Q6NWA8

PR
Gene name
tada1 (tada1l, zgc:85851)
Protein name
Transcriptional adapter 1
Names
Transcriptional adapter 1-like protein
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:402899
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

53-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NWA8

Entry ID Method Resolution Chain Position Source
AF-Q6NWA8-F1 Predicted AlphaFoldDB

No variants for Q6NWA8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6NWA8

No associated diseases with Q6NWA8

No regional properties for Q6NWA8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6NWA8

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
SAGA complex A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).

1 GO annotations of molecular function

Name Definition
transcription coactivator activity A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q99LM9 Tada1 Transcriptional adapter 1 Mus musculus (Mouse) PR
Q5BJQ7 Tada1 Transcriptional adapter 1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAAHASELEI AKKNLTDAIG ENVKHYWANL KLWFKQKISK EEFDLEARRL LAQDNVHVHN
70 80 90 100 110 120
DFLLAILTRC QIIVSTSEGP GSLQWSGGSA SKPGKPSRGK KKFPSVRQKF DHRFQPQNPL
130 140 150 160 170 180
AGVPVFSPRE AEEEELKLSA QTLLLPSRGQ LEARMMVSAF ESDLDSVAED AVSCMLCALQ
190 200 210 220 230 240
VHLKDILTAL VSRRKAYRLR DGHFLYAFGS DVTPRPYLKN SLPAYHSATE CPPASASLPA
250 260 270 280 290 300
AAPARVCPDE AEQNAALLLA CSADTAAPPL QPVSVYDLLE ALQVQRRVMP SHSMYALNME
310 320 330
RILARLWHPS HEELEQDHIH RQHLALRDGL VT