Q6GQM0

PR
Gene name
mreg (si:ch211-51m24.2, zgc:91968)
Protein name
Melanoregulin
Names
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:431714
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6GQM0

Entry ID Method Resolution Chain Position Source
AF-Q6GQM0-F1 Predicted AlphaFoldDB

No variants for Q6GQM0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6GQM0

No associated diseases with Q6GQM0

No regional properties for Q6GQM0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6GQM0

Functions

Description
EC Number
Subcellular Localization
  • Apical cell membrane ; Peripheral membrane protein
  • Melanosome membrane ; Lipid-anchor
  • Lysosome membrane ; Lipid-anchor
  • Cytoplasmic vesicle membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
intrinsic component of organelle membrane The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
late endosome membrane The lipid bilayer surrounding a late endosome.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
melanosome membrane The lipid bilayer surrounding a melanosome.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

3 GO annotations of biological process

Name Definition
melanosome localization Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell.
melanosome transport The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
phagosome maturation A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8N565 MREG Melanoregulin Homo sapiens (Human) PR
Q6NVG5 Mreg Melanoregulin Mus musculus (Mouse) PR
10 20 30 40 50 60
MGTAFKKFCI KFCCCCCCED EDEEEKAPLI GHDTLDYFDR EAKKRRDQET NLWSEPGDPS
70 80 90 100 110 120
HSERDDDRVL YKLLQCRQQT QPGSRGYRRL SIDIEAMRDV RREVRDKWKM ILENLGFMAE
130 140 150 160 170 180
AESLLNVSAS ASYDRMRNAA SARSLLQTLH TETSLFNSKE PPPERYLFIL DRLIYLDAAE
190 200 210 220 230
DFVAKARRFY PPKDDDEEEE SNPLGINLPL LLSRMNQNIS GGEDEDEDES EPDD