Q6JHU7

PR
Gene name
P3H2
Protein name
Prolyl 3-hydroxylase 2
Names
Leprecan-like protein 1
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:414143
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

313-455 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6JHU7

Entry ID Method Resolution Chain Position Source
AF-Q6JHU7-F1 Predicted AlphaFoldDB

No variants for Q6JHU7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6JHU7

No associated diseases with Q6JHU7

3 regional properties for Q6JHU7

Type Name Position InterPro Accession
domain Oxoglutarate/iron-dependent dioxygenase 543 - 657 IPR005123
domain Prolyl 4-hydroxylase, alpha subunit 448 - 656 IPR006620
domain Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain 566 - 655 IPR044862

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum
  • Sarcoplasmic reticulum
  • Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
basement membrane A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
sarcoplasmic reticulum A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.

3 GO annotations of molecular function

Name Definition
iron ion binding Binding to an iron (Fe) ion.
L-ascorbic acid binding Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
procollagen-proline 3-dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.

3 GO annotations of biological process

Name Definition
collagen metabolic process The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
peptidyl-proline hydroxylation The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IVL5 P3H2 Prolyl 3-hydroxylase 2 Homo sapiens (Human) PR
Q4KLM6 P3h2 Prolyl 3-hydroxylase 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAPGSRSWGA VLLLAAMLPA ACGSCGADGG PLEPFDALYA SGVEAYYGGD FAGAARCLEQ
70 80 90 100 110 120
ALRSRRELRA ERLRCRRRCR GQVRLAALGA GPAGELPFFG ALLRRAGCLR SCEEPRLGAA
130 140 150 160 170 180
SRHRAAEEVR SDFQRRVPYS YLQRAYIQLN KLEEAANAAH TFFMANPEHM EIQQDIENYK
190 200 210 220 230 240
TTAGKVSLID LEAKPHMEDY SAGVRHYDKE EYGLAITFLE RALEGYYAED EDCQIMCEGP
250 260 270 280 290 300
QRFEEHEYLE YKAGLYEAIA DHYMQVLACK HDCIRELATR SGRISPIENF LPLHYDYLQF
310 320 330 340 350 360
AYYRVGDYVK ALECARSYLL FHPDDEDVLE NAAYYEGLLE GTVDPATIKP RKEAKALLRR
370 380 390 400 410 420
HKLESHLLRV AAVGLGFTYT EPNYWKRYGA RQDEHSVPSS ISSEPEDGPR LSLTKKPTPK
430 440 450 460 470 480
PDRELKEGGP LLYSDVKFVY NSQQLNGTQR VLLDNVISEE QCRELHRVAS GIMLAGDGYR
490 500 510 520 530 540
GKTSPHTPNE RFEGATVLKA LKYGYEGRVP LKSARLFYDI SEKARRIVES YFMLNSTLYF
550 560 570 580 590 600
SYTHLVCRTA LSGQQERRND LSHPIHADNC LLDPEANECW KEPPAYTFRD YSALLYMNAD
610 620 630 640 650 660
FEGGEFIFTE MDAKTVTASI KPKCGRMVSF SSGGENPHGV KAVTKGQRCA VALWFTLDPL
670 680 690
YRELERIQAD EVIAMLDQEH VGRSEMNINP KDEL