AiPD: Autoinhibited Protein Database

Q6FI81

Gene name	CIAPIN1
Protein name	Anamorsin
Names	Cytokine-induced apoptosis inhibitor 1, Fe-S cluster assembly protein DRE2 homolog
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57019
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

102-224 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

102-224 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q6FI81

Entry ID	Method	Resolution	Chain	Position	Source
2LD4	NMR	-	A	1-172	PDB
2YUI	NMR	-	A	1-170	PDB
4M7R	X-ray	180 A	A/B	1-172	PDB
AF-Q6FI81-F1	Predicted				AlphaFoldDB

219 variants for Q6FI81

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	1	M>?	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8076033 rs766425632	8	A>V		No	ClinGen ExAC gnomAD
rs1414855745 CA396046556	11	F>L		No	ClinGen TOPMed gnomAD
rs750543292 CA8076031	13	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1598028442 CA396046514	14	V>G		No	ClinGen Ensembl
rs200589955 CA8076030	15	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA396046505 rs1157289338	15	V>I		No	ClinGen gnomAD
rs1179039404 CA396046495	16	W>R		No	ClinGen gnomAD
rs774159472 CA8076028	17	D>G		No	ClinGen ExAC gnomAD
CA396046443 rs1428559181	18	K>N		No	ClinGen TOPMed
rs1237441422 CA396046449	18	K>T		No	ClinGen gnomAD
CA281576518 rs1043126	19	S>L		No	ClinGen Ensembl
rs762938715 CA8076026	20	S>P		No	ClinGen ExAC gnomAD
rs1356951012 CA396046413	20	S>Y		No	ClinGen TOPMed
rs1024328742 CA281576506	21	P>A		No	ClinGen TOPMed
CA396046397 rs1289290354	21	P>L		No	ClinGen TOPMed
rs1024328742 CA396046400	21	P>S		No	ClinGen TOPMed
rs775064708 CA8076025	22	V>M		No	ClinGen ExAC TOPMed
CA8076024 rs370700464	26	K>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA8076023 rs745400937	28	L>M		No	ClinGen ExAC gnomAD
rs780659888 CA8076022	29	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1444846204 CA396046266	30	D>G		No	ClinGen TOPMed
rs181730613 CA8076021	31	K>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1353599025 CA396046241	33	Q>*		No	ClinGen TOPMed gnomAD
rs1353599025 CA396046242	33	Q>E		No	ClinGen TOPMed gnomAD
rs1472738095 CA396046238	33	Q>R		No	ClinGen TOPMed
CA8076019 rs11557672 VAR_033747	34	A>E		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8076020 rs11557672	34	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8076016 rs200697174	36	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs140903446 CA8076014	37	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA281576431 rs746806516	38	N>D		No	ClinGen Ensembl
rs762059992 CA8076012	40	G>A		No	ClinGen ExAC gnomAD
COSM971828 rs751344858 CA8076011	41	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs763946631 CA8076010	41	R>H		No	ClinGen ExAC TOPMed gnomAD
rs775237218 CA8076008	42	V>M		No	ClinGen ExAC TOPMed gnomAD
CA396046142 rs1217456701	44	V>L		No	ClinGen gnomAD
CA8076007 rs201151686	47	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1209183570 CA396046071	49	Q>*		No	ClinGen gnomAD
rs770686351 CA8076004	50	L>M		No	ClinGen ExAC gnomAD
CA8076003 rs746714326	51	L>W		No	ClinGen ExAC TOPMed gnomAD
CA8076001 rs11557674 VAR_033748	52	Q>E		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1434559902 CA396045999	52	Q>H		No	ClinGen TOPMed gnomAD
CA396045760 rs1345209531	53	S>Y		No	ClinGen TOPMed
CA396045748 rs1598027252	54	A>V		No	ClinGen Ensembl
rs1452418305 CA396045733	55	H>R		No	ClinGen TOPMed
CA396045645 rs1287702859	59	S>N		No	ClinGen TOPMed
CA396045635 rs1174413623	59	S>R		No	ClinGen TOPMed gnomAD
TCGA novel	60	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1424067607 CA396045600	61	D>A		No	ClinGen gnomAD
CA396045581 rs1199652429	62	I>V		No	ClinGen gnomAD
TCGA novel	63	I>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs183776874 CA8075984	63	I>F		No	ClinGen 1000Genomes ExAC gnomAD
CA396045544 rs1248966188	64	L>V		No	ClinGen gnomAD
CA8075983 rs772941639	65	S>L		No	ClinGen ExAC gnomAD
CA281575750 rs533025302	66	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA8075982 rs545260017	71	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8075981 rs368064049	72	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396045345 rs368064049	72	T>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396045309 rs1311355266	74	L>M		No	ClinGen gnomAD
rs1264034725 CA396045264	75	H>Q		No	ClinGen gnomAD
rs770176138 CA8075979	76	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs201547375 CA8075978	78	E>A		No	ClinGen ExAC TOPMed gnomAD
CA8075977 rs781669389	79	I>T		No	ClinGen ExAC
CA8075976 rs757273392	80	L>F		No	ClinGen ExAC gnomAD
CA8075975 rs191597700	81	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA8075974 rs758660761	84	A>S		No	ClinGen ExAC TOPMed gnomAD
