Q6DGS3
Gene name |
camk2d2 (camk2d, camk2da, zgc:92792) |
Protein name |
Calcium/calmodulin-dependent protein kinase type II delta 2 chain |
Names |
EC 2.7.11.17 , Calcium/calmodulin-dependent protein kinase type II delta-A chain , CaM kinase II subunit delta-A , CaM-kinase II delta-A chain , CaMK-II subunit delta-A |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
dre:436815 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
13-271 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
155-178 (Activation loop from InterPro)
Target domain |
13-271 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Rosenberg OS et al. (2005) "Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme", Cell, 123, 849-60
- Rellos P et al. (2010) "Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation", PLoS biology, 8, e1000426
- Akita T et al. (2018) "De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders", Annals of clinical and translational neurology, 5, 280-296
- Morlot C et al. (2007) "Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3", Acta crystallographica. Section D, Biological crystallography, 63, 961-8
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Yang E et al. (1999) "Structural examination of autoregulation of multifunctional calcium/calmodulin-dependent protein kinase II", The Journal of biological chemistry, 274, 26199-208
- Özden C et al. (2022) "CaMKII binds both substrates and activators at the active site", Cell reports, 40, 111064
Autoinhibited structure
Activated structure
1 structures for Q6DGS3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DGS3-F1 | Predicted | AlphaFoldDB |
No variants for Q6DGS3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6DGS3 | |||||
No associated diseases with Q6DGS3
5 regional properties for Q6DGS3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 444 - 719 | IPR000719 |
| domain | EGF-like calcium-binding domain | 336 - 363 | IPR001881 |
| active_site | Serine/threonine-protein kinase, active site | 566 - 578 | IPR008271 |
| domain | Wall-associated receptor kinase | 197 - 305 | IPR013695 |
| conserved_site | EGF-like calcium-binding, conserved site | 336 - 362 | IPR018097 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| organelle | Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| calmodulin-dependent protein kinase activity | Calmodulin-dependent catalysis of the reactions |
| protein serine kinase activity | Catalysis of the reactions |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
24 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHJ9 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Bos taurus (Bovine) | SS |
| Q2HJF7 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Bos taurus (Bovine) | SS |
| Q5ZKI0 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II delta chain | Gallus gallus (Chicken) | SS |
| Q24210 | CASK | Peripheral plasma membrane protein CASK | Drosophila melanogaster (Fruit fly) | SS |
| Q00168 | CaMKII | Calcium/calmodulin-dependent protein kinase type II alpha chain | Drosophila melanogaster (Fruit fly) | SS |
| Q13555 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Homo sapiens (Human) | EV |
| O14936 | CASK | Peripheral plasma membrane protein CASK | Homo sapiens (Human) | EV |
| Q13554 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (Human) | EV |
| Q9UQM7 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (Human) | EV |
| Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (Human) | EV |
| O70589 | Cask | Peripheral plasma membrane protein CASK | Mus musculus (Mouse) | SS |
| Q923T9 | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Mus musculus (Mouse) | SS |
| P11798 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Mus musculus (Mouse) | PR |
| P28652 | Camk2b | Calcium/calmodulin-dependent protein kinase type II subunit beta | Mus musculus (Mouse) | SS |
| Q6PHZ2 | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta | Mus musculus (Mouse) | SS |
| Q95266 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Sus scrofa (Pig) | SS |
| P11275 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Rattus norvegicus (Rat) | PR |
| P11730 | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Rattus norvegicus (Rat) | SS |
| P15791 | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta | Rattus norvegicus (Rat) | SS |
| P54936 | lin-2 | Protein lin-2 | Caenorhabditis elegans | SS |
| O62305 | unc-43 | Calcium/calmodulin-dependent protein kinase type II | Caenorhabditis elegans | EV |
| Q6DEH3 | camk2d1 | Calcium/calmodulin-dependent protein kinase type II delta 1 chain | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A8C984 | mylk3 | Myosin light chain kinase 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SY49 | camkv | CaM kinase-like vesicle-associated protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYKNTNNSH | LILFKLLLLL | ILYSADLTAS | SSCRSECGGC | KCGGIAIPYP | FGIGKGCYLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KSYEIECLNT | SGKLVPFLSV | ISKEVVSIHL | PGRQSFGSVR | VRSPITSAGC | SSDGKDSAPV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MNLTDSPFFV | SDINNLVGVG | CSSKVSLEHI | KQNMVGCELN | CSTTNASDSN | SIPFFDKTGC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SFSYTFAQVC | TGNKPEDMGC | DGRGCCQASL | PREPQQVIGI | RIESNDGKST | TSGDCRVAFL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TDEFFSLSKL | TKPEQLHAKR | YATLSLGWIM | QTRNTSFVNS | LACKIRKDTD | TAYSNDQSIK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| CICDYTMSII | SDIRYANCEC | NLGYKGNPYD | SDGCRDIDEC | KENPKYCKET | DTCVNFEGGY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RCVGDKTKAI | MIGAGTGFGV | LVLVGGVWWL | RKFLVKRRMA | KRKKKFFKRN | GGLLLQQELN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TRQGVVEKAR | IFTSKELEKA | TENFSENRVL | GHGGQGTVYK | GMLVDGRTVA | VKKSKVIDED |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KLQEFINEVV | ILSQINHRHV | VKLLGCCLET | EVPILVYEFI | INGNLFKHIH | EEEADDYTMI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WGMRLRIAVD | IAGALSYLHS | AASSPIYHRD | IKSTNILLDE | KYRAKVADFG | TSRSVTIDQT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HWTTVISGTV | GYVDPEYYRS | SQYTEKSDVY | SFGVILAELI | TGDKPVIMVQ | NTQEIIALAE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HFRVAMKERR | LSDIMDARIR | DDSKPEQVMA | VANLAMKCLS | SRGRNRPNMR | EVFTELERIC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TSPEDSQVQN | RIDEEEEEDG | VEEEEEVVTI | VHRGDSWSIG | VTAPASSIVA | SPPSSDVEPL |
| NPLLTW |