P32797
PR
Gene name |
CDC13 (YDL220C) |
Protein name |
Cell division control protein 13 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDL220C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
8 structures for P32797
32 variants for P32797
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-64835 | 62 | G>E | No | SGRP | |
| s04-64833 | 63 | D>N | No | SGRP | |
| s04-64608 | 138 | N>D | No | SGRP | |
| s04-64562 | 153 | S>N | No | SGRP | |
| s04-64535 | 162 | S>L | No | SGRP | |
| s04-64526 | 165 | S>N | No | SGRP | |
| s04-64511 | 170 | S>L | No | SGRP | |
| s04-64506 | 172 | E>K | No | SGRP | |
| s04-64432 | 196 | D>E | No | SGRP | |
| s04-64376 | 215 | K>R | No | SGRP | |
| s04-64217 | 268 | D>G | No | SGRP | |
| s04-64152 | 290 | T>A | No | SGRP | |
| s04-64140 | 294 | T>S | No | SGRP | |
| s04-64077 | 315 | V>I | No | SGRP | |
| s04-63993 | 343 | R>C | No | SGRP | |
| s04-63901 | 373 | Q>H | No | SGRP | |
| s04-63847 | 391 | Q>H | No | SGRP | |
| s04-63840 | 394 | P>A | No | SGRP | |
| s04-63705 | 439 | E>K | No | SGRP | |
| s04-63654 | 456 | D>N | No | SGRP | |
| s04-63546 | 492 | D>N | No | SGRP | |
| s04-63542 | 493 | P>L | No | SGRP | |
| s04-63537 | 495 | R>G | No | SGRP | |
| s04-63396 | 542 | F>L | No | SGRP | |
| s04-63386 | 545 | S>T | No | SGRP | |
| s04-63229 | 597 | N>K | No | SGRP | |
| s04-63069 | 651 | P>S | No | SGRP | |
| s04-63047 | 658 | R>T | No | SGRP | |
| s04-62952 | 690 | G>S | No | SGRP | |
| s04-62727 | 765 | I>V | No | SGRP | |
| s04-62367 | 885 | S>G | No | SGRP | |
| s04-62325 | 899 | L>V | No | SGRP |
No associated diseases with P32797
13 regional properties for P32797
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 312 - 351 | IPR001680-1 |
| repeat | WD40 repeat | 354 - 449 | IPR001680-2 |
| repeat | WD40 repeat | 469 - 507 | IPR001680-3 |
| repeat | WD40 repeat | 510 - 628 | IPR001680-4 |
| domain | F-box domain | 212 - 258 | IPR001810 |
| conserved_site | WD40 repeat, conserved site | 378 - 392 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 493 - 507 | IPR019775-2 |
| conserved_site | WD40 repeat, conserved site | 536 - 550 | IPR019775-3 |
| conserved_site | WD40 repeat, conserved site | 576 - 590 | IPR019775-4 |
| repeat | G-protein beta WD-40 repeat | 378 - 392 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 493 - 507 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 576 - 590 | IPR020472-3 |
| domain | Cell division control protein 4, dimerisation domain | 162 - 212 | IPR031740 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| CST complex | A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection. |
| nuclear telomere cap complex | A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| G-rich strand telomeric DNA binding | Binding to G-rich, single-stranded, telomere-associated DNA. |
| identical protein binding | Binding to an identical protein or proteins. |
| single-stranded telomeric DNA binding | Binding to single-stranded telomere-associated DNA. |
| telomerase inhibitor activity | Binds to and stops, prevents or reduces the activity of telomerase. |
| translation elongation factor binding | Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| negative regulation of telomerase activity | Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). |
| regulation of telomere maintenance via telomerase | Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase. |
| ribonucleoprotein complex localization | Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. |
| telomere capping | A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. |
| telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
| telomere maintenance via telomerase | The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q6NKX5 | POT1B | Protection of telomeres protein 1b | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDTLEEPECP | PHKNRIFVSS | SKDFEGYPSK | AIVPVQFVAL | LTSIHLTETK | CLLGFSNFER |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RGDQSQEDQY | LIKLKFKDRG | SERLARITIS | LLCQYFDIEL | PDLDSDSGAS | PTVILRDIHL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ERLCFSSCKA | LYVSKHGNYT | LFLEDIKPLD | LVSVISTIST | KSTNSSKHSS | SELISECDLN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSLVDIFNNL | IEMNRDEKNR | FKFVKLIHYD | IELKKFVQDQ | QKVLSQKSKA | AAINPFFVPN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLGIPYIESQ | NEFNSQLMTL | NVDEPTTDIS | NMGEEMHDSA | DPIEDSDSST | TSSTGKYFSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KSYIQSQTPE | RKTSVPNNWH | DDDSGSKRKR | KLSFHSPNAS | SIRKAISYEQ | LSLASVGSVE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RLEGKIVGMN | PPQFASINEF | KYCTLKLYFT | QLLPNVPDKV | LVPGVNCIEI | VIPTRERICE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LFGVLNCQSD | KISDILLLEK | PDRISVEVER | ILWDNDKTAS | PGMAVWSLKN | ISTDTQAQAQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VQVPAQSSAS | IDPSRTRMSK | MARKDPTIEF | CQLGLDTFET | KYITMFGMLV | SCSFDKPAFI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SFVFSDFTKN | DIVQNYLYDR | YLIDYENKLE | LNEGFKAIMY | KNQFETFDSK | LRKIFNNGLR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DLQNGRDENL | SQYGIVCKMN | IKVKMYNGKL | NAIVRECEPV | PHSQISSIAS | PSQCEHLRLF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YQRAFKRIGE | SAISRYFEEY | RRFFPIHRNG | SHLAKLRFDE | VKHEPKKSPT | TPALAEHIPD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LNADVSSFDV | KFTDISSLLD | SSARLPRPQQ | THKSNTLYSC | EGRIIAIEYH | ASDLCFHITN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ELPLLQTRGL | APERVLQLHI | ITSKNFAYFF | NRSSAYLQRQ | PLEEKYTQLA | QFLGHSFKFN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ITSSLTLFPD | TTVALQIWCP | IECTFRELQQ | QLAHPKVAAA | PDSGSLDCAI | NATVNPLRLL |
| 910 | 920 | ||||
| AAQNGVTVKK | EEDNDDDAGA | VPTS |