Q6NX08
Gene name |
wdr12 |
Protein name |
Ribosome biogenesis protein wdr12 |
Names |
WD repeat-containing protein 12 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:321652 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NX08
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NX08-F1 | Predicted | AlphaFoldDB |
No variants for Q6NX08
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6NX08 | |||||
No associated diseases with Q6NX08
11 regional properties for Q6NX08
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 91 - 180 | IPR001680-1 |
| repeat | WD40 repeat | 178 - 217 | IPR001680-2 |
| repeat | WD40 repeat | 245 - 324 | IPR001680-3 |
| repeat | WD40 repeat | 330 - 373 | IPR001680-4 |
| repeat | WD40 repeat | 374 - 412 | IPR001680-5 |
| domain | NLE | 5 - 70 | IPR012972 |
| conserved_site | WD40 repeat, conserved site | 270 - 284 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 357 - 371 | IPR019775-2 |
| repeat | G-protein beta WD-40 repeat | 270 - 284 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 311 - 325 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 357 - 371 | IPR020472-3 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| PeBoW complex | A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively. |
| preribosome, large subunit precursor | A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribonucleoprotein complex binding | Binding to a complex of RNA and protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9FKH1 | SAP | Transcriptional regulator STERILE APETALA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQLQARFFT | ENKKYLVDDV | PFSIPASSEV | ADLSGVINKL | LEAKNAGHKH | VEFDFLVRGQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLRTSLDKHI | ETENISTEEV | VEIEYVEKFT | APQPEECIMH | DDWISSVEAD | SEWILTGSYD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KTARIWSMEG | KAVMTVAGHA | DVVKDVAWVK | RDGLNSVLLT | ASLDQTVMLW | EWNSERNKVK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARHCCRGHAG | SVDTIAVDPT | RTKFCSGSWD | KMLKIWSAVP | TEEEDEIEEP | NRPRKKQKTE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QMGLTRTPLM | TLSGHNEAVS | SVLWMDADEL | CSASWDHTIR | LWDAETGGQK | STLSGSKVFN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CISYSPLCRR | LASGSTDRHV | RLWDPRSKDG | SLVLLSLTSH | NGWVTAVRWA | PSHEHQLVSG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SLDNVVKLWD | TRSCKAPLYD | LAAHEDKVLC | ADWTENGLIL | SGGADNKLYT | YRYAACVSDA |
| GA |