Q6NVG5
Gene name |
Mreg |
Protein name |
Melanoregulin |
Names |
Dilute suppressor protein, Whn-dependent transcript 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:381269 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q6NVG5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6CMY | NMR | - | A | 33-214 | PDB |
| AF-Q6NVG5-F1 | Predicted | AlphaFoldDB |
11 variants for Q6NVG5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388477211 | 102 | R>S | No | EVA | |
| rs3388475626 | 104 | V>* | No | EVA | |
| rs3388476847 | 105 | R>W | No | EVA | |
| rs3388476903 | 106 | N>K | No | EVA | |
| rs3388476161 | 106 | N>S | No | EVA | |
| rs3388476139 | 107 | R>* | No | EVA | |
| rs3390170418 | 108 | W>C | No | EVA | |
| rs3388475010 | 109 | R>G | No | EVA | |
| rs30659662 | 122 | D>E | No | EVA | |
| rs3390164478 | 143 | R>P | No | EVA | |
| rs3390160671 | 193 | K>* | No | EVA |
No associated diseases with Q6NVG5
No regional properties for Q6NVG5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6NVG5 | |||
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| cytoplasmic vesicle membrane | The lipid bilayer surrounding a cytoplasmic vesicle. |
| intrinsic component of organelle membrane | The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| melanosome membrane | The lipid bilayer surrounding a melanosome. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| developmental pigmentation | The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. |
| melanocyte differentiation | The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. |
| melanosome localization | Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell. |
| melanosome transport | The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| minus-end-directed organelle transport along microtubule | The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. |
| phagosome maturation | A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. |
| pigmentation | The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLRRWLRSA | CCCCPCRCLE | EPARPEKEPL | VSGNNPYSSF | GATLERDDEK | NLWSMPHDVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HTEADDDRIL | YNLIVIRNQQ | TKDSEEWQRL | NYDIYTLRQI | RREVRNRWRR | ILEDLGFQRE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ADSLLSVTKL | STMSDSKNTR | KAREMLLKLA | EETSIFPASW | ELSERYLLVV | DRLIALDAAE |
| 190 | 200 | 210 | |||
| DFFKIASQMY | PKKPGVPCLV | DGQRKLHCLP | FPSP |