rs758660761 CA8075973	84	A>T		No	ClinGen ExAC TOPMed gnomAD
rs202064597 CA8075971	85	R>Q	Variant assessed as Somatic; 0.0002319 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs752413838 CA8075972	85	R>W		No	ClinGen ExAC TOPMed gnomAD
rs754865510 CA8075970	86	I>V		No	ClinGen ExAC gnomAD
rs766432066 CA8075968	88	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8075969 rs753740875	88	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760213310 CA8075967	89	P>S		No	ClinGen ExAC gnomAD
CA396044879 rs1180847409	91	G>R		No	ClinGen gnomAD
CA8075966 rs772875822	92	C>R		No	ClinGen ExAC gnomAD
CA396044817 rs1252623826	93	L>V		No	ClinGen gnomAD
rs1598027107 COSM1728360 CA396044759	95	L>P	liver [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1482833380 CA396044707	96	K>R		No	ClinGen gnomAD
rs1205889703 CA396044632	98	P>Q		No	ClinGen gnomAD
CA396044620 rs1267687279	99	V>I		No	ClinGen gnomAD
CA8075963 rs775701720	100	E>Q		No	ClinGen ExAC gnomAD
TCGA novel	101	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8075962 rs770131811	102	A>V		No	ClinGen ExAC gnomAD
CA8075947 rs201717110	104	D>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA281574405 rs371150671	104	D>E		No	ClinGen ESP TOPMed gnomAD
TCGA novel	104	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200237174 CA8075946	105	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8075945 rs751167560	106	N>D		No	ClinGen ExAC gnomAD
CA281574380 rs889130849	106	N>S		No	ClinGen Ensembl
rs1292030804 CA396043481	107	S>G		No	ClinGen TOPMed
CA8075944 rs763677748	111	T>I		No	ClinGen ExAC gnomAD
CA8075943 rs377204698	112	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201936093 CA8075942	112	A>V		No	ClinGen ExAC gnomAD
CA8075940 rs761232060	113	S>P		No	ClinGen ExAC gnomAD
CA281574340 rs933380741	114	K>E		No	ClinGen Ensembl
rs778925110 CA8075939	116	C>R		No	ClinGen ExAC TOPMed gnomAD
CA8075938 rs772120629	116	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA396043401 rs368842581	117	S>*		No	ClinGen ESP TOPMed gnomAD
CA281574322 rs368842581	117	S>L		No	ClinGen ESP TOPMed gnomAD
rs1385819236 CA396043384	119	L>V		No	ClinGen TOPMed gnomAD
rs924745770 CA281574319	120	T>A		No	ClinGen Ensembl
rs1165360970 CA396043364	120	T>I		No	ClinGen gnomAD
CA8075937 rs748187279	122	S>A		No	ClinGen ExAC gnomAD
CA396043319 rs1194244757	124	L>H		No	ClinGen gnomAD
CA396043298 rs1208762937	126	E>*		No	ClinGen TOPMed
rs779143423 CA8075936	127	V>L		No	ClinGen ExAC gnomAD
CA8075935 rs753582284	128	K>N		No	ClinGen ExAC gnomAD
CA396043254 rs1209344563	129	E>K		No	ClinGen gnomAD
rs772476489 CA8075920	132	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs773648892 CA8075921	132	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs761909212 CA8075919	133	E>*		No	ClinGen ExAC TOPMed gnomAD
rs768900319 CA8075917	136	T>I		No	ClinGen ExAC TOPMed gnomAD
rs779988554 CA8075915	138	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA396041916 rs1329413106	140	V>L		No	ClinGen gnomAD
rs769656205 CA8075914	141	Q>L		No	ClinGen ExAC TOPMed gnomAD
rs1176057579 CA396041832	143	V>I		No	ClinGen gnomAD
CA8075912 rs781144913	144	R>G		No	ClinGen ExAC gnomAD
COSM416964 rs200237459 CA8075911	144	R>Q	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs777209696 CA8075909	145	E>K		No	ClinGen ExAC gnomAD
rs758044193 CA8075908	147	L>R		No	ClinGen ExAC gnomAD
rs1234793124 CA396041746	147	L>V		No	ClinGen TOPMed
CA396041693 rs1355075357	149	H>R		No	ClinGen TOPMed
rs367825068 CA8075906	150	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1246309963 CA396041607	151	S>N		No	ClinGen TOPMed gnomAD
CA396041599 rs1255895129	152	D>N		No	ClinGen gnomAD
CA396041511 rs1222670053	155	L>V		No	ClinGen TOPMed gnomAD
TCGA novel	158	Q>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396041412 rs1204629763	158	Q>E		No	ClinGen TOPMed gnomAD
CA396041351 rs1476376868	160	T>I		No	ClinGen TOPMed
CA8075903 rs768033422	164	P>Q		No	ClinGen ExAC gnomAD
CA8075904 rs750781006	164	P>T		No	ClinGen ExAC TOPMed gnomAD
CA8075901 rs774474867	166	F>L		No	ClinGen ExAC gnomAD
CA396041172 rs1456463525	167	E>G		No	ClinGen TOPMed
rs764144974 CA8075900	168	V>G		No	ClinGen ExAC gnomAD
CA396041150 rs1335847833	169	G>D		No	ClinGen gnomAD
rs1408604602 CA396041124	170	S>F		No	ClinGen TOPMed gnomAD
CA396041126 rs1408604602	170	S>Y		No	ClinGen TOPMed gnomAD
TCGA novel	173	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8075898 rs775808371	177	S>P		No	ClinGen ExAC TOPMed gnomAD
CA396040983 rs1383393927	178	I>V		No	ClinGen gnomAD
rs1408790486 CA396040930	180	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs745627943 CA8075896	181	K>E		No	ClinGen ExAC gnomAD
