AiPD: Autoinhibited Protein Database

Gene name	Ncoa7
Protein name	Nuclear receptor coactivator 7
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:211329
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-244 (Predicted disordered autoinhibitory region) PR

1-244 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6DFV7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389094431	22	K>N	No	EVA
rs33753991	38	S>A	No	EVA
rs33753989	49	N>K	No	EVA
rs215013648	59	N>H	No	EVA
rs3389086436	60	V>SDG*	No	EVA
rs3389104691	61	T>R	No	EVA
rs3389094394	69	D>H	No	EVA
rs3401071502	78	Q>L	No	EVA
rs3389094923	79	L>*	No	EVA
rs3389086428	100	T>S	No	EVA
rs3389094875	104	K>*	No	EVA
rs3389073632	104	K>I	No	EVA
rs1135251567	107	K>Q	No	EVA
rs253370919	109	M>V	No	EVA
rs1134208188	111	Q>H	No	EVA
rs1131780894	113	P>S	No	EVA
rs1135382103	115	G>S	No	EVA
rs3389095763	126	T>S	No	EVA
rs229698047	136	V>I	No	EVA
rs3401019210	177	P>R	No	EVA
rs3401020591	177	P>T	No	EVA
rs3389081686	197	D>N	No	EVA
rs3389037167	233	T>S	No	EVA
rs3389099488	327	K>N	No	EVA
rs3389103822	337	Q>K	No	EVA
rs33756807	348	A>V	No	EVA
rs33756806	352	R>G	No	EVA
rs242687872	359	E>K	No	EVA
rs33755993	360	R>H	No	EVA
rs257265368	366	E>Q	No	EVA
rs265146455	367	P>T	No	EVA
rs246572107	395	L>P	No	EVA
rs224477153	398	R>H	No	EVA
rs33755991	416	D>E	No	EVA
rs250308014	449	G>R	No	EVA
rs218829028	449	G>V	No	EVA
rs232821190	451	H>L	No	EVA
rs249561582	451	H>N	No	EVA
rs219422332	463	S>P	No	EVA
rs33755989	485	A>G	No	EVA
rs3400452123	485	A>S	No	EVA
rs3400452009	486	E>Q	No	EVA
rs33755985	497	H>Q	No	EVA
rs3399917909	516	D>G	No	EVA
rs33755103	549	I>L	No	EVA
rs33755101	572	D>G	No	EVA
rs262511183	588	P>S	No	EVA
rs3389099516	600	I>V	No	EVA
rs3389094414	724	V>SDG*	No	EVA
rs3389069002	727	E>G	No	EVA
rs3399916799	739	S>G	No	EVA
rs3389095756	744	K>M	No	EVA
rs3389095756	744	K>T	No	EVA
rs3389068997	762	S>C	No	EVA
rs216331807	779	P>T	No	EVA
rs3389095722	842	Q>*	No	EVA
rs3389086432	849	T>I	No	EVA
rs3389097191	852	F>S	No	EVA
rs3389097135	865	F>S	No	EVA
rs3389103795	897	G>E*	No	EVA

Type	Name	Position	InterPro Accession
domain	TLDc domain	781 - 943	IPR006571
domain	LysM domain	117 - 161	IPR018392

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
nuclear receptor binding	Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand.
nuclear receptor coactivator activity	A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.

Name	Definition
negative regulation of cellular response to oxidative stress	Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to oxidative stress.
negative regulation of oxidative stress-induced neuron death	Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron death.
negative regulation of peptidyl-cysteine S-nitrosylation	Any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.
positive regulation of transcription by RNA polymerase II	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to oxidative stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8NI08	NCOA7	Nuclear receptor coactivator 7	Homo sapiens (Human)	PR
Q4V8B0	Oxr1	Oxidation resistance protein 1	Rattus norvegicus (Rat)	PR