P46673

PR
Gene name
NUP85 (RAT9, YJR042W, J1624)
Protein name
Nucleoporin NUP85
Names
Nuclear pore protein NUP85
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJR042W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

675-744 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

11 structures for P46673

Entry ID Method Resolution Chain Position Source
3EWE X-ray 350 A B/D 1-564 PDB
3F3F X-ray 290 A C/D/G/H 1-570 PDB
3F3G X-ray 375 A C/D/G/H 1-570 PDB
3F3P X-ray 320 A C/D/G/H/K/L 1-570 PDB
4XMM X-ray 738 A D 44-744 PDB
4XMN X-ray 760 A D 73-743 PDB
6X08 X-ray 419 A B 1-564 PDB
7N84 EM 1160 A b/m 1-744 PDB
7N9F EM 3700 A b/i 1-744 PDB
8TIE EM 810 A b/m 1-744 PDB
AF-P46673-F1 Predicted AlphaFoldDB

16 variants for P46673

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-514229 61 N>S No SGRP
s10-514235 63 D>G No SGRP
s10-514238 64 K>R No SGRP
s10-514256 70 K>R No SGRP
s10-514313 89 K>R No SGRP
s10-514369 108 V>I No SGRP
s10-514415 123 V>A No SGRP
s10-514552 169 V>M No SGRP
s10-514724 226 Q>R No SGRP
s10-514776 243 Q>H No SGRP
s10-514844 266 E>G No SGRP
s10-515344 433 I>V No SGRP
s10-516092 682 L>P No SGRP
s10-516203 719 S>T No SGRP
s10-516239 731 L>S No SGRP
s10-516238 731 L>V No SGRP

No associated diseases with P46673

4 regional properties for P46673

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 223 - 400 IPR002314
domain Aminoacyl-tRNA synthetase, class II 172 - 410 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 1 - 108 IPR015866
domain Serine-tRNA ligase catalytic core domain 120 - 417 IPR033729

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nuclear pore complex
  • Nucleus membrane; Peripheral membrane protein; Cytoplasmic side
  • Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side
  • Symmetric distribution
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nuclear pore outer ring A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).

1 GO annotations of molecular function

Name Definition
structural constituent of nuclear pore The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.

6 GO annotations of biological process

Name Definition
mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm.
nuclear pore localization Any process in which nuclear pores are transported to, or maintained in, a specific location.
nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
ribosomal large subunit export from nucleus The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BW27 NUP85 Nuclear pore complex protein Nup85 Homo sapiens (Human) PR
Q6DBY0 nup85 Nuclear pore complex protein Nup85 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTIDDSNRLL MDVDQFDFLD DGTAQLSNNK TDEEEQLYKR DPVSGAILVP MTVNDQPIEK
70 80 90 100 110 120
NGDKMPLKFK LGPLSYQNMA FITAKDKYKL YPVRIPRLDT SKEFSAYVSG LFEIYRDLGD
130 140 150 160 170 180
DRVFNVPTIG VVNSNFAKEH NATVNLAMEA ILNELEVFIG RVKDQDGRVN RFYELEESLT
190 200 210 220 230 240
VLNCLRTMYF ILDGQDVEEN RSEFIESLLN WINRSDGEPD EEYIEQVFSV KDSTAGKKVF
250 260 270 280 290 300
ETQYFWKLLN QLVLRGLLSQ AIGCIERSDL LPYLSDTCAV SFDAVSDSIE LLKQYPKDSS
310 320 330 340 350 360
STFREWKNLV LKLSQAFGSS ATDISGELRD YIEDFLLVIG GNQRKILQYS RTWYESFCGF
370 380 390 400 410 420
LLYYIPSLEL SAEYLQMSLE ANVVDITNDW EQPCVDIISG KIHSILPVME SLDSCTAAFT
430 440 450 460 470 480
AMICEAKGLI ENIFEGEKNS DDYSNEDNEM LEDLFSYRNG MASYMLNSFA FELCSLGDKE
490 500 510 520 530 540
LWPVAIGLIA LSATGTRSAK KMVIAELLPH YPFVTNDDIE WMLSICVEWR LPEIAKEIYT
550 560 570 580 590 600
TLGNQMLSAH NIIESIANFS RAGKYELVKS YSWLLFEASC MEGQKLDDPV LNAIVSKNSP
610 620 630 640 650 660
AEDDVIIPQD ILDCVVTNSM RQTLAPYAVL SQFYELRDRE DWGQALRLLL LLIEFPYLPK
670 680 690 700 710 720
HYLVLLVAKF LYPIFLLDDK KLMDEDSVAT VIEVIETKWD DADEKSSNLY ETIIEADKSL
730 740
PSSMATLLKN LRKKLNFKLC QAFM