CA396040489 rs1357265598	188	P>L		No	ClinGen TOPMed
CA281572806 rs137979809	189	A>T		No	ClinGen 1000Genomes gnomAD
TCGA novel	189	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1242224163 CA396040460	190	V>M		No	ClinGen TOPMed
rs764484598 CA8075868	193	A>T		No	ClinGen ExAC gnomAD
CA396040359 rs1316100345	194	A>V		No	ClinGen TOPMed
CA396040220 rs1162254095	200	L>H		No	ClinGen TOPMed
CA396040148 rs1479202972	204	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1159758435 CA396040132	205	M>V		No	ClinGen TOPMed
rs753011617 CA8075862	208	D>N		No	ClinGen ExAC gnomAD
CA396039990 rs1249933935	209	S>G		No	ClinGen gnomAD
rs535658771 CA8075860	210	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs974082167 CA281572395	216	D>G		No	ClinGen Ensembl
rs778341332 CA396039690	217	E>D		No	ClinGen ExAC TOPMed gnomAD
CA8075840 rs747314396	217	E>Q		No	ClinGen ExAC gnomAD
rs758973105 CA8075838	222	E>A		No	ClinGen ExAC gnomAD
CA396039568 rs1174416920	222	E>D		No	ClinGen TOPMed
CA8075836 rs779579156	227	P>T		No	ClinGen ExAC gnomAD
rs1158384696 CA396039320	231	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8075834 rs140678062	233	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs562918898 CA8075835	233	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	234	A>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396039264 rs1181551737	234	A>T		No	ClinGen gnomAD
TCGA novel	234	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766476979 CA8075833	236	S>A		No	ClinGen ExAC TOPMed gnomAD
CA396039131 rs1407716280	239	E>K		No	ClinGen TOPMed
rs1205786555 CA396039063	242	K>N		No	ClinGen gnomAD
CA396039037 rs1345798948	244	K>E		No	ClinGen TOPMed
rs761001891 CA8075832	246	C>S		No	ClinGen ExAC TOPMed gnomAD
rs1280877352 CA396038982	248	N>H		No	ClinGen TOPMed
rs989685762 CA281571959	252	G>V		No	ClinGen Ensembl
CA396038895 COSM1248333 rs1181713950	255	E>K	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed
CA8075812 rs767739743	257	L>V		No	ClinGen ExAC gnomAD
CA396038823 rs1412064443	259	K>R		No	ClinGen TOPMed
rs1160025207 CA396038803	260	E>D		No	ClinGen TOPMed
CA8075810 rs751385677	263	R>G		No	ClinGen ExAC gnomAD
CA396038756 rs1164801440	263	R>K		No	ClinGen gnomAD
rs1377007057 CA396038739	264	E>A		No	ClinGen gnomAD
CA281571930 rs576642106	266	M>L		No	ClinGen 1000Genomes TOPMed
rs763917422 CA8075809	267	S>T		No	ClinGen ExAC gnomAD
CA396038663 rs1194141126	269	Q>*		No	ClinGen TOPMed gnomAD
CA396038655 rs371655964	269	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA396038665 rs1194141126	269	Q>K		No	ClinGen TOPMed gnomAD
CA281571905 rs774985672	269	Q>R		No	ClinGen Ensembl
CA8075806 rs373917007	270	P>S		No	ClinGen ESP ExAC gnomAD
rs1567569476 CA396037939	275	G>A		No	ClinGen Ensembl
rs759134563 CA396037922	276	N>K		No	ClinGen ExAC gnomAD
rs776016026 CA8075779	278	Y>C		No	ClinGen ExAC TOPMed gnomAD
COSM3818149 CA8075776 rs745916329	281	D>N	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs548083325 CA281571186	282	A>T		No	ClinGen Ensembl
CA8075775 rs781308484	283	F>V		No	ClinGen ExAC TOPMed gnomAD
CA8075774 rs771140310	284	R>C		No	ClinGen ExAC TOPMed gnomAD
rs747188516 CA8075773	284	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs771140310 CA396037687	284	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1598019889 CA396037666	285	C>Y		No	ClinGen Ensembl
rs777875310 CA8075772	287	S>G		No	ClinGen ExAC TOPMed gnomAD
rs758167973 CA8075771	287	S>R		No	ClinGen ExAC gnomAD
CA281571174 rs545433080	289	P>S		No	ClinGen 1000Genomes
rs752468818 CA8075770	290	Y>*		No	ClinGen ExAC gnomAD
CA8075769 rs778882419	291	L>F		No	ClinGen ExAC gnomAD
CA281571170 rs56343076	292	G>R		No	ClinGen Ensembl
rs184348622 CA281571168	293	M>I		No	ClinGen 1000Genomes
CA8075767 rs753383450	294	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs1240938141 CA396037492	296	F>Y		No	ClinGen gnomAD
rs1202625534 CA396037476	298	P>A		No	ClinGen gnomAD
rs1461431076 CA396037473	298	P>R		No	ClinGen gnomAD
rs192801865 CA8075765	300	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61743712 CA396037444	301	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1416564999 CA396037436	302	V>A		No	ClinGen TOPMed
CA396037412 rs1308796532	305	S>N		No	ClinGen gnomAD
CA396037399 rs1567568872	306	D>G		No	ClinGen Ensembl
TCGA novel	307	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8075761 rs575853934	307	S>T		No	ClinGen 1000Genomes ExAC TOPMed
rs760103974 CA8075758	310	H>L		No	ClinGen ExAC gnomAD
rs760103974 CA396037339	310	H>R		No	ClinGen ExAC gnomAD
rs770273808 CA8075759	310	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA396037289 rs1314704965	313	A>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD

