Q6DBY0
Gene name |
nup85 (pcnt1, zgc:100943) |
Protein name |
Nuclear pore complex protein Nup85 |
Names |
85 kDa nucleoporin, Nucleoporin Nup85, Pericentrin-1 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:445231 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6DBY0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6DBY0-F1 | Predicted | AlphaFoldDB |
No variants for Q6DBY0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6DBY0 | |||||
No associated diseases with Q6DBY0
No regional properties for Q6DBY0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q6DBY0 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nuclear pore outer ring | A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates). |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| structural constituent of nuclear pore | The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| nephron development | The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| protein import into nucleus | The directed movement of a protein from the cytoplasm to the nucleus. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P46673 | NUP85 | Nucleoporin NUP85 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| D7STK2 | GATC | Glutamyl-tRNA(Gln) amidotransferase subunit C, chloroplastic/mitochondrial | Vitis vinifera (Grape) | PR |
| Q9BW27 | NUP85 | Nuclear pore complex protein Nup85 | Homo sapiens (Human) | PR |
| C5WR30 | GATC | Glutamyl-tRNA(Gln) amidotransferase subunit C, chloroplastic/mitochondrial | Sorghum bicolor (Sorghum) (Sorghum vulgare) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEELDVEPST | TLVPAAGVLQ | KHLGFEWGPG | DLLVYETNYK | LRGSSSAGSP | LVHVVRKDED |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ICSPILRKLF | NESHLIFMGL | QKIKEDAPSK | NKKTQFVSIS | RNYRSVIRAC | MEELQQNAVT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AQDGSLASQY | GDQVSILLAI | ELIWNLCEVL | FIEAAPAGSL | LLHLLNWVRL | HKSDVDTRAR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVLQSENPTQ | HPAYWDVVTS | LVLQGRMDEA | RQILSKQASL | RMESSSVFKR | MDTLLQTMPI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FNPAGAQTLT | EFDVKWRHWH | EECDRCLQDH | TFASSAELET | LCKILLGDED | VILEQKDLMS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TWYHFLVSRL | LFTHPTIKPP | DLHYYAQSSM | NMFLGPRATP | EPLDIILLSA | FEFDLHQVIK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DCSIALNNWW | FVAHLTDLLD | HCKLLQSHNL | HFGSNLREFL | VLEYASGLFT | HHSLWQLAVD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YLDHCPEFGR | VYLELQIERV | PLDTERKANK | VLRICEDRQM | SEQVRSICKI | MAKRALRNNR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LGSALSWSIR | AKDAALATLI | SERFLQDYSN | KGSFTDLDVL | DNLGPAMLLS | DRLTFLGKYR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EFHRLYGENR | FSDAAKLLLS | LMMAKIAPRS | LWMTLLTDAL | PLLEQEEVIF | TVDQTYELMS |
| 610 | 620 | 630 | 640 | ||
| CLEELNSGTK | DSNQMEQEED | LESTKTELLR | VALARNLATA | IVKEGTIET |