Q6AY88

PR
Gene name
Kdf1
Protein name
Keratinocyte differentiation factor 1
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:313018
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

279-353 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6AY88

Entry ID Method Resolution Chain Position Source
AF-Q6AY88-F1 Predicted AlphaFoldDB

No variants for Q6AY88

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6AY88

No associated diseases with Q6AY88

No regional properties for Q6AY88

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q6AY88

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell junction
  • Localized at cell borders in single layered keratinocytes
  • Localized at cell borders in the basal and spinous layers but is more diffusely localized in the granular layer
  • Colocalized with actin near the cell membrane, especially in cellular protrusions (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
cell leading edge The area of a motile cell closest to the direction of movement.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

11 GO annotations of biological process

Name Definition
developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
establishment of skin barrier Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.
keratinocyte development The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure.
keratinocyte proliferation The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.
limb epidermis development The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium.
morphogenesis of embryonic epithelium The process in which the anatomical structures of embryonic epithelia are generated and organized.
negative regulation of keratinocyte proliferation Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.
negative regulation of stem cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.
positive regulation of epidermal cell differentiation Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.
regulation of epidermal cell division Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis.
stem cell proliferation The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NAX2 KDF1 Keratinocyte differentiation factor 1 Homo sapiens (Human) PR
A2A9F4 Kdf1 Keratinocyte differentiation factor 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MPRPGQPRPS SGPPRLGPWE RPTELCLETN DERSQPPPGR RTRRPDPKDP GHHGPESITF
70 80 90 100 110 120
ISGSAEPANE PPTCCLLWRP WGWDWCRAAF CFRRCRDCLQ RCGACVRSCS PCLSAGDPIE
130 140 150 160 170 180
GSSEAAWAKE HNGVPPSPDR APPSRRDGQK LKTSMGSSFS YPDVKLKGIP VYPYRHATSP
190 200 210 220 230 240
VPDADSCCKE PLADPPPTRH SLPSTFTSSP RGSEEYYSFH ESDLDLPEMG SGSMSSREID
250 260 270 280 290 300
VLIFKKLTEL FSVHQIDELA KCTSDTVFLE KTSKISDLIS SITQDYHLDE QDAEGRLVRG
310 320 330 340 350 360
IIRISTRKSR SRPQTSEGRS ARSTAPAAAP DSGHETMVGS GLSQDELTVQ ISQETTADAI
370 380 390
ARKLRPYGAP GYPASQDSSF QGTDTDSSGA PLLQVYC