Q6NKX5
Gene name |
POT1B |
Protein name |
Protection of telomeres protein 1b |
Names |
AtPOT1b, Protection of telomeres protein 2, AtPot2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G06310 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NKX5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NKX5-F1 | Predicted | AlphaFoldDB |
42 variants for Q6NKX5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_1928486_G_C | 7 | D>H | No | 1000Genomes | |
| ENSVATH10608302 | 17 | A>T | No | 1000Genomes | |
| ENSVATH06930855 | 25 | V>L | No | 1000Genomes | |
| ENSVATH13940393 | 29 | G>E | No | 1000Genomes | |
| ENSVATH03029987 | 38 | N>Y | No | 1000Genomes | |
| ENSVATH10608303 | 66 | T>N | No | 1000Genomes | |
| tmp_5_1928786_A_G | 76 | I>V | No | 1000Genomes | |
| tmp_5_1928928_C_T | 92 | R>W | No | 1000Genomes | |
| ENSVATH06930860 | 101 | T>I | No | 1000Genomes | |
| ENSVATH13940475 | 108 | L>F | No | 1000Genomes | |
| tmp_5_1929033_C_G | 127 | L>V | No | 1000Genomes | |
| ENSVATH06930863 | 128 | M>L | No | 1000Genomes | |
| tmp_5_1929512_G_C | 190 | D>H | No | 1000Genomes | |
| ENSVATH08405899 | 202 | K>N | No | 1000Genomes | |
| ENSVATH06930871 | 207 | P>S | No | 1000Genomes | |
| ENSVATH06930873 | 242 | A>V | No | 1000Genomes | |
| tmp_5_1929903_C_A | 273 | S>Y | No | 1000Genomes | |
| tmp_5_1930056_T_A | 293 | C>* | No | 1000Genomes | |
| tmp_5_1930064_A_G | 296 | K>R | No | 1000Genomes | |
| ENSVATH10608396 | 299 | P>L | No | 1000Genomes | |
| ENSVATH06930875 | 299 | P>S | No | 1000Genomes | |
| ENSVATH06930877 | 304 | I>V | No | 1000Genomes | |
| tmp_5_1930093_C_T | 306 | R>C | No | 1000Genomes | |
| ENSVATH10608397 | 306 | R>H | No | 1000Genomes | |
| ENSVATH00608805 | 311 | S>L | No | 1000Genomes | |
| ENSVATH03029997 | 312 | H>P | No | 1000Genomes | |
| ENSVATH10608398 | 314 | E>D | No | 1000Genomes | |
| ENSVATH00608806 | 329 | M>I | No | 1000Genomes | |
| tmp_5_1930263_A_G | 336 | N>D | No | 1000Genomes | |
| tmp_5_1930427_C_A | 358 | L>I | No | 1000Genomes | |
| ENSVATH00608807 | 362 | N>S | No | 1000Genomes | |
| ENSVATH06930885 | 364 | N>D | No | 1000Genomes | |
| tmp_5_1930446_A_T | 364 | N>I | No | 1000Genomes | |
| ENSVATH00608808 | 374 | A>T | No | 1000Genomes | |
| tmp_5_1930502_T_C | 383 | Y>H | No | 1000Genomes | |
| tmp_5_1930509_A_C | 385 | D>A | No | 1000Genomes | |
| tmp_5_1930508_G_A | 385 | D>N | No | 1000Genomes | |
| ENSVATH00608809 | 394 | D>H | No | 1000Genomes | |
| ENSVATH06930886 | 398 | E>K | No | 1000Genomes | |
| tmp_5_1930742_C_G | 438 | Q>E | No | 1000Genomes | |
| tmp_5_1930743_A_T | 438 | Q>L | No | 1000Genomes | |
| ENSVATH06930888 | 449 | T>N | No | 1000Genomes |
No associated diseases with Q6NKX5
1 regional properties for Q6NKX5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Telomeric single stranded DNA binding POT1/Cdc13 | 11 - 144 | IPR011564 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear telomere cap complex | A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| G-rich strand telomeric DNA binding | Binding to G-rich, single-stranded, telomere-associated DNA. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| single-stranded telomeric DNA binding | Binding to single-stranded telomere-associated DNA. |
| telomerase inhibitor activity | Binds to and stops, prevents or reduces the activity of telomerase. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of telomerase activity | Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| regulation of telomere maintenance via telomerase | Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase. |
| telomere capping | A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. |
| telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32797 | CDC13 | Cell division control protein 13 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEERRDDYK | FLRIQDAFKA | LHLHVNLIGV | IVELGFSNGS | DCSCTLKIVD | PWYSGSGLPV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KFVARTIRDL | PRVESIGDII | LLSRVKIVLI | NRKITALCNE | TTSSSFALFN | GKHSVDSIPY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QSSPKFLMRE | QDKNFLSNLR | EWMITYKFED | GSCCFTSLKD | IKEGECSNLS | CQIVHISKVY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KDRWYLFVWD | GTEMPPCNIL | VKSERLPLCV | EPEMLPTYML | RKFPTFGSVL | RIIVDRVSEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QAIHCLQPGQ | HVKLLNLFFQ | VNMGLWNATF | TPSTKMQYTM | SREMEAFSPQ | RMCGEKFSPR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WNPIARCISR | SHSEITGVAH | DDAPFVSLMD | ILTYHNVTAK | FRCVVRFIQV | YPRDVRKLRD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| INGNIKLVAI | LEDATARIHA | SLYADEGEKF | FGCDESDEEA | LVKKLNRLLG | GEEMEKVPRN |
| 430 | 440 | 450 | |||
| PPWVQCCLFS | FYKHKMDQWE | SRRFRIFDTW | INAS |