPFDVPN MKFGKLKLPS GIDGHYMMLT PANLLDGAKI
610 620 630 640 650 660
PLLLDIYGGP DSKQVFQKTP TAHAIQIVSQ YDIAYARIDV RGTGGRGWDV KEAVYRKLGD
670 680 690 700 710 720
AEVVDTLDMI RAFINTFGFI DEDRIAVMGW SYGGFLTSKI AIKDQGELVK CAISIAPVTD
730 740 750 760 770 780
FKYYDSAYTE RYLGQPAENL QGYINTNVIP HARNVTNVKY LLAHGERDDN VHYQNSARWS
790 800 810 820
EALQQNGIHF TQLVYANEAH SLSHKLFHLY GEVQRFLMND CFKSNLDLL