No associated diseases with Q6FI81

3 regional properties for Q6FI81

Type	Name	Position	InterPro Accession
domain	Methyltransferase type 11	25 - 94	IPR013216
domain	Anamorsin, C-terminal	236 - 267	IPR046408-1
domain	Anamorsin, C-terminal	270 - 303	IPR046408-2

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Mitochondrion intermembrane space
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial intermembrane space	The region between the inner and outer lipid bilayers of the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

5 GO annotations of molecular function

Name	Definition
2 iron, 2 sulfur cluster binding	Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
4 iron, 4 sulfur cluster binding	Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
electron transfer activity	Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
metal ion binding	Binding to a metal ion.
methyltransferase activity	Catalysis of the transfer of a methyl group to an acceptor molecule.

5 GO annotations of biological process

Name	Definition
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
hemopoiesis	The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
iron-sulfur cluster assembly	The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
sequestering of metal ion	The process of binding or confining metal ions such that they are separated from other components of a biological system.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8WTY4	Ciapin1	Anamorsin	Mus musculus (Mouse)	PR
Q5XID1	Ciapin1	Anamorsin	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MADFGISAGQ	FVAVVWDKSS	PVEALKGLVD	KLQALTGNEG	RVSVENIKQL	LQSAHKESSF
70	80	90	100	110	120
DIILSGLVPG	STTLHSAEIL	AEIARILRPG	GCLFLKEPVE	TAVDNNSKVK	TASKLCSALT
130	140	150	160	170	180
LSGLVEVKEL	QREPLTPEEV	QSVREHLGHE	SDNLLFVQIT	GKKPNFEVGS	SRQLKLSITK
190	200	210	220	230	240
KSSPSVKPAV	DPAAAKLWTL	SANDMEDDSM	DLIDSDELLD	PEDLKKPDPA	SLRAASCGEG
250	260	270	280	290	300
KKRKACKNCT	CGLAEELEKE	KSREQMSSQP	KSACGNCYLG	DAFRCASCPY	LGMPAFKPGE
310
KVLLSDSNLH